Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 88 produtos de "Sirtuína"
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SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Fórmula:C26H29N5O4SPureza:98.25%Cor e Forma:SolidPeso molecular:507.6Cambinol
CAS:<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Sirtinol
CAS:<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Cor e Forma:SolidPeso molecular:394.47B2
CAS:<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Fórmula:C20H17ClN4O3Pureza:99.66%Cor e Forma:SolidPeso molecular:396.83MDL-800
CAS:<p>MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.</p>Fórmula:C21H16BrCl2FN2O6S2Pureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:626.3SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87SIRT5 inhibitor 2
CAS:<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Fórmula:C18H12Cl2N2O3SPureza:99.38% - 99.87%Cor e Forma:SolidPeso molecular:407.27SIRT2-IN-9
CAS:<p>SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.</p>Fórmula:C21H22N6OS2Pureza:99.5%Cor e Forma:SolidPeso molecular:438.57SIRT5 inhibitor 6
CAS:<p>SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.</p>Fórmula:C21H28N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:460.55Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:SolidPeso molecular:369.39SIRT5 inhibitor 1
CAS:<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:SolidPeso molecular:674.81SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32Sirtuin modulator 1
CAS:<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Fórmula:C31H32ClN5O2S2Pureza:99.63%Cor e Forma:SolidPeso molecular:606.2WAY-354574
CAS:<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Fórmula:C20H23ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:406.93Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Fórmula:C20H17N3O2Pureza:99.1%Cor e Forma:SolidPeso molecular:331.37Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Fórmula:C32H34FN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:667.77SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Fórmula:C40H54N8O6SPureza:98%Cor e Forma:SolidPeso molecular:774.97SIRT5 inhibitor 7
CAS:<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Fórmula:C28H32ClN7O3SPureza:99.77%Cor e Forma:SolidPeso molecular:582.12SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Fórmula:C19H27N5O2SPureza:99.29%Cor e Forma:SolidPeso molecular:389.52
