DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 450 produtos de "DNA Metiltransferase"
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1-Hydrazinophthalazine Hydrochloride
CAS:Fórmula:C8H8N4·HClPureza:>99.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:196.64N-Phthalyl-L-tryptophan
CAS:Fórmula:C19H14N2O4Pureza:>98.0%(T)(HPLC)Cor e Forma:Light yellow to Amber to Dark green powder to crystalinePeso molecular:334.33Genistein
CAS:Fórmula:C15H10O5Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:270.24Zebularine
CAS:Fórmula:C9H12N2O5Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:228.20(-)-Epigallocatechin Gallate Hydrate
CAS:Fórmula:C22H18O11·xH2OPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:458.38 (as Anhydrous)Procaine Hydrochloride
CAS:Fórmula:C13H20N2O2·HClPureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:272.775-Azacytidine
CAS:Fórmula:C8H12N4O5Pureza:>98.0%(T)Cor e Forma:White to Almost white powder to crystalPeso molecular:244.21Chlorogenic Acid
CAS:Fórmula:C16H18O9Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:354.31Caffeic Acid
CAS:Fórmula:C9H8O4Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Orange to Green powder to crystalPeso molecular:180.162(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS:Fórmula:C9H12N2O5Pureza:98%Cor e Forma:SolidPeso molecular:228.2020Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Fórmula:C22H28ClN3O4Pureza:99.91%Cor e Forma:SolidPeso molecular:433.934-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O5Pureza:98%Cor e Forma:SolidPeso molecular:244.2047Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFórmula:C28H36ClN3O5SPureza:98.04% - 99.872%Cor e Forma:SolidPeso molecular:562.12(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Fórmula:C16H18O9Pureza:98%Cor e Forma:SolidPeso molecular:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgA consultar25g153,00€100g489,00€250gA consultar500gA consultar50kg41.345,00€250mg26,00€Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Fórmula:C9H16N4O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:292.25MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Fórmula:C20H17FN6OPureza:98.25% - 99.92%Cor e Forma:SolidPeso molecular:376.395-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Fórmula:C8H12N4O5Pureza:98% - 99.79%Cor e Forma:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.24-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O4Pureza:98%Cor e Forma:SolidPeso molecular:228.2053Ref: IN-DA002NLT
1g99,00€5g255,00€10g563,00€25gA consultar50gA consultar5mg30,00€100gA consultar100mg31,00€250mg53,00€DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Fórmula:C25H25N3OPureza:98.95%Cor e Forma:SolidPeso molecular:383.49iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Cor e Forma:SoildPeso molecular:429.96Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Cor e Forma:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Fórmula:C26H35FN4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:486.654H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:Fórmula:C15H10O5Pureza:97%Cor e Forma:SolidPeso molecular:270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgA consultar100g114,00€10kgA consultar250g181,00€500g320,00€100mg26,00€Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFórmula:C8H14N2O2Pureza:99.67% - 99.86%Cor e Forma:White Crystalline PowderPeso molecular:170.21BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Fórmula:C14H11NO3Pureza:98.87%Cor e Forma:SolidPeso molecular:241.24(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS:Fórmula:C22H18O11Pureza:98%Cor e Forma:SolidPeso molecular:458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgA consultar100g114,00€250g177,00€500g302,00€Amodiaquine dihydrochloride dihydrate
CAS:<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Fórmula:C20H28Cl3N3O3Pureza:99.97%Cor e Forma:SolidPeso molecular:464.82Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Fórmula:C26H34ClN3O4Pureza:98.38% - 99.83%Cor e Forma:SolidPeso molecular:488.02EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Fórmula:C34H48N4O4Pureza:99.74%Cor e Forma:SolidPeso molecular:576.77Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Fórmula:C8H9ClN4Pureza:98%Cor e Forma:SolidPeso molecular:196.6369UNC-4219 TFA
CAS:UNC4219 is a control for UNC3866, blocking Kme reader function in CBX & CDY chromodomains.Fórmula:C46H69F3N6O10Pureza:98%Cor e Forma:SolidPeso molecular:923.085SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Fórmula:C44H64N6O9Pureza:98%Cor e Forma:SoildPeso molecular:821.01GSK 591 dihydrochloride
CAS:Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Fórmula:C22H30Cl2N4O2Cor e Forma:SolidPeso molecular:453.41CS-VIP 8 TFA
CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.Fórmula:C45H53F7N12O9Cor e Forma:SolidPeso molecular:1038.39467PARP/EZH2-IN-1
CAS:PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Fórmula:C43H41FN8O5Cor e Forma:SolidPeso molecular:768.85CPI-1328
CAS:CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Fórmula:C28H36ClN3O4SCor e Forma:SolidPeso molecular:546.12DDO-2093
CAS:DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Fórmula:C29H37ClFN9O3Cor e Forma:SolidPeso molecular:614.12C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Fórmula:C90H161ClN36O24Pureza:98%Cor e Forma:SolidPeso molecular:2166.94Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Cor e Forma:Odour SolidMS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>PRMT5-IN-14
CAS:PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.Fórmula:C18H18Cl2N4O4Cor e Forma:SolidPeso molecular:425.27LSD1-IN-32
<p>LSD1-IN-32 (compound 11e) is a potent inhibitor of LSD1, with an IC50 value of 0.99 µM. It effectively impedes RANKL-induced osteoclastogenesis, bone resorption, and F-actin ring formation, indicating its potential use in osteoporosis research.</p>Fórmula:C36H56N2O3Si2Peso molecular:620.38295UNC 0631
CAS:UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).Fórmula:C37H61N7O2Pureza:97.42%Cor e Forma:SolidPeso molecular:635.93WDR5-47
CAS:WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Fórmula:C19H20ClFN4O3Pureza:98.15%Cor e Forma:SoildPeso molecular:406.84Histone H3K9me3 (1-15) TFA
Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.Fórmula:C66H124N25O21·xC2HF3O2Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Cor e Forma:Odour SolidPARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Fórmula:C33H31N7O3Peso molecular:573.24884BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Fórmula:C37H47N5O5SCor e Forma:SolidPeso molecular:673.32979PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Cor e Forma:Odour SolidBAY-6035
CAS:BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.Fórmula:C22H28N4O3Pureza:99.97%Cor e Forma:SolidPeso molecular:396.48MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Fórmula:C64H84F3N11O7SCor e Forma:SolidPeso molecular:1208.5XF056-132
CAS:XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Fórmula:C51H57F4N9O7SCor e Forma:SolidPeso molecular:1016.11Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Fórmula:C34H43N3O7Cor e Forma:SolidPeso molecular:605.72SW2_110A
CAS:<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Fórmula:C42H60N6O7Pureza:98%Cor e Forma:SolidPeso molecular:760.96METTL16-IN-1
METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity.Fórmula:C19H12BrN3O6S2Peso molecular:520.93509PRMT5-IN-13
CAS:PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .Fórmula:C18H17ClN4O4Cor e Forma:SolidPeso molecular:388.81MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Cor e Forma:SolidPeso molecular:718.93Dot1L-IN-8
Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.Fórmula:C41H53N7O3SCor e Forma:SolidPeso molecular:723.97PRMT5-IN-15
CAS:PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.Fórmula:C24H23F3N6O2Cor e Forma:SolidPeso molecular:484.483MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Fórmula:C28H42ClN5O3Pureza:98.9% - 98.96%Cor e Forma:SolidPeso molecular:532.12EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Fórmula:C25H40Cl2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:515.51PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Fórmula:C30H25F2N7O2Cor e Forma:SolidPeso molecular:553.56PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Fórmula:C11H13N3O4SCor e Forma:SolidPeso molecular:283.3MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Cor e Forma:SolidDC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Fórmula:C15H15N3O5SPureza:99.37%Cor e Forma:SolidPeso molecular:349.36PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Fórmula:C20H26N6O2Cor e Forma:SolidPeso molecular:382.459EZH2-IN-5
CAS:<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Cor e Forma:Odour SolidEZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Fórmula:C32H44N4O4Pureza:99.88%Cor e Forma:SolidPeso molecular:548.72Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Cor e Forma:Odour SolidAnticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYCFórmula:C25H11BBr2F2N2O3S4Pureza:98%Cor e Forma:SolidPeso molecular:724.23Dihydro-5-azacytidine
CAS:Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Fórmula:C8H14N4O5Pureza:>99.99%Cor e Forma:SolidPeso molecular:246.22DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Cor e Forma:Odour SolidCARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associatedFórmula:C72H100N12O7SPureza:98%Cor e Forma:SolidPeso molecular:1277.71Nanaomycin A
CAS:Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).Fórmula:C16H14O6Pureza:98%Cor e Forma:SolidPeso molecular:302.28IHMT-EZH2-426
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5Fórmula:C31H35FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:578.7CS-VIP 8
CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.Fórmula:C43H52F4N12O7Cor e Forma:SolidPeso molecular:924.4018PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Fórmula:C23H29N7OPureza:98%Cor e Forma:SolidPeso molecular:419.52EZH2-IN-4
CAS:EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.Fórmula:C29H41N3O3SCor e Forma:SolidPeso molecular:511.73SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Fórmula:C45H62Cl3N7O8Cor e Forma:SolidPeso molecular:935.37EEDi-5273
CAS:EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Fórmula:C26H22F4N6O2Cor e Forma:SolidPeso molecular:526.496CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Fórmula:C27H35ClN6O3Cor e Forma:SolidPeso molecular:527.06MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Fórmula:C58H66ClF3N14O11S2Cor e Forma:SolidPeso molecular:1290.41175PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryPureza:98%Cor e Forma:Odour SolidML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Cor e Forma:Odour SolidPRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Fórmula:C22H16F5N5O2Peso molecular:477.39G9a-IN-3
G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.Fórmula:C26H29N5O3Cor e Forma:SolidPeso molecular:459.22704EML734
CAS:EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.Fórmula:C27H32N10O7Pureza:98%Cor e Forma:SolidPeso molecular:608.61FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Cor e Forma:Odour SolidA-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Fórmula:C29H38Cl2N4O4Cor e Forma:SolidPeso molecular:577.54UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Fórmula:C50H58FN11O6SPureza:98%Cor e Forma:SolidPeso molecular:960.13MS9715
MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligaseFórmula:C58H74FN9O5SPureza:98%Cor e Forma:SolidPeso molecular:1028.33ND-L11B free base
ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.Fórmula:C37H51F3N10O2Cor e Forma:SolidPeso molecular:724.862PRMT5-IN-34
<p>PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).</p>Fórmula:C23H19F2N5O2Peso molecular:435.15068PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Fórmula:C32H40N4O4Cor e Forma:SolidPeso molecular:544.696EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Fórmula:C22H31FN4O3SCor e Forma:SolidPeso molecular:450.57NSD2-IN-4
<p>NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].</p>Fórmula:C18H14ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.78Chaetocin
CAS:<p>Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.</p>Fórmula:C30H28N6O6S4Pureza:98.36% - 98.82%Cor e Forma:SolidPeso molecular:696.84MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:412.85PRMT5-IN-36
CAS:PRMT5-IN-36 (compound 4), an orally active PRMT5 inhibitor, is utilized in cancer research studies.Fórmula:C20H15F3N6O2Peso molecular:428.37UNC7096
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1Fórmula:C61H87N7O18SPureza:98%Cor e Forma:SolidPeso molecular:1238.44CARM1 degrader-1
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).Fórmula:C71H98N12O8SPureza:98%Cor e Forma:SolidPeso molecular:1279.68MAK683-CH2CH2COOH hydrochloride
MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.Fórmula:C23H22ClFN6O3Cor e Forma:SolidPeso molecular:484.91FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Fórmula:C22H19ClFN5O2Cor e Forma:SolidPeso molecular:439.87OTS186935 FA
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.Fórmula:C26H28ClN5O4Pureza:99.52%Cor e Forma:SoildPeso molecular:509.98GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62ORIC-944 TFA
ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.Fórmula:C28H26F4N6O3Cor e Forma:SoildPeso molecular:570.54XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14EZH2-IN-22
CAS:EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.Fórmula:C36H50N4O8Cor e Forma:SolidPeso molecular:666.8EPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Fórmula:C29H33ClN8O3Cor e Forma:SolidPeso molecular:577.08SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Fórmula:C41H47ClN6O6SPureza:98%Cor e Forma:SolidPeso molecular:787.37SARS-CoV-2-IN-87
SARS-CoV-2-IN-87 (compound 138968421) is an effective inhibitor of the SARS-CoV-2 methyltransferases (nsp14 and nsp16).Fórmula:C26H40O6Peso molecular:448.28249UNC6852
CAS:<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Fórmula:C43H48N10O6SPureza:96.64%Cor e Forma:SolidPeso molecular:832.97EEDi-5285
CAS:<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Fórmula:C24H22FN5O3SPureza:100%Cor e Forma:SolidPeso molecular:479.53DNMT2-IN-2
DNMT2-IN-2 is a selective inhibitor of DNA methyltransferase 2 (DNMT2) with a KD value of 3.04 μM. It targets a concealed allosteric binding site of DNMT2 and reduces m5C levels in tRNA of MOLM-13 cells. This compound works synergistically with Doxorubicin to impair cell viability and is applicable in cancer research, including studies of cervical cancer and leukemia.Cor e Forma:Odour SolidNSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Fórmula:C21H25NO6Pureza:99.74%Cor e Forma:SolidPeso molecular:387.43PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Fórmula:C20H7Br6NO5Cor e Forma:SolidPeso molecular:820.702CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Fórmula:C39H61N5O7Cor e Forma:SolidPeso molecular:711.4571AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Fórmula:C36H41ClN6O3S2Cor e Forma:SolidPeso molecular:705.332MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Cor e Forma:Odour SolidWDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Cor e Forma:Odour SolidSAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Fórmula:C155H256N48O40Pureza:98%Cor e Forma:SolidPeso molecular:3432.05PRMT4-IN-2
PRMT4-IN-2 (compound 55) acts as a pan-inhibitor across various protein arginine methyltransferase (PRMT) isoforms, exhibiting inhibitory potencies with IC50Cor e Forma:Odour SolidCMP-5 2HCl
CAS:CMP-5 2HCl is a anthelmintic agent. CMP-5 2HCl shows EC100 of 5μM against H. contortus in vitro.Fórmula:C21H23Cl2N3Pureza:99.41%Cor e Forma:SoildPeso molecular:388.33MC3343
CAS:MC3343, a DNMT1/3A inhibitor, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation.Fórmula:C27H23N7OPureza:99.73%Cor e Forma:SolidPeso molecular:461.52MS115
MS115 is a selective PRMT5/MEP50 PROTAC degrader with DC50 values of 17.4 nM for PRMT5 and 11.3 nM for PRMT5 in MDAMB468 cells after 24 hours. MS115 also inhibits the proliferation of breast cancer cells.Cor e Forma:Odour SolidTet1 peptide
CAS:Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Fórmula:C73H114N20O17Cor e Forma:SolidPeso molecular:1543.81E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Fórmula:C21H36N6O2Cor e Forma:SolidPeso molecular:404.559Aclantate
CAS:Aclantate is a nonsteroidal anti-inflammatory drug.Fórmula:C15H14ClNO4SPureza:98%Cor e Forma:SolidPeso molecular:339.79Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Fórmula:C34H37ClF3N9O4SCor e Forma:SolidPeso molecular:760.23LLY-284
CAS:LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.Fórmula:C17H18N4O4Pureza:98%Cor e Forma:SolidPeso molecular:342.35NUCC-0226272
CAS:NUCC-0226272, a potent PROTAC, induces the degradation of EZH2 and exhibits anti-proliferative effects. It holds promise for application in cancer research [1].Fórmula:C67H91N9O8SPeso molecular:1182.56Gintemetostat
CAS:Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.Fórmula:C25H26F4N8O2Cor e Forma:SolidPeso molecular:546.522'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Fórmula:C9H13ClFN3O4Pureza:99.43%Cor e Forma:SolidPeso molecular:281.67AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Fórmula:C21H16N2O9S2Pureza:97.8%Cor e Forma:SolidPeso molecular:504.49PROTAC EZH2 Degrader-1
CAS:PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Fórmula:C54H67N7O8Cor e Forma:SolidPeso molecular:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Cor e Forma:SolidPeso molecular:532.12O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Fórmula:C24H34BrN5O7SPureza:98%Cor e Forma:SolidPeso molecular:616.53(R)-GSK-3685032
CAS:(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.Fórmula:C22H24N6OSCor e Forma:SolidPeso molecular:420.545-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:228.21DA-3003-1
CAS:DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Cor e Forma:SolidPeso molecular:321.76O6-Benzylguanine
CAS:Fórmula:C12H11N5OPureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:241.25EHMT2-IN-1
CAS:EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Fórmula:C18H23N7OCor e Forma:SolidPeso molecular:353.425'-Azido-5'-deoxyadenosine
CAS:5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.Fórmula:C10H12N8O3Pureza:99.84%Cor e Forma:SolidPeso molecular:292.25(R)-HH2853
CAS:(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Fórmula:C31H36F3N7O3Pureza:97.53% - 98.85%Cor e Forma:SolidPeso molecular:611.66EZM0414 TFA
CAS:EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Fórmula:C24H30F4N4O4Pureza:98.88%Cor e Forma:SolidPeso molecular:514.51PR5-LL-CM01
CAS:PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Fórmula:C23H27N7Cor e Forma:SolidPeso molecular:401.51EPZ020411
CAS:EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Fórmula:C25H38N4O3Cor e Forma:SolidPeso molecular:442.6AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Fórmula:C33H40Cl2F6N4O8Cor e Forma:SolidPeso molecular:805.59AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Fórmula:C26H28F3N5O3S2Pureza:98.96%Cor e Forma:SolidPeso molecular:579.66GSK591
CAS:GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Fórmula:C22H28N4O2Pureza:99.35% - 99.45%Cor e Forma:SolidPeso molecular:380.483-deazaneplanocin A HCl
CAS:<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Fórmula:C12H15ClN4O3Pureza:93.24% - 98.9%Cor e Forma:SolidPeso molecular:298.73MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Fórmula:C17H25N3OPureza:98.31% - 99.87%Cor e Forma:SolidPeso molecular:287.4SGC2085 HCl
CAS:<p>SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.</p>Fórmula:C19H24N2O2·HClPureza:99.91%Cor e Forma:SolidPeso molecular:348.87Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Fórmula:C30H42N8O3Pureza:99.19% - 99.86%Cor e Forma:SolidPeso molecular:562.71TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Fórmula:C28H34N4O2Pureza:97.85%Cor e Forma:SolidPeso molecular:458.6AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Fórmula:C21H14N2Na2O9S2Pureza:97.53% - 99.9%Cor e Forma:DrypowderPeso molecular:548.45Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Fórmula:C34H44N4O4Pureza:98.24% - ≥95%Cor e Forma:SolidPeso molecular:572.74MRTX9768
CAS:MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Fórmula:C24H17FN6OPureza:97.02%Cor e Forma:SolidPeso molecular:424.43LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Fórmula:C36H42N6OPureza:99.58% - 99.93%Cor e Forma:SolidPeso molecular:574.76OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Fórmula:C29H32F3N5O3Pureza:97.07% - 99.93%Cor e Forma:SolidPeso molecular:555.59BRD4770
CAS:<p>BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.</p>Fórmula:C25H23N3O3Pureza:99.82%Cor e Forma:SolidPeso molecular:413.47Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Fórmula:C9H12N2O5Pureza:99.04% - >99.99%Cor e Forma:SolidPeso molecular:228.2UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Fórmula:C29H44F2N6O2Pureza:98.75% - 99.5%Cor e Forma:SolidPeso molecular:546.7BRD9539
CAS:BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFórmula:C24H21N3O3Pureza:98% - 99.57%Cor e Forma:SolidPeso molecular:399.44EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Cor e Forma:SolidPeso molecular:369.4Succinic acid sodium
CAS:Succinic acid sodium is an orally active anxiolytic.Fórmula:C4H6O4·xNaCor e Forma:Solidγ-Oryzanol
CAS:γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFórmula:C40H58O4Pureza:mixture - mixtureCor e Forma:White Or White Crystalline Powder OdourlessPeso molecular:602.9MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Fórmula:C16H14N2OSPureza:99.77% - 99.85%Cor e Forma:SolidPeso molecular:282.36OTS186935 hydrochloride
OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.Fórmula:C25H27Cl2N5O2Cor e Forma:SolidPeso molecular:522.31EPZ004777
CAS:EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Fórmula:C28H41N7O4Pureza:98.99% - 99.32%Cor e Forma:SolidPeso molecular:539.67BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Cor e Forma:SolidPeso molecular:490.64UNC1215
CAS:<p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>Fórmula:C32H43N5O2Pureza:98% - 99.04%Cor e Forma:SolidPeso molecular:529.72MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Fórmula:C15H24N2OPureza:98.91%Cor e Forma:SolidPeso molecular:248.36SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Fórmula:C16H18N4O2Pureza:99.75% - 99.89%Cor e Forma:SolidPeso molecular:298.34AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Fórmula:C29H38Cl2N4O4Pureza:98.18%Cor e Forma:SolidPeso molecular:577.54Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Fórmula:C34H45BrN4O4Pureza:99.8%Cor e Forma:SolidPeso molecular:653.65CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Fórmula:C29H43Cl3N4O3Cor e Forma:SolidPeso molecular:602.04UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Fórmula:C36H59N7O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:621.9SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:618.57PF-06726304
CAS:PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).Fórmula:C22H21Cl2N3O3Pureza:98.19% - 99.51%Cor e Forma:SolidPeso molecular:446.33WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Fórmula:C21H25N3O4Pureza:98% - 99.61%Cor e Forma:SolidPeso molecular:383.44A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFórmula:C18H16Cl2N4Pureza:99.92%Cor e Forma:SolidPeso molecular:359.25Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Fórmula:C38H46O8Pureza:97.47% - 99.6%Cor e Forma:SolidPeso molecular:630.77EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Fórmula:C32H37N5O3Pureza:97.06% - 99.64%Cor e Forma:SolidPeso molecular:539.672',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Fórmula:C14H18N4O8Pureza:98.34%Cor e Forma:SolidPeso molecular:370.31
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