Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 91 produtos para "Sirtuína".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Fórmula:C22H20N4OS2Pureza:99.52% - 99.75%Cor e Forma:SolidPeso molecular:420.55Ref: TM-T6984
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg102,00€25mg187,00€50mg295,00€100mg477,00€Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Fórmula:C30H42O7Pureza:98.06% - 99.98%Cor e Forma:White SolidPeso molecular:514.65AGK2
CAS:AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Cor e Forma:SolidPeso molecular:434.27Ref: TM-T6371
1mg34,00€2mg46,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg90,00€25mg177,00€50mg281,00€100mg444,00€500mg982,00€Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Cor e Forma:SolidPeso molecular:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Fórmula:C25H19N5OS2Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Fórmula:C16H13N3Pureza:98.31%Cor e Forma:SolidPeso molecular:247.29Ref: TM-T7679
1mg38,00€5mg77,00€1mL*10mM (DMSO)95,00€10mg110,00€25mg215,00€50mg306,00€100mg429,00€200mg600,00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Fórmula:C34H51N3O3SPureza:99.16%Cor e Forma:White SolidPeso molecular:581.85Ref: TM-T3447
1mg54,00€2mg73,00€5mg92,00€10mg117,00€1mL*10mM (DMSO)117,00€25mg215,00€50mg360,00€100mg537,00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Fórmula:C13H13ClN2OPureza:99.8%Cor e Forma:White SolidPeso molecular:248.71Ref: TM-T15263
1mg101,00€2mg150,00€5mg245,00€1mL*10mM (DMSO)269,00€10mg356,00€25mg597,00€50mg835,00€100mg1.108,00€Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Fórmula:C44H70O16Pureza:99.69% - 99.77%Cor e Forma:White SolidPeso molecular:855.02Ref: TM-TN1071
1mg114,00€5mg289,00€10mg432,00€1mL*10mM (DMSO)533,00€25mg692,00€50mg945,00€100mg1.251,00€SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Fórmula:C26H24N6O2S2Pureza:98.34% - 99.82%Cor e Forma:Yellow SolidPeso molecular:516.64Ref: TM-T6679
1mg43,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg533,00€200mg763,00€500mg1.161,00€1g1.558,00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Fórmula:C19H14N2O6Pureza:97.47% - 98.6%Cor e Forma:SolidPeso molecular:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Fórmula:C27H24N4O2SPureza:97.86%Cor e Forma:SolidPeso molecular:468.57Ref: TM-T16932
1mg52,00€2mg69,00€5mg102,00€1mL*10mM (DMSO)105,00€10mg157,00€25mg268,00€50mg408,00€100mg590,00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Cor e Forma:White SolidPeso molecular:437.35Ref: TM-T5490
1mg34,00€2mg47,00€5mg71,00€1mL*10mM (DMSO)89,00€10mg100,00€25mg177,00€50mg313,00€100mg512,00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Fórmula:C15H10O6Pureza:94.14% - 99.05%Cor e Forma:Yellow SolidPeso molecular:286.244'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Fórmula:C14H11BrO2Pureza:99.00%Cor e Forma:SolidPeso molecular:291.14CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Fórmula:C22H15FN4O2SPureza:98.92%Cor e Forma:SolidPeso molecular:418.44SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Fórmula:C15H12ClN3OPureza:99.79%Cor e Forma:SolidPeso molecular:285.73Ref: TM-T39233
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Ref: TM-T8480
1mg37,00€2mg49,00€5mg66,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg215,00€100mg356,00€
