DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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MU1656
CAS:MU1656 is a selective inhibitor of histone methyltransferase DOT1L, which significantly inhibits cancer cell proliferation in hematological malignancies.Fórmula:C32H45N7O2Pureza:96.92%Cor e Forma:SolidPeso molecular:559.75MM-589
CAS:MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Fórmula:C28H44N8O5Pureza:98%Cor e Forma:SolidPeso molecular:572.70PRMT5-IN-32
CAS:PRMT5-IN-32, an inhibitor of PRMT5, inhibits HCT116 cell proliferation with an IC50 of 0.13 μM [1].Fórmula:C27H21F4N5O2Peso molecular:523.48EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Fórmula:C22H29FN4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:400.49LLY-283
CAS:LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Fórmula:C17H18N4O4Pureza:99.49%Cor e Forma:SolidPeso molecular:342.35AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Fórmula:C22H19F3N4O3Pureza:99.52%Cor e Forma:SolidPeso molecular:444.41GSK3368715 dihydrochloride
CAS:GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Fórmula:C20H40Cl2N4O2Pureza:99.66% - 99.66%Cor e Forma:SolidPeso molecular:439.46ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Fórmula:C26H25FN6OPureza:98.08%Cor e Forma:SolidPeso molecular:456.52Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFórmula:C15H23N7O5Pureza:98% - 98.12%Cor e Forma:SolidPeso molecular:381.39BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Fórmula:C21H22ClN5O4SPureza:99.85%Cor e Forma:SolidPeso molecular:475.95EHMT2-IN-2
CAS:EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.Fórmula:C21H22N6OCor e Forma:SolidPeso molecular:374.44CARM1-IN-1 hydrochloride
CAS:CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Fórmula:C26H22Br2ClNO3Cor e Forma:SolidPeso molecular:591.72BLL5 Maleate
CAS:BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Fórmula:C21H21N3Pureza:98%Cor e Forma:SolidPeso molecular:315.41Igermetostat
CAS:<p>Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].</p>Fórmula:C32H46N4O4Pureza:98%Cor e Forma:SolidPeso molecular:550.73BBDDL2059
CAS:<p>BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.</p>Fórmula:C27H36N4O4SPureza:98%Cor e Forma:SolidPeso molecular:512.66Ref: TM-T79200
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