DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Fórmula:C34H44N4O4Pureza:98.24% - ≥95%Cor e Forma:SolidPeso molecular:572.74Ref: TM-T1788
2mg35,00€5mg52,00€10mg73,00€25mg92,00€50mg92,00€100mg153,00€500mg383,00€1mL*10mM (DMSO)66,00€SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Fórmula:C28H31N5O2Pureza:98.26% - 99.96%Cor e Forma:SolidPeso molecular:469.58HLCL-61 hydrochloride
CAS:HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Fórmula:C23H24N2O·ClHPureza:99.88% - 99.95%Cor e Forma:SolidPeso molecular:380.91MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Fórmula:C17H25N3OPureza:98.31% - 99.87%Cor e Forma:SolidPeso molecular:287.4Ref: TM-T6900
1mg39,00€2mg51,00€5mg88,00€10mg119,00€25mg243,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)84,00€RG108
CAS:RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Fórmula:C19H14N2O4Pureza:98% - 99.43%Cor e Forma:SolidPeso molecular:334.33Ref: TM-T2038
5mg47,00€10mg69,00€25mg117,00€50mg205,00€100mg286,00€200mg401,00€500mg652,00€1mL*10mM (DMSO)56,00€EPZ004777
CAS:EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Fórmula:C28H41N7O4Pureza:98.99% - 99.32%Cor e Forma:SolidPeso molecular:539.672',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Fórmula:C14H18N4O8Pureza:98.34%Cor e Forma:SolidPeso molecular:370.31Ref: TM-T7840
2mg40,00€5mg52,00€10mg80,00€25mg129,00€50mg187,00€100mg281,00€200mg406,00€1mL*10mM (DMSO)64,00€SGC707
CAS:SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Fórmula:C16H18N4O2Pureza:99.75% - 99.89%Cor e Forma:SolidPeso molecular:298.34BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Cor e Forma:SolidPeso molecular:490.64Ref: TM-T7697
1mg40,00€5mg85,00€10mg117,00€25mg207,00€50mg311,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)131,00€UNC1215
CAS:UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).Fórmula:C32H43N5O2Pureza:98% - 99.04%Cor e Forma:SolidPeso molecular:529.72MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Fórmula:C15H24N2OPureza:98.91%Cor e Forma:SolidPeso molecular:248.36Ref: TM-T4378
2mg35,00€5mg51,00€10mg85,00€25mg158,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)55,00€JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Fórmula:C22H23BrN6O2Pureza:98.86% - 99.98%Cor e Forma:SolidPeso molecular:483.36Ref: TM-T15624
1mg88,00€5mg170,00€10mg274,00€25mg567,00€50mg944,00€100mg1.659,00€1mL*10mM (DMSO)182,00€Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Fórmula:C34H45BrN4O4Pureza:99.8%Cor e Forma:SolidPeso molecular:653.65Ref: TM-T17002
2mg43,00€5mg60,00€10mg81,00€50mg96,00€100mg159,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)84,00€AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Fórmula:C29H38Cl2N4O4Pureza:98.18%Cor e Forma:SolidPeso molecular:577.54Ref: TM-TQ0100
1mg64,00€5mg137,00€10mg188,00€25mg311,00€50mg487,00€100mg658,00€1mL*10mM (DMSO)168,00€SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:618.57WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Fórmula:C21H25N3O4Pureza:98% - 99.61%Cor e Forma:SolidPeso molecular:383.44A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFórmula:C18H16Cl2N4Pureza:99.92%Cor e Forma:SolidPeso molecular:359.25Bobcat339
CAS:<p>Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.</p>Fórmula:C16H12ClN3OPureza:97.79% - 99.24%Cor e Forma:SolidPeso molecular:297.74UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Fórmula:C36H59N7O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:621.9Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Fórmula:C38H46O8Pureza:97.47% - 99.6%Cor e Forma:SolidPeso molecular:630.77Ref: TM-T8201
1mg49,00€5mg97,00€10mg160,00€25mg283,00€50mg452,00€100mg723,00€200mg938,00€1mL*10mM (DMSO)135,00€
