Endocrinologia/Hormónios
Os inibidores de endocrinologia/hormônios são compostos que bloqueiam a ação dos hormônios ou interferem nas vias de sinalização hormonal. Esses inibidores são essenciais para estudar a regulação dos sistemas endócrinos e para desenvolver tratamentos para doenças relacionadas aos hormônios, como diabetes, distúrbios da tireoide e cânceres dependentes de hormônios. Ao modular a atividade hormonal, esses inibidores podem ajudar a elucidar as complexas interações dentro do sistema endócrino. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade para endocrinologia/hormônios para apoiar sua pesquisa em endocrinologia, farmacologia e ciências médicas.
Subcategorias de "Endocrinologia/Hormónios"
- Receptor de Androgénio(229 produtos)
- Anexina A(16 produtos)
- Aromatase(23 produtos)
- Receptor de estrogénio/progestagénio(66 produtos)
- GPR(1 produtos)
- Receptor de glicocorticoides(164 produtos)
- LHRH(2 produtos)
- Receptor opioide(327 produtos)
- Receptor de Prostaglandina(122 produtos)
- RAAS(89 produtos)
- Redutase(51 produtos)
- Somatostatina(57 produtos)
- Receptor de hormónio tireoidiano (THR)(34 produtos)
- Receptor de Vasopressina(48 produtos)
Exibir 6 mais subcategorias
Foram encontrados 3419 produtos de "Endocrinologia/Hormónios"
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AMG 837 calcium hydrate
CAS:AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.Fórmula:C52H44CaF6O8Pureza:98.07%Cor e Forma:SolidPeso molecular:950.97BU72
CAS:BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.Fórmula:C28H32N2O2Cor e Forma:SolidPeso molecular:428.57Sob-AM2
CAS:Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).Fórmula:C21H27NO3Cor e Forma:SolidPeso molecular:341.44FSH receptor antagonist 1
CAS:FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.Fórmula:C33H32N2O2Cor e Forma:SolidPeso molecular:488.619C108297
CAS:C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.Fórmula:C30H36FN3O4SPureza:98%Cor e Forma:SolidPeso molecular:553.69Androgen receptor antagonist 11
CAS:Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.Fórmula:C20H19F3N4O3SCor e Forma:SolidPeso molecular:452.45LNS8801
CAS:LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.Fórmula:C21H18BrNO3Cor e Forma:SolidPeso molecular:412.277Dazucorilant
CAS:Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.Fórmula:C29H22F4N4O3SCor e Forma:SolidPeso molecular:582.57Glucocorticoid receptor activator 1
CAS:Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.Fórmula:C11H15Cl2NO2Cor e Forma:SolidPeso molecular:264.15GPR81 agonist 2
CAS:GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Fórmula:C26H27ClN6O5S2Cor e Forma:SolidPeso molecular:603.1121-Deacetoxy deflazacort
CAS:21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.Fórmula:C23H29NO4Cor e Forma:SolidPeso molecular:383.48Androgen receptor antagonist 12
CAS:Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Fórmula:C12H8F3N3O2Cor e Forma:SolidPeso molecular:283.21LX1
CAS:LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Fórmula:C22H15F6NO2Cor e Forma:SolidPeso molecular:439.35Androgen receptor degrader-5
CAS:Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Fórmula:C29H25F4N5O2Cor e Forma:SolidPeso molecular:551.53FL442
CAS:FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Fórmula:C15H13F3N2OCor e Forma:SolidPeso molecular:294.27GLPG0492 (R enantiomer)
CAS:GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.Fórmula:C19H14F3N3O3Cor e Forma:SolidPeso molecular:389.33AVE 0991
CAS:AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.Fórmula:C29H32N4O5S2Pureza:99.73%Cor e Forma:SolidPeso molecular:580.72AP5 sodium
CAS:AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.Fórmula:C28H27FNNaO4Cor e Forma:SolidPeso molecular:483.515LY2066948
CAS:LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.Fórmula:C30H31NO5SCor e Forma:SolidPeso molecular:517.64(+)-JJ-74-138
CAS:(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).Fórmula:C22H22F8N2OSCor e Forma:SolidPeso molecular:514.48
