DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 450 produtos de "DNA Metiltransferase"
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1-Hydrazinophthalazine Hydrochloride
CAS:Fórmula:C8H8N4·HClPureza:>99.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:196.64Procaine Hydrochloride
CAS:Fórmula:C13H20N2O2·HClPureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:272.77Zebularine
CAS:Fórmula:C9H12N2O5Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:228.20(-)-Epigallocatechin Gallate Hydrate
CAS:Fórmula:C22H18O11·xH2OPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:458.38 (as Anhydrous)Chlorogenic Acid
CAS:Fórmula:C16H18O9Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:354.31N-Phthalyl-L-tryptophan
CAS:Fórmula:C19H14N2O4Pureza:>98.0%(T)(HPLC)Cor e Forma:Light yellow to Amber to Dark green powder to crystalinePeso molecular:334.33Genistein
CAS:Fórmula:C15H10O5Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:270.24Caffeic Acid
CAS:Fórmula:C9H8O4Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Orange to Green powder to crystalPeso molecular:180.165-Azacytidine
CAS:Fórmula:C8H12N4O5Pureza:>98.0%(T)Cor e Forma:White to Almost white powder to crystalPeso molecular:244.21Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Fórmula:C22H28ClN3O4Pureza:99.91%Cor e Forma:SolidPeso molecular:433.934-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O5Pureza:98%Cor e Forma:SolidPeso molecular:244.20475-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Fórmula:C8H12N4O5Pureza:98% - 99.79%Cor e Forma:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Cor e Forma:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Fórmula:C26H35FN4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:486.65Amodiaquine dihydrochloride dihydrate
CAS:<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Fórmula:C20H28Cl3N3O3Pureza:99.97%Cor e Forma:SolidPeso molecular:464.824H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:Fórmula:C15H10O5Pureza:97%Cor e Forma:SolidPeso molecular:270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgA consultar100g114,00€10kgA consultar250g181,00€500g320,00€100mg26,00€(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Fórmula:C16H18O9Pureza:98%Cor e Forma:SolidPeso molecular:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgA consultar25g153,00€100g489,00€250gA consultar500gA consultar50kg41.345,00€250mg26,00€Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Fórmula:C8H9ClN4Pureza:98%Cor e Forma:SolidPeso molecular:196.6369Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Fórmula:C9H16N4O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:292.25(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS:Fórmula:C22H18O11Pureza:98%Cor e Forma:SolidPeso molecular:458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgA consultar100g114,00€250g177,00€500g302,00€EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Fórmula:C34H48N4O4Pureza:99.74%Cor e Forma:SolidPeso molecular:576.774-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O4Pureza:98%Cor e Forma:SolidPeso molecular:228.2053Ref: IN-DA002NLT
1g99,00€5g255,00€10g563,00€25gA consultar50gA consultar5mg30,00€100gA consultar100mg31,00€250mg53,00€MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Fórmula:C20H17FN6OPureza:98.25% - 99.92%Cor e Forma:SolidPeso molecular:376.39BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Fórmula:C14H11NO3Pureza:98.87%Cor e Forma:SolidPeso molecular:241.24iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Cor e Forma:SoildPeso molecular:429.96Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFórmula:C8H14N2O2Pureza:99.67% - 99.86%Cor e Forma:White Crystalline PowderPeso molecular:170.21Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFórmula:C28H36ClN3O5SPureza:98.04% - 99.872%Cor e Forma:SolidPeso molecular:562.12Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Fórmula:C26H34ClN3O4Pureza:98.38% - 99.83%Cor e Forma:SolidPeso molecular:488.022(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS:Fórmula:C9H12N2O5Pureza:98%Cor e Forma:SolidPeso molecular:228.2020DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Fórmula:C25H25N3OPureza:98.95%Cor e Forma:SolidPeso molecular:383.49A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Fórmula:C29H38Cl2N4O4Cor e Forma:SolidPeso molecular:577.54PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Fórmula:C45H62Cl3N7O8Cor e Forma:SolidPeso molecular:935.37WDR5-47
CAS:WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Fórmula:C19H20ClFN4O3Pureza:98.15%Cor e Forma:SoildPeso molecular:406.84UNC6852
CAS:<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Fórmula:C43H48N10O6SPureza:96.64%Cor e Forma:SolidPeso molecular:832.97SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Fórmula:C155H256N48O40Pureza:98%Cor e Forma:SolidPeso molecular:3432.05FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Cor e Forma:Odour SolidDot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Cor e Forma:Odour SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Fórmula:C37H47N5O5SCor e Forma:SolidPeso molecular:673.32979XF056-132
CAS:XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Fórmula:C51H57F4N9O7SCor e Forma:SolidPeso molecular:1016.11
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