NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 390 produtos de "NF-κB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Fórmula:C56H56N6O6Cor e Forma:SolidPeso molecular:909.1SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Fórmula:C129H230N36O29S·XCF3COOHCor e Forma:SolidPeso molecular:2781.5 (free base)R-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Fórmula:C22H19N3O2S2Cor e Forma:SolidPeso molecular:421.54R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Fórmula:C54H70N8O7S2Cor e Forma:SolidPeso molecular:1007.31BIZ 114
CAS:BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.Fórmula:C24H40O3Cor e Forma:SolidPeso molecular:376.57DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6Hesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Fórmula:C29H36O15Pureza:99.53%Cor e Forma:Yellow PowderPeso molecular:624.59ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Fórmula:C19H17Cl3N4O2Cor e Forma:SolidPeso molecular:439.72RS 09
CAS:TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.Fórmula:C31H49N9O9Pureza:98%Cor e Forma:SolidPeso molecular:691.78SEMBL
CAS:SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.Fórmula:C12H11NO4Pureza:98%Cor e Forma:SolidPeso molecular:233.22Stachydrine Hydrochloride
CAS:Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.Fórmula:C7H14ClNO2Pureza:99.53% - 99.71%Cor e Forma:Light Yellow PastePeso molecular:179.64Dehydrodiisoeugenol
CAS:Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Fórmula:C20H22O4Pureza:99.97%Cor e Forma:SolidPeso molecular:326.39Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Fórmula:C42H72O13Pureza:99.77% - 99.78%Cor e Forma:SolidPeso molecular:785.01Ref: TM-T2873
2mg37,00€5mg52,00€10mg88,00€25mg131,00€50mg188,00€100mg279,00€500mg658,00€1mL*10mM (DMSO)87,00€Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Fórmula:C37H42Cl2N2O6Pureza:95% - 99.99%Cor e Forma:SolidPeso molecular:681.65Ginsenoside Rg6
CAS:Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFórmula:C42H70O12Pureza:97.34%Cor e Forma:SolidPeso molecular:767Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Cor e Forma:SolidPeso molecular:801.01Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Fórmula:C21H26O6Pureza:98.77% - 99.41%Cor e Forma:SolidPeso molecular:374.43Ref: TM-T4S1540
1mg44,00€5mg87,00€10mg137,00€25mg236,00€50mg385,00€100mg560,00€1mL*10mM (DMSO)102,00€2,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Fórmula:C8H8O3Pureza:99.75%Cor e Forma:Yellow PowderPeso molecular:152.15(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Fórmula:C16H16N6OPureza:98.44%Cor e Forma:SolidPeso molecular:308.34Ref: TM-T8692
1mg46,00€2mg62,00€5mg92,00€10mg152,00€25mg295,00€50mg442,00€100mg620,00€200mg875,00€1mL*10mM (DMSO)105,00€BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:99.36% - 99.74%Cor e Forma:SolidPeso molecular:255.32
