NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 390 produtos de "NF-κB"
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ETHYL CAFFEATE
CAS:Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.Fórmula:C11H12O4Pureza:97.79%Cor e Forma:SolidPeso molecular:208.21Ref: TM-T6S1371
1mg49,00€5mg92,00€10mg133,00€25mg259,00€50mg358,00€100mg530,00€200mg755,00€1mL*10mM (DMSO)100,00€Denosumab
CAS:Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligandFórmula:C6404H9912N1724O2004S50Pureza:95.9% (SDS-PAGE); 98.4% (SEC-HPLC) - 99.90%Cor e Forma:LiquidPeso molecular:144.71 kDaJTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Fórmula:C17H13NaO4Pureza:99.95%Cor e Forma:SolidPeso molecular:304.27Ref: TM-T8951
1mg37,00€2mg50,00€5mg65,00€10mg95,00€25mg210,00€50mg339,00€100mg495,00€500mg1.099,00€1mL*10mM (DMSO)77,00€Diethylmaleate
CAS:Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.Fórmula:C8H12O4Pureza:98%Cor e Forma:Colourless LiquidPeso molecular:172.18Chelidonic acid
CAS:Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Fórmula:C7H4O6Pureza:99.03%Cor e Forma:SolidPeso molecular:184.10Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).Fórmula:C141H210N32O44SPureza:98%Cor e Forma:SolidPeso molecular:3089.43Sinomenine
CAS:Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
Fórmula:C19H23NO4Pureza:99.02% - 99.73%Cor e Forma:White PowderPeso molecular:329.39ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Fórmula:C32H22O10Pureza:98% - 99.75%Cor e Forma:SolidPeso molecular:566.51AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.
Fórmula:C40H52O4Pureza:95.1% - 99.79%Cor e Forma:Needles From Acetone/Light Petroleum SolidPeso molecular:596.84Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Fórmula:C29H31NO7Pureza:95.32% - 99.67%Cor e Forma:SolidPeso molecular:505.56Ref: TM-TQ0131
1mg187,00€5mg410,00€10mg710,00€25mg1.381,00€50mg2.352,00€500µg155,00€1mL*10mM (DMSO)449,00€Ethacrynic acid
CAS:Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。Fórmula:C13H12Cl2O4Pureza:98.61% - 99.85%Cor e Forma:Crystals Physical Description White Solid (Ntp 1992)Peso molecular:303.14Quinoclamine
CAS:Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.Fórmula:C10H6ClNO2Pureza:99.13% - 99.28%Cor e Forma:Orange PowderPeso molecular:207.617,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:SolidPeso molecular:254.24Rucaparib
CAS:Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Fórmula:C19H18FN3OPureza:98.24% - 99.80%Cor e Forma:SolidPeso molecular:323.36Ref: TM-T4463
2mg46,00€5mg70,00€10mg109,00€25mg170,00€50mg222,00€100mg344,00€200mg512,00€500mg823,00€1mL*10mM (DMSO)77,00€Geranylgeraniol
CAS:Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice.Fórmula:C20H34OPureza:99.17% - ≥98%Cor e Forma:SolidPeso molecular:290.48Adelmidrol
CAS:Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Fórmula:C13H26N2O4Pureza:99.35% - 99.73%Cor e Forma:SolidPeso molecular:274.3614-Deoxy-11,12-didehydroandrographolide
CAS:14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.Fórmula:C20H28O4Pureza:99.13% - 99.93%Cor e Forma:SolidPeso molecular:332.43Ref: TM-TQ0185
1mg65,00€5mg152,00€10mg215,00€25mg355,00€50mg530,00€100mg735,00€1mL*10mM (DMSO)138,00€Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Fórmula:C19H18FN3O·H3PO4Pureza:99.37%Cor e Forma:SolidPeso molecular:421.36Ref: TM-T6127
1mg35,00€2mg50,00€5mg74,00€10mg109,00€25mg178,00€50mg235,00€100mg371,00€200mg553,00€1mL*10mM (DMSO)74,00€Damascenone
CAS:Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.Fórmula:C13H18OPureza:99.81%Cor e Forma:Colorless LiquidPeso molecular:190.2820(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Fórmula:C42H72O13Pureza:98.11% - 99.93%Cor e Forma:SolidPeso molecular:785.012,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFórmula:C4H6N4OPureza:99.82%Cor e Forma:White Solid CrystalsPeso molecular:126.12Andrographolide
CAS:Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFórmula:C20H30O5Pureza:99.39% - 99.97%Cor e Forma:PowderPeso molecular:350.458-Deoxygartanin
CAS:8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it hasFórmula:C23H24O5Pureza:99.04% - 99.88%Cor e Forma:SolidPeso molecular:380.43TAK-243
CAS:TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).Fórmula:C19H20F3N5O5S2Pureza:98.09% - 98.93%Cor e Forma:SolidPeso molecular:519.52Ref: TM-T16974
1mg46,00€2mg60,00€5mg90,00€10mg142,00€25mg254,00€50mg434,00€100mg623,00€1mL*10mM (DMSO)102,00€Caffeic Acid Phenethyl Ester
CAS:CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.Fórmula:C17H16O4Pureza:99.18% - 99.35%Cor e Forma:Less Transparent Liquid Colorless Transparent LiquidPeso molecular:284.31Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Fórmula:C30H48O3Pureza:98.22% - 99.7%Cor e Forma:White Crystalline PowderPeso molecular:456.70Indacaterol
CAS:Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.Fórmula:C24H28N2O3Pureza:99.96%Cor e Forma:SolidPeso molecular:392.49Rucaparib monocamsylate
CAS:Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.
Fórmula:C29H34FN3O5SPureza:99.82%Cor e Forma:SolidPeso molecular:555.66Tryptanthrin
CAS:Tryptanthrin is a natural DNA gyrase inhibitor.Fórmula:C15H8N2O2Pureza:99.64% - 99.94%Cor e Forma:SolidPeso molecular:248.24Sauchinone
CAS:Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Fórmula:C20H20O6Pureza:99.12% - >99.99%Cor e Forma:SolidPeso molecular:356.37Sanggenon C
CAS:Sanggenon C inhibits NF-κB activity, the expression of inducible nitric oxide synthase, tumor necrosis factor-α-stimulated cell adhesion and the expression of vascular cell adhesion molecule-1 in RAW264.7 cells. Cost-effective and quality-assured.Fórmula:C40H36O12Pureza:97.76% - 99.76%Cor e Forma:SolidPeso molecular:708.71Ref: TM-T4S1615
1mg88,00€5mg178,00€10mg268,00€25mg467,00€50mg665,00€100mg888,00€200mg1.234,00€1mL*10mM (DMSO)269,00€HOMOPLANTAGININ
CAS:Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and showsFórmula:C22H22O11Pureza:97.63% - 99.66%Cor e Forma:SolidPeso molecular:462.40SC75741
CAS:SC75741 is a potent P65 inhibitor with IC50 of 200 nMFórmula:C29H23N7O2S2Pureza:99.44% - 99.54%Cor e Forma:SolidPeso molecular:565.67Ref: TM-T6661
1mg40,00€5mg73,00€10mg105,00€25mg177,00€50mg281,00€100mg432,00€200mg618,00€1mL*10mM (DMSO)93,00€Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Fórmula:C6H9NOS2Pureza:97.55% - 99.67%Cor e Forma:Slightly Yellowish LiquidPeso molecular:175.27Ref: TM-TL0016
1mg34,00€2mg46,00€5mg66,00€10mg92,00€25mg167,00€50mg241,00€100mg359,00€200mg525,00€1mL*10mM (DMSO)65,00€Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Fórmula:C42H70O12Pureza:98% - 99.65%Cor e Forma:SolidPeso molecular:767.00Ref: TM-T6S1487
1mg107,00€5mg251,00€10mg404,00€25mg665,00€50mg888,00€100mg1.251,00€1mL*10mM (DMSO)341,00€WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Fórmula:C17H13F3N2O2Pureza:98.63% - 98.64%Cor e Forma:SolidPeso molecular:334.29Ref: TM-T8981
2mg39,00€5mg60,00€10mg92,00€25mg187,00€50mg313,00€100mg450,00€200mg620,00€1mL*10mM (DMSO)89,00€Astilbin
CAS:Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Fórmula:C21H22O11Pureza:97% - 99.86%Cor e Forma:White PowderPeso molecular:450.39Ref: TM-T2794
5mg49,00€10mg73,00€25mg133,00€50mg212,00€100mg316,00€200mg452,00€500mg737,00€1mL*10mM (DMSO)49,00€Praeruptorin A
CAS:Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulinFórmula:C21H22O7Pureza:99.63% - 99.65%Cor e Forma:SolidPeso molecular:386.4Tenuigenin
CAS:Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Fórmula:C30H45ClO6Pureza:98.9% - 99.53%Cor e Forma:SolidPeso molecular:537.13Ref: TM-T3907
2mg34,00€5mg50,00€10mg73,00€25mg105,00€50mg152,00€100mg215,00€200mg318,00€1mL*10mM (DMSO)63,00€Tectochrysin
CAS:Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Fórmula:C16H12O4Pureza:99.26%Cor e Forma:SolidPeso molecular:268.26INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3Picroside II
CAS:Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.Fórmula:C23H28O13Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:512.46Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Fórmula:C36H56O8Pureza:98.55% - >99.99%Cor e Forma:White To Off-White SolidPeso molecular:616.83Handelin
CAS:Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.Fórmula:C32H40O8Pureza:99.02% - 99.345%Cor e Forma:SolidPeso molecular:552.66Sciadopitysin
CAS:Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Fórmula:C33H24O10Pureza:98.67% - 99.17%Cor e Forma:SolidPeso molecular:580.54Ref: TM-T5S2129
1mg49,00€5mg89,00€10mg154,00€25mg288,00€50mg432,00€100mg620,00€500mg1.279,00€1mL*10mM (DMSO)123,00€Okanin
CAS:Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Fórmula:C15H12O6Pureza:95.19% - 99.4%Cor e Forma:SolidPeso molecular:288.25Ref: TM-TN2008
1mg84,00€5mg245,00€10mg295,00€25mg497,00€50mg710,00€100mg964,00€1mL*10mM (DMSO)207,00€Schisantherin A
CAS:Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.Fórmula:C30H32O9Pureza:98% - 99.989Cor e Forma:SolidPeso molecular:536.57
