Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2540 produtos de "Cromatina/Epigenética"
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QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Fórmula:C61H72N10O10S2Cor e Forma:SolidPeso molecular:1169.42PRMT5-IN-15
CAS:PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.Fórmula:C24H23F3N6O2Cor e Forma:SolidPeso molecular:484.483HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.
Fórmula:C19H18IN3O2Peso molecular:447.04437KDM5-C49 hydrochloride
KDM5-C49 hydrochloride selectively inhibits KDM5A/B/C demethylases (IC50: 40/160/100 nM) for cancer research.Fórmula:C15H25ClN4O3Cor e Forma:SolidPeso molecular:344.84MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Cor e Forma:Odour Solid5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE
CAS:Fórmula:C12H9N3OCor e Forma:SolidPeso molecular:211.21DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Cor e Forma:Odour Solid(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Fórmula:C41H46N6O6SCor e Forma:SolidPeso molecular:750.91HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Fórmula:C41H41F4N7O11Cor e Forma:SolidPeso molecular:883.8Go6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Fórmula:C24H18N4OPureza:95.89%Cor e Forma:Off-White To Yellow SolidPeso molecular:378.43TCIP3
CAS:TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.Fórmula:C58H71ClF2N16O7Cor e Forma:SolidPeso molecular:1177.74CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Fórmula:C39H61N5O7Cor e Forma:SolidPeso molecular:711.4571HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.
Pureza:98%Cor e Forma:Odour SolidPROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Fórmula:C23H21N3O2Pureza:98%Cor e Forma:SolidPeso molecular:371.43BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67Antitumor agent-170
Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.Fórmula:C59H69ClF3N11O9Peso molecular:1167.49204UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Cor e Forma:Odour SolidPROTAC BRM degrader-1
CAS:PROTAC BRM degrader-1 (compound 17) serves as a PROTAC-based degrader targeting both BRM and BRG1, exhibiting DC50 values of 93 pM and 4.9 nM, respectively [1].Fórmula:C57H69N11O8SCor e Forma:SolidPeso molecular:1068.29PARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Fórmula:C33H31N7O3Peso molecular:573.24884Kiss2 peptide
CAS:Kiss2 peptide functions as a positive regulator of reproductive behavior. In COS-7 cells, it binds to its homologous G-protein coupled receptor Kiss2R (GPR54), activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Fórmula:C63H84N16O12Peso molecular:1257.44
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