DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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(2R)-Octyl-α-hydroxyglutarate sodium
CAS:(Sodium) (2R)-Octyl-α-hydroxyglutarate is the sodium salt variant of (2R)-Octyl-α-hydroxyglutarate, which has been shown to possess anti-inflammatory properties [1].Fórmula:C13H23NaO5Peso molecular:282.31YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFórmula:C23H34N4O3Cor e Forma:SolidPeso molecular:414.54MMSET-IN-1
CAS:MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Fórmula:C18H29N7O5Pureza:98%Cor e Forma:SolidPeso molecular:423.47NSD2-PWWP1-IN-1
CAS:NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Fórmula:C28H30N4Cor e Forma:SolidPeso molecular:422.565W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Fórmula:C25H36N6O3Cor e Forma:SolidPeso molecular:468.59O6BTG-C8-αGlu
CAS:O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Fórmula:C24H34BrN5O7SCor e Forma:SolidPeso molecular:616.525AMI-408
CAS:AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Fórmula:C20H13Cl2N6NaO5SCor e Forma:SolidPeso molecular:543.32PRMT5-IN-48
CAS:PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Fórmula:C30H37N5O3Cor e Forma:SolidPeso molecular:515.646EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Fórmula:C19H19FN8OCor e Forma:SolidPeso molecular:394.41CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Fórmula:C24H34Cl2N4O2Cor e Forma:SolidPeso molecular:481.46PRMT5-IN-1
CAS:PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).Fórmula:C19H19ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:418.83Dot1L-IN-1
CAS:The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Fórmula:C32H36ClN9O2SPureza:98%Cor e Forma:SolidPeso molecular:646.21HBI-2375
CAS:HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 µM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.Fórmula:C29H36ClF2N9O2Cor e Forma:SolidPeso molecular:616.11NSD2-PWWP1-IN-2
CAS:NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Fórmula:C29H30N4Cor e Forma:SolidPeso molecular:434.575RL5a
CAS:RL5a (compound C23) is a novel inhibitor of SETD8.Fórmula:C17H19N3OCor e Forma:SolidPeso molecular:281.35PRMT5-IN-49
CAS:PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Fórmula:C19H22N2O2Cor e Forma:SolidPeso molecular:310.39PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Fórmula:C32H42N4O4Cor e Forma:SolidPeso molecular:546.70PRMT5-IN-37
CAS:PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Fórmula:C21H15F4N5O2Cor e Forma:SolidPeso molecular:445.37EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.Fórmula:C23H23Cl2N3O3Cor e Forma:SolidPeso molecular:460.35RK-0080552
CAS:RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Fórmula:C12H6N6O2Cor e Forma:SolidPeso molecular:266.215
