Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2476 produtos de "Cromatina/Epigenética"
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BI01826025
BI01826025 (pArg-JQ1), a BRDT BD1 bromodomain PROTAC degrader, tests ClpC2's effect on ClpC1P1P2 protease.Fórmula:C31H42ClN10O7PSCor e Forma:SolidPeso molecular:765.22HDAC1/2-IN-3
CAS:HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.Fórmula:C24H25N5OSCor e Forma:SolidPeso molecular:431.56(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Cor e Forma:SolidKDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Cor e Forma:Odour SolidAUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Fórmula:C41H50BrN9O5Pureza:98.84%Cor e Forma:SolidPeso molecular:828.8PROTAC BRD9-binding moiety 5
CAS:PROTAC BRD9 binder moiety 5 selectively binds BRD9 with IC50 4.20μM, used in PROTAC synthesis, shows cancer cell antiproliferative activity.Fórmula:C19H18N6OCor e Forma:SolidPeso molecular:346.39PROTAC BRD4 Degrader-32
<p>PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.</p>Fórmula:C42H42ClN5O5Cor e Forma:SolidPeso molecular:731.28745DW71177
CAS:DW71177 is a BET inhibitor with potent anti-leukemic activity for the study of leukemia.Fórmula:C20H28N6O2Pureza:98.13%Cor e Forma:SoildPeso molecular:384.48EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Fórmula:C22H31FN4O3SCor e Forma:SolidPeso molecular:450.57PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Fórmula:C20H7Br6NO5Cor e Forma:SolidPeso molecular:820.702EP300/CBP ligand 2
<p>EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.</p>Fórmula:C20H18N6OCor e Forma:SolidPeso molecular:358.4AS2553627
CAS:AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38ACBI2
CAS:ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Fórmula:C56H68BrFN8O5SCor e Forma:SolidPeso molecular:1064.16PRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Fórmula:C22H16F5N5O2Cor e Forma:SolidPeso molecular:477.39MAT2A-IN-14
MAT2A-IN-14 (compound H3) is a MAT2A inhibitor that generates reactive oxygen species (ROS) following ultrasound treatment, leading to the specific degradation of MAT2A in cells through rapid oxidation reactions. When combined with ultrasound, MAT2A-IN-14 induces an 87% reduction of MAT2A in human colon cancer cells.Fórmula:C27H24F2N4O4Peso molecular:506.17656GSK232
CAS:GSK232 is a highly selective and cellularly penetrant inhibitor of CECR2 with outstanding physicochemical properties.Fórmula:C21H27ClN6O3SCor e Forma:SolidPeso molecular:479.0R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Fórmula:C111H211N59O26SPureza:98%Cor e Forma:SolidPeso molecular:2820.33Kiss2 peptide acetate
Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Fórmula:C63H84N16O12·xC2H4O2Cor e Forma:SolidPeso molecular:1257.44 (free base)AMPK activator 15
AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.Fórmula:C53H51BrNO10PSCor e Forma:SolidPeso molecular:1004.92Protein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Fórmula:C67H118N26O16Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:1543.82
