NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 443 produtos de "NF-κB"
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DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39IKKβ-IN-1
CAS:<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Fórmula:C31H30N4O4SCor e Forma:SolidPeso molecular:554.66GSK319347A
CAS:<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53IMD-ferulic
<p>IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.</p>Fórmula:C36H41N7O4Cor e Forma:SolidPeso molecular:635.76Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Fórmula:C31H42N2O3Pureza:99.13% - >99.99%Cor e Forma:SolidPeso molecular:490.68Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Cor e Forma:SolidPeso molecular:447.6NF-κB-IN-2
CAS:<p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>Fórmula:C15H18O3Cor e Forma:SolidPeso molecular:246.3RIP2 Kinase Inhibitor 3
CAS:<p>RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.</p>Fórmula:C19H24N4O3SPureza:99.32% - 99.52%Cor e Forma:SolidPeso molecular:388.48Ro 106-9920
CAS:Inhibitor of NF-κB activationFórmula:C10H7N5OSPureza:98%Cor e Forma:SolidPeso molecular:245.26HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Cor e Forma:SolidPeso molecular:401.87Avenanthramide-C methyl ester
CAS:<p>Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).</p>Fórmula:C17H15NO6Cor e Forma:SolidPeso molecular:329.3Bay 65-1942 hydrochloride
CAS:<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91SZM679
<p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>Fórmula:C27H18F5N3O5SPureza:98%Cor e Forma:SolidPeso molecular:591.51NF-κB-IN-11
CAS:<p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>Fórmula:C19H18O5Pureza:98%Cor e Forma:SolidPeso molecular:326.34IMD-biphenylA
CAS:<p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>Fórmula:C35H33N5O2Pureza:98%Cor e Forma:SolidPeso molecular:555.67CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55NF-κB-IN-8
CAS:<p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>Fórmula:C24H21N3O3Pureza:98%Cor e Forma:SolidPeso molecular:399.44HS271
CAS:<p>HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).</p>Fórmula:C21H24F3N5O2Pureza:98.79%Cor e Forma:SolidPeso molecular:435.44GSK2983559 free acid
CAS:<p>GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.</p>Fórmula:C21H23N4O7PS2Pureza:97.8700% - 98.61%Cor e Forma:SolidPeso molecular:538.53SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Fórmula:C14H5ClF9N3OPureza:99.79%Cor e Forma:SolidPeso molecular:437.65
