Redutase
Redutases são uma ampla classe de enzimas que catalisam a redução de moléculas em várias vias bioquímicas. Em endocrinologia, redutases específicas, como a 5α-redutase, são cruciais para o metabolismo dos hormônios esteroides, incluindo a conversão de testosterona em diidrotestosterona (DHT). Inibidores de enzimas redutases são usados no tratamento de condições como hiperplasia prostática benigna e alopecia androgênica. Na CymitQuimica, oferecemos uma variedade de inibidores de redutase de alta qualidade para apoiar sua pesquisa em regulação hormonal, vias metabólicas e desenvolvimento terapêutico.
Foram encontrados 59 produtos para "Redutase".
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AY 9944
CAS:AY 9944 inhibits DHCR7 enzyme (IC50=13 nM) and sterol isomerase, leading to hypocholesterolemia and 7DHC buildup.Fórmula:C22H30Cl4N2Pureza:98.92% - 99.65%Cor e Forma:White SolidPeso molecular:464.3Zenarestat
CAS:Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.Fórmula:C17H11BrClFN2O4Pureza:99.51% - 99.51%Cor e Forma:White SolidPeso molecular:441.636SN34037
CAS:SN34037, specific Aldo-keto reductase 1C3 (AKR1C3) inhibitor, inhibiting the cytotoxic activity of PR-104A, suitable for studying PR-104A-responsive leukaemia.Fórmula:C15H19Cl2N3O2Pureza:99.03%Cor e Forma:Yellow SolidPeso molecular:344.24Fidarestat
CAS:Fidarestat (SNK 860),Aldose reductase inhibitor (IC50=26 nM). Targets AKR1B10 (33 μM) and V301L AKR1B10 (1.8 μM). Potential diabetes treatment.Fórmula:C12H10FN3O4Pureza:98%Cor e Forma:White SolidPeso molecular:279.2239AKR1C3-IN-14
CAS:AKR1C3-IN-14 (compound 4) is an inhibitor of AKR1C3 enzyme, exhibiting an IC50 value of 0.122 μM. It reduces excess androgen production by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. Additionally, AKR1C3-IN-14 plays a role in the biosynthesis of prostaglandin PGF2α, influencing this pathway to regulate cell proliferation. This compound is utilized in the research of prostate cancer.Fórmula:C21H21BrN2O4Peso molecular:445.31Aldose reductase-IN-6
CAS:Aldose reductase-IN-6 is an AR inhibitor; blocks polyol pathway; reduces sorbitol; diabetic complications research tool.Fórmula:C20H16N4O2SPureza:99.63%Cor e Forma:White SolidPeso molecular:376.43Risarestat
CAS:Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.Fórmula:C16H21NO4SPureza:98.39%Cor e Forma:SolidPeso molecular:323.407Minalrestat
CAS:Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.Fórmula:C19H11BrF2N2O4Pureza:98.64% - 99.88%Cor e Forma:SolidPeso molecular:449.2Lidorestat
CAS:Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity.Fórmula:C18H11F3N2O2SPureza:99.98%Cor e Forma:SolidPeso molecular:376.352Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Fórmula:C6H11N3O4Pureza:99.8%Cor e Forma:SolidPeso molecular:189.1692Izonsteride
CAS:Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride isFórmula:C24H26N2OS2Pureza:99.5%Cor e Forma:SolidPeso molecular:422.606Zopolrestat
CAS:Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).Fórmula:C19H12F3N3O3SPureza:99.74% - 99.82%Cor e Forma:SolidPeso molecular:419.377Ranirestat
CAS:Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathyFórmula:C17H11BrFN3O4Pureza:96.10% - 99.44%Cor e Forma:SolidPeso molecular:420.189ALR2-IN-10
CAS:ALR2-IN-10 (Compound 23) is a weak inhibitor of aldose reductase 2 (Aldose Reductase2), showing an inhibition rate of 6% at a concentration of 27 μM. It is applicable in research related to diabetic complications.Fórmula:C21H15NO2Peso molecular:313.3493ALR2-IN-7
CAS:ALR2-IN-7 (Compound 5a) is a potent and selective inhibitor of alditol reductase (ALR2/AKR1B1) with a Ki of 8.71 nM. It holds potential for research into diabetic complications such as retinopathy and nephropathy, as well as cancer.Fórmula:C17H15NO3Cor e Forma:SolidPeso molecular:281.3059NSC 645827
CAS:NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), with an IC50 of 0.7 μM.Fórmula:C17H17N5O2Cor e Forma:SolidPeso molecular:323.349RJG-2051
CAS:RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.Fórmula:C26H31N5O4SCor e Forma:SolidPeso molecular:509.62N-(3-Methylphenyl)anthranilic acid
CAS:N-(3-Methylphenyl)anthranilic acid is an inhibitor of aldo-keto reductase 1C3 (AKR1C3) and AKR1C2 with IC50 values of 0.24 μM and 0.38 μM, respectively. It does not inhibit COX-1 or COX-2. This compound can be utilized in research on castration-resistant prostate cancer.Fórmula:C14H13NO2Peso molecular:227.2585(Rac)-Fidarestat
CAS:(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.Fórmula:C12H10FN3O4Cor e Forma:SolidPeso molecular:279.224
