CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 147 produtos para "CCR".
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GSK163929
CAS:GSK163929 (compound 122) is an orally active CCR5 antagonist with anti-HIV properties and demonstrates low inhibitory potency against hEGR. Administered at a dosage of 2000 mg/kg/day (i.v., 7 d), it shows no adverse effects in rats, and at 250 mg/kg/day (i.v., 7 d), it is similarly non-toxic in dogs.Fórmula:C36H40ClF2N5O3SCor e Forma:SolidPeso molecular:696.25CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:99.51%Cor e Forma:SolidPeso molecular:495.59Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.574WAY-639418
CAS:WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.Fórmula:C17H16ClN5Pureza:99.89%Cor e Forma:Yellow SolidPeso molecular:325.8Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidNI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Pureza:95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.83 kDaCKLF1-C27 TFA
CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.Fórmula:C153H244F3N39O39Cor e Forma:SolidPeso molecular:3310.8Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Cor e Forma:Odour SolidRS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Fórmula:C21H21F3N2O2Pureza:97.64% - 99.80%Cor e Forma:SolidPeso molecular:390.4RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Cor e Forma:White SolidPeso molecular:383.27RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.64% - 99.68%Cor e Forma:SolidPeso molecular:417.5Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Fórmula:C22H21ClN2NaO4SCor e Forma:SolidPeso molecular:467.92Vicriviroc
CAS:Vicriviroc, also known as MK4176 is a CCR5 antagonist.Fórmula:C28H38F3N5O2Cor e Forma:SolidPeso molecular:533.63ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Fórmula:C21H28N2O3Pureza:99.43%Cor e Forma:White SolidPeso molecular:356.46BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Fórmula:C21H24ClFN4O3Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:434.89Ref: TM-T2375
1mg35,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg117,00€25mg200,00€50mg313,00€100mg489,00€200mg740,00€PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Cor e Forma:SolidPeso molecular:568.59DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Fórmula:C35H56N10O15Pureza:>99.99%Cor e Forma:White SolidPeso molecular:856.887,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:White SolidPeso molecular:254.24C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Fórmula:C27H41N5O2Pureza:99.74% - 99.90%Cor e Forma:White SolidPeso molecular:467.65Ref: TM-T21870
1mg49,00€2mg67,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg144,00€25mg286,00€50mg444,00€100mg622,00€
