Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 88 produtos de "Sirtuína"
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SRT 1720 dihydrochloride
CAS:<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Fórmula:C25H25Cl2N7OSPureza:98.58%Cor e Forma:SolidPeso molecular:542.48Ginkgolide C
CAS:<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Fórmula:C20H24O11Pureza:99.71% - 99.98%Cor e Forma:White PowderPeso molecular:440.4SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Fórmula:C22H20N4OS2Pureza:98.96% - 99.75%Cor e Forma:SolidPeso molecular:420.55Ganoderic acid D
CAS:<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>Fórmula:C30H42O7Pureza:98.06% - 99.98%Cor e Forma:SolidPeso molecular:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Cor e Forma:SolidPeso molecular:434.27Salermide
CAS:<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Cor e Forma:SolidPeso molecular:394.47Inauhzin
CAS:<p>Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).</p>Fórmula:C25H19N5OS2Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:469.58UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Fórmula:C16H13N3Pureza:98.31%Cor e Forma:SolidPeso molecular:247.29SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56Selisistat R-enantiomer
CAS:<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Fórmula:C13H13ClN2OPureza:99.8%Cor e Forma:SolidPeso molecular:248.71Ophiopogonin D'
CAS:<p>Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.</p>Fórmula:C44H70O16Pureza:99.77%Cor e Forma:SolidPeso molecular:855.02SRT 2104
CAS:<p>SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.</p>Fórmula:C26H24N6O2S2Pureza:98.34% - 99.82%Cor e Forma:SolidPeso molecular:516.64OSS_128167
CAS:<p>OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).</p>Fórmula:C19H14N2O6Pureza:97.47% - 98.6%Cor e Forma:SolidPeso molecular:366.32AGK7
CAS:<p>AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.</p>Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27SRT 2183
CAS:<p>SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).</p>Fórmula:C27H24N4O2SPureza:97.86%Cor e Forma:SolidPeso molecular:468.57AK-7
CAS:<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Cor e Forma:SolidPeso molecular:437.35Fisetin
CAS:<p>Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.</p>Fórmula:C15H10O6Pureza:94.14% - 99.05%Cor e Forma:Yellow To Brown Crystalline PowderPeso molecular:286.244'-bromo-Resveratrol
CAS:<p>4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)</p>Fórmula:C14H11BrO2Pureza:99.00%Cor e Forma:SolidPeso molecular:291.14SIRT7 inhibitor 97491
CAS:<p>SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.</p>Fórmula:C15H12ClN3OPureza:99.79%Cor e Forma:SolidPeso molecular:285.73Tenovin-6 Hydrochloride
CAS:<p>Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.</p>Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09
