Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 91 produtos para "Sirtuína".
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SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Fórmula:C26H29N5O4SPureza:98.25%Cor e Forma:SolidPeso molecular:507.6Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T4019
1mg38,00€2mg50,00€1mL*10mM (DMSO)63,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Cor e Forma:Yellow SolidPeso molecular:394.47Ref: TM-T6671
2mg40,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg170,00€50mg324,00€100mg482,00€500mg1.063,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.66%Cor e Forma:SolidPeso molecular:396.83MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Fórmula:C21H16BrCl2FN2O6S2Pureza:99.95% - 99.96%Cor e Forma:White SolidPeso molecular:626.3SIRT6 activator 12q
CAS:SIRT6 activator 12q is a SIRT6 activator; EC50=5.3 μM; allosteric modulator; metabolism and aging research.Fórmula:C31H22N2O2Pureza:98.53%Cor e Forma:White SolidPeso molecular:454.52SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Fórmula:C21H22N6OS2Pureza:97.6%Cor e Forma:Yellow SolidPeso molecular:438.57SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Fórmula:C21H28N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:460.55SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:White SolidPeso molecular:369.39SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Fórmula:C18H12Cl2N2O3SPureza:99.38% - 99.87%Cor e Forma:SolidPeso molecular:407.27Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69Ref: TM-T12920
1mg100,00€5mg203,00€1mL*10mM (DMSO)253,00€10mg323,00€25mg513,00€50mg697,00€100mg888,00€500mg1.783,00€SIRT2-IN-11
CAS:SIRT2-IN-11 is a selective SIRT2 inhibitor; IC50=12 nM; increases tubulin acetylation; cancer research tool.Fórmula:C21H22N2OCor e Forma:White SolidPeso molecular:318.412-APQC
CAS:2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.Fórmula:C23H24FN5OPureza:99.88%Cor e Forma:White SolidPeso molecular:405.47Ref: TM-T88667
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg212,00€25mg358,00€50mg512,00€100mg707,00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:White SolidPeso molecular:674.81Ref: TM-T12921
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)442,00€10mg502,00€25mg884,00€50mg1.288,00€100mg1.728,00€Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Fórmula:C31H32ClN5O2S2Pureza:99.63%Cor e Forma:Yellow SolidPeso molecular:606.2Epigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Fórmula:C32H34FN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:667.77SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFórmula:C21H30Br3ClN6SPureza:98%Cor e Forma:SolidPeso molecular:673.73Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Fórmula:C20H17N3O2Pureza:99.1% - 99.87%Cor e Forma:White SolidPeso molecular:331.37
