Enzima
Os inibidores de enzimas são moléculas que se ligam a enzimas e diminuem sua atividade. Esses inibidores são amplamente utilizados em pesquisas para estudar a cinética enzimática, regulação e o papel de enzimas específicas nas vias metabólicas. Os inibidores de enzimas também são cruciais no desenvolvimento de medicamentos, pois muitos agentes terapêuticos funcionam inibindo enzimas envolvidas em processos patológicos. Ao direcionar enzimas, esses inibidores podem modular vias bioquímicas e oferecer tratamentos potenciais para várias doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de enzimas de alta qualidade para apoiar sua pesquisa em bioquímica, farmacologia e descoberta de medicamentos.
Subcategorias de "Enzima"
- Anidrase carbónica(196 produtos)
- Hidroxilase(36 produtos)
- MPO(2 produtos)
- Redutase(51 produtos)
- Tirosinase(71 produtos)
Foram encontrados 3620 produtos de "Enzima"
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Girentuximab
CAS:Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).Cor e Forma:LiquidPeso molecular:145.55 kDaThrombopoietin Protein, Mouse, Recombinant
Expression system: E. coli
Length: 22-195, Partial
Activity: Cell ActivityCor e Forma:Lyophilized PowderPeso molecular:18.7 kDa (Predicted)TSPO/Carbonic Anhydrase Modulator 1
TSPO/Carbonic Anhydrase Modulator 1 (Compound 3) acts as a dual modulator of mitochondrial translocator protein and carbonic anhydrase, with a TSPOKi of 1.340 μM and a CAVII KA of 10.7 μM. It enhances neurosteroid production, increases BDNF gene expression, and demonstrates neuroprotective activity.Fórmula:C35H51N3O3Cor e Forma:SolidPeso molecular:561.798hCAI/II/IV-IN-28
CAS:hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.Fórmula:C14H15N3O3SPureza:98.25%Cor e Forma:SolidPeso molecular:305.35Tyrosinase-IN-14
Tyrosinase-IN-14 (compound 7m), a tyrosinase inhibitor, modulates the enzyme's secondary structure to diminish its catalytic function, exhibits low cytotoxicityFórmula:C21H13Br2N3O3SPureza:98%Cor e Forma:SolidPeso molecular:547.22Dorzolamide
CAS:Dorzolamide is an anti-glaucoma agent and is a carbonic anhydrase inhibitor.
Fórmula:C10H16N2O4S3Pureza:98%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:324.44CA IX/VEGFR-2-IN-3
CAIX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. It exhibits anticancer activity by inhibiting the growth of MCF-7 breast cancer cells (IC50 of 22.33 μM) and mouse fibroblast cell line 3T3, where cell viability is reduced to below 40% at a concentration of 100 μM. This compound is applicable for research in the field of cancer treatment.Fórmula:C19H16ClN3O5S2Cor e Forma:SolidPeso molecular:465.93Carbonic anhydrase inhibitor 32
Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.Fórmula:C17H16N6O3SCor e Forma:SolidPeso molecular:384.41CA inhibitor 2
Compound 4H is a potent carbonic anhydrase inhibitor with an IC50 value of 0.033 μM [1].Fórmula:C7H9N7O3S3Pureza:98%Cor e Forma:SolidPeso molecular:335.39hCAIX-IN-17
hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.Fórmula:C19H18N2O3SCor e Forma:SolidPeso molecular:354.42VM4-037
CAS:VM4-037 is a PET imaging agent used for carbonic anhydrase IX.Fórmula:C26H29FN6O7S2Cor e Forma:SolidPeso molecular:620.67Tyrosinase-IN-40
Tyrosinase-IN-40 (Compound 9r) is a competitive inhibitor of tyrosinase, boasting an IC50 value of 17.02 µM and a Ki value of 14.87 µM. This compound also exhibits antioxidant activity and can be utilized in studies related to melanin.Fórmula:C34H29N9O10Cor e Forma:SolidPeso molecular:723.648hCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2.Fórmula:C24H28N6O6SPureza:98%Cor e Forma:SolidPeso molecular:528.58Carbonic anhydrase
CAS:Carbonic anhydrase, a zinc enzyme in all life forms, converts CO2 to bicarbonate; studied for cancer, glaucoma, obesity, epilepsy.Cor e Forma:SolidIOX2-NH2-1
CAS:IOX2-NH2-1 inhibits E. coli EGLN-3 (prolyl hydroxylase) with an IC50 of 0.02–1 μM.Fórmula:C19H17N3O5Pureza:98.77% - 99.91%Cor e Forma:SoildPeso molecular:367.36Carbonic anhydrase inhibitor 29
Carbonic anhydrase inhibitor29 (Compound 5d) is an inhibitor targeting carbonic anhydrase IX and XII, with an inhibition constant (Ki) of 26.6 nM for carbonic anhydrase IX and a Ki of 10.9 nM for carbonic anhydrase XII. Carbonic anhydrase inhibitor29 can be used in cancer research.Cor e Forma:Odour SolidCAXII-IN-2
CAXII-IN-2 (compound 3j) is a highly effective inhibitor of CAXII. It demonstrates inhibitory activity against CA IX and CAXII, with Ki values of 27.4 nM and 4.0 nM, respectively.Fórmula:C16H13FNO4PCor e Forma:SolidPeso molecular:333.05662hCAI/II-IN-10
hCAI/II-IN-10 (Compound 5d) is an inhibitor of human carbonic anhydrase I and II (hCA I and hCA II), with IC50 values of 4.32 nM and 3.89 nM, respectively.Fórmula:C24H17Cl2N3O3S2Cor e Forma:SolidPeso molecular:530.446Butobendine
CAS:Butobendine is a compound derived from gallic acid and exhibits significant antiarrhythmic activity.Fórmula:C32H48N2O10Cor e Forma:SolidPeso molecular:620.73Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Fórmula:C7H6ClN3O4S2Pureza:98.46% - 98.91%Cor e Forma:Crystals Physical Description Crystals; White Powder (Ntp 1992)Peso molecular:295.72hCAIX-IN-19
hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/Cor e Forma:Odour SolidPeroxidase
CAS:Pureza:≥ 85units/mg (dry basis)Cor e Forma:Beige to light-brown, reddish brown or dark brown lyophilised powderPeso molecular:-[Asp371]-Tyrosinase (369-377), human
CAS:Tyrosinase (369-377,YMDGTMSQV) originates from tyrosinase and needs TAP and proteosome for cell presentation.Fórmula:C42H66N10O16S2Pureza:98%Cor e Forma:SolidPeso molecular:1031.16hCAII-IN-7
hCAII-IN-7 (R-13) inhibits human CA I, II, IV, IX with K i of 60.7, 320.7, 2298, 35.2 nM respectively.Fórmula:C20H25N3O4SCor e Forma:SolidPeso molecular:403.5Tyrosinase-IN-26
Tyrosinase-IN-26 (compound 13) is a non-competitive inhibitor of tyrosinase, with an IC50 value of 68.86 µM. It is capable of inhibiting melanin production.Fórmula:C25H24N2O6Peso molecular:448.16344hCAII/IX-IN-1
hCAII/IX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX, with Ki values of 7.4 nM and 7.0 nM, respectively. It plays a significant role in cancer research.Fórmula:C23H22N4O7S2Cor e Forma:SolidPeso molecular:530.573hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Fórmula:C22H20N4O6S2Cor e Forma:SolidPeso molecular:500.547Trypsin, bovine origin
CAS:Pureza:≥ 2000units/mg (USP)Cor e Forma:White or almost white crystalline powderPeso molecular:-hCAII-IN-6
"hCAII-IN-6 (S-13) inhibits hCA II (4.4 nM) and isoforms I, IV, IX (9.2, 480.2, 14.7 nM). For glaucoma research."Fórmula:C20H25N3O4SCor e Forma:SolidPeso molecular:403.5hCAIX/XII-IN-10
hCAIX/XII-IN-10 (compound DK-8) is an inhibitor of Carbonic Anhydrase, showing potent inhibitory activity against the tumor-associated membrane-bound isoforms hCA IX and XII, with Ki values of 32.5 nM and 29.2 nM, respectively.Fórmula:C17H13N3O5SPeso molecular:371.05759hCAIX/XII-IN-9
hCAIX/XII-IN-9 (compound 8) is a potent inhibitor of carbonic anhydrase (CA), with Ki values of 1658 nM for hCA I, 184.8 nM for hCA II, 8.9 nM for hCA IX, and 64.8 nM for hCA XII.Fórmula:C26H25N5O5S2Peso molecular:551.12971Phenylsulfamide
CAS:Phenylsulfamide (Compound 10), acting as an inhibitor of human carbonic anhydrase-II (hCA-II), exhibits a dissociation constant (Kd) of 45.50 μM and anFórmula:C6H8N2O2SCor e Forma:SolidPeso molecular:172.2Pyrocatechol
CAS:Pyrocatechol, often known as catechol or benzene-1,2-diol, is a benzenediol, Pyrocatechol was produced at a large scale industrially, mainly as precursors to pesticides, flavors, and fragrances. Its sulfonic acid is often present in the urine of many mammals.Fórmula:C6H6O2Pureza:99.96%Cor e Forma:SolidPeso molecular:110.11Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFórmula:C47H64N14O10Cor e Forma:SolidPeso molecular:985.1(Iso)-Samixogrel
CAS:(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.Fórmula:C25H25ClN2O4SPureza:98.85%Cor e Forma:SolidPeso molecular:484.99TPT-004
TPT-004, a TPH inhibitor, exhibits superior pharmacokinetic and pharmacodynamic properties, and demonstrates efficacy in preclinical models for attenuatingCor e Forma:Odour SolidGZ22-4
GZ22-4 is a near-infrared (NIR) fluorescent probe with a high affinity for carbonic anhydrase IX (CAIX), exhibiting a dissociation constant (Kd) of 0.2 nM. It is applicable in studies for visualizing CAIX-positive tumors.Fórmula:C88H126F3N6NaO24S4Peso molecular:1858.75561Acesulfame
CAS:Acesulfame inhibits CA9/12 and can be used to study inflammation-related diseases.Fórmula:C4H5NO4SCor e Forma:SolidPeso molecular:163.15Proteinase K
CAS:Pureza:≥ 30units/mg (pH 7.5, 37°C, dried basis)Cor e Forma:White or almost white lyophilized powderPeso molecular:-Peroxidase, from horseradish, approx. 200 U/mg
CAS:Pureza:≥ 150U/mgCor e Forma:Beige to light-brown, reddish brown or dark brown lyophilised powderPeso molecular:-β-Glucosidase, from almonds
CAS:Pureza:approx. 90% (biuret)Cor e Forma:White to pale yellow or beige powderPeso molecular:-DPP IV/hCA II-IN-1
CAS:DPP IV/hCA II-IN-1: strong DPP IV & CA inhibitor, IC50=0.049μM (DPP IV), Ki=0.0361-3.034μM (CA II-IV).Fórmula:C17H20N2O5SCor e Forma:SolidPeso molecular:364.42CAII/CAXII-IN-1
CAII/CAXII-IN-1 (compound 8d) is an inhibitor of CAII and CAXII, with IC50 values of 0.38 µM for CAII and 0.61 µM for CAXII.Cor e Forma:Odour SolidTyrosinase-IN-38
Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.Cor e Forma:Odour SolidCalmodulin-dependent Protein Kinase II fragment 290-309
CAS:Fórmula:C103H185N31O24SPeso molecular:2273.83Anhydrotetracycline hydrochloride
CAS:Anhydrotetracycline (hydrochloride) is a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes.Fórmula:C22H23ClN2O7Pureza:98% - 98.90%Cor e Forma:SolidPeso molecular:462.88Chlorzolamide
CAS:CHLORZOLAMIDE is a sulfonamide-based inhibitor that exhibits cytotoxic effects on prostate cancer cells.Fórmula:C8H6ClN3O2S2Peso molecular:275.74hCAII-IN-8
CAS:Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.Fórmula:C15H16N2O5SPureza:99.73%Cor e Forma:SoildPeso molecular:336.36Ref: TM-T67774
5mg42,00€10mg64,00€25mg116,00€50mg167,00€100mg241,00€200mg339,00€1mL*10mM (DMSO)52,00€CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Fórmula:C18H19NO6SCor e Forma:SolidPeso molecular:377.41CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Cor e Forma:Odour SolidTPH1-IN-1
TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM.Fórmula:C21H18N6O4SCor e Forma:SolidPeso molecular:450.475,6-Dihydro-2H-pyran-2-one
CAS:5,6-Dihydro-2H-pyran-2-one is a carbonic anhydrase 1/9 inhibitor that inhibits KB cell viability.Fórmula:C5H6O2Cor e Forma:SolidPeso molecular:98.1Tyrosinase-IN-36
Tyrosinase-IN-36 is a moderately potent inhibitor of tyrosine, exhibiting an inhibition percentage of 42.75% compared to kojic acid at a concentration of 100 μM and possesses antioxidant activity.Cor e Forma:Odour SolidDOTA-XYIMSR-01
CAS:DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.Fórmula:C61H88N16O22S2Cor e Forma:SolidPeso molecular:1461.57Swertiajaponin
CAS:Swertiajaponin possesses antimicrobial activity.Fórmula:C22H22O11Pureza:99.85%Cor e Forma:SolidPeso molecular:462.4TrkA Protein, Canine, Recombinant (hFc)
TrkA Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:42.3 kDa (predicted); 55-61 kDa (reducing conditions)ErbB4 Protein, Human, Rhesus, Recombinant (hFc)
ErbB4 Protein, Human, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:96.6 kDa (predicted); 117 kDa (reducing conditions)Ref: TM-TMPY-02814
1mg4.207,00€5µg77,00€10µg109,00€20µg174,00€50µg350,00€100µg668,00€200µg1.017,00€500µg2.071,00€FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag.Pureza:97.5%Cor e Forma:Lyophilized PowderPeso molecular:35.6 kDa (predicted)HER3/ERBB3 Protein, Human, Recombinant (aa 20-643, His & Avi), Biotinylated
HER3/ERBB3 Protein, Human, Recombinant (aa 20-643, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:90-120 KDa (reducing condition)Mer Protein, Mouse, Recombinant (His & GST)
Mer Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Cor e Forma:Lyophilized PowderPeso molecular:61.7 kDa (predicted); 58 kDa (reducing conditions)TrkB Protein, Human, Recombinant (His)
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:99.3%Cor e Forma:Lyophilized PowderPeso molecular:45.7 kDa (predicted); 70-80 kDa (reducing condition, due to glycosylation)M 12325
CAS:M 12325 is used in the production of furosemide; rhinitis and occupational asthma were observed in workers from a lasamide production line.Fórmula:C7H5Cl2NO4SCor e Forma:White To Almost White Solid PowderPeso molecular:270.09TrkA Protein, Rabbit, Recombinant (His)
TrkA Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:43.4 kDa (predicted)
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