DNA-PK
A DNA-PK (quinase dependente de DNA) é uma enzima chave envolvida na reparação de quebras de fita dupla de DNA através da via de junção de extremidades não homólogas (NHEJ). Inibidores de DNA-PK bloqueiam a atividade desta quinase, impedindo a reparação de quebras de DNA e levando ao aumento da morte celular, particularmente em células cancerígenas. Os inibidores de DNA-PK são ferramentas valiosas na pesquisa e terapia do câncer, especialmente em combinação com outros tratamentos que danificam o DNA. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de DNA-PK de alta qualidade para apoiar sua pesquisa em reparo de DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 50 produtos para "DNA-PK".
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STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Fórmula:C22H20FN5O4Pureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:437.42Ref: TM-T13017
1mg70,00€5mg150,00€1mL*10mM (DMSO)170,00€10mg219,00€25mg369,00€50mg550,00€100mg722,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Cor e Forma:White SolidPeso molecular:414.48Ref: TM-T15789
5mg43,00€1mL*10mM (DMSO)47,00€10mg71,00€25mg138,00€50mg231,00€100mg344,00€200mg505,00€(R)-VX-984
CAS:(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.Fórmula:C23H21D2N7OPureza:98%Cor e Forma:SolidPeso molecular:415.49DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Cor e Forma:Odour SolidMulti-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.Cor e Forma:Odour SolidIC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Fórmula:C12H15NO3Pureza:99.68%Cor e Forma:SolidPeso molecular:221.25AMA-37
CAS:AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.Fórmula:C17H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:283.32AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultar1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFórmula:C17H15NO3Pureza:99.51% - >99.99%Cor e Forma:SolidPeso molecular:281.31PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Cor e Forma:SolidPeso molecular:599.66Compound 401
CAS:Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.Fórmula:C16H15N3O2Pureza:99.55% - 99.73%Cor e Forma:White SolidPeso molecular:281.31LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Fórmula:C19H17NO3Pureza:98% - 99.96%Cor e Forma:White SolidPeso molecular:307.34PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Cor e Forma:SolidPeso molecular:351.36CC-115 hydrochloride
CAS:CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.Fórmula:C16H17ClN8OCor e Forma:SolidPeso molecular:372.82PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.30%Cor e Forma:Yellow SolidPeso molecular:348.36PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82% - 98%Cor e Forma:SolidPeso molecular:488.74DMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Fórmula:C9H9NO5Pureza:97.87%Cor e Forma:Yellow SolidPeso molecular:211.17KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Fórmula:C25H19NO3SPureza:98% - >99.99%Cor e Forma:White SolidPeso molecular:413.49PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Cor e Forma:SolidPeso molecular:506.64Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.46
