Nrf2
Nrf2 é um fator de transcrição que regula a expressão de proteínas antioxidantes e enzimas de desintoxicação, desempenhando um papel fundamental na defesa celular contra o estresse oxidativo e a inflamação. A ativação da sinalização Nrf2 oferece proteção contra várias doenças, incluindo câncer, neurodegeneração e distúrbios cardiovasculares. Os moduladores de Nrf2 estão sendo explorados por suas potenciais aplicações terapêuticas na redução de danos oxidativos e inflamação. Na CymitQuimica, oferecemos uma gama de moduladores da via Nrf2 de alta qualidade para apoiar sua pesquisa em estresse oxidativo, inflamação e prevenção de doenças.
Foram encontrados 82 produtos de "Nrf2"
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(+)-DHMEQ
CAS:(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.Fórmula:C13H11NO5Cor e Forma:SolidPeso molecular:261.23AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFórmula:C11H13ClO3S2Pureza:98%Cor e Forma:SolidPeso molecular:292.8MSU38225
CAS:MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.4Nrf2-Activator-12G
CAS:Nrf2-Activator-12G is a potent Nrf-2 activator.Fórmula:C15H13ClO3SPureza:98%Cor e Forma:SolidPeso molecular:308.78WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Fórmula:C20H26Cl3N5OCor e Forma:SolidPeso molecular:458.81Nrf2 activator-5
CAS:Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.Fórmula:C25H30Cl2O6Cor e Forma:SolidPeso molecular:497.41Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Fórmula:C30H29NO8SCor e Forma:SolidPeso molecular:563.62Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Fórmula:C8H16O2S2Pureza:97.51%Cor e Forma:Yellow To Orange LiquidPeso molecular:208.34Nrf2 activator-4
CAS:Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Fórmula:C23H24ClF3N2O3Pureza:98.53%Cor e Forma:SolidPeso molecular:468.9Stigmane B
<p>Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.</p>Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Fórmula:C29H30N2O7S2Pureza:98.43%Cor e Forma:SolidPeso molecular:582.69Keap1-Nrf2-IN-12
CAS:eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.Fórmula:C26H28N2O10S2Cor e Forma:SolidPeso molecular:592.64Keap1-Nrf2-IN-13
CAS:Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.Fórmula:C28H32N2O10S2Cor e Forma:SolidPeso molecular:620.69MIND4-17
CAS:MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.Fórmula:C20H15N5O3SCor e Forma:SolidPeso molecular:405.43SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38NXPZ-2
CAS:NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.Fórmula:C27H27N5O7S2Cor e Forma:SolidPeso molecular:597.66CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Fórmula:C33H46N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:518.73DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Fórmula:C14H9F2N3OPureza:99.85%Cor e Forma:SolidPeso molecular:273.24WRR139
CAS:WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1Fórmula:C25H32N2O4SCor e Forma:SolidPeso molecular:456.6Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFórmula:C30H34N4O8SCor e Forma:SolidPeso molecular:610.68Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Fórmula:C35H32N2O11S2Cor e Forma:SolidPeso molecular:720.77Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Cor e Forma:SolidPeso molecular:383.87Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Fórmula:C22H26N4O4SPureza:98.07%Cor e Forma:SolidPeso molecular:442.53Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Fórmula:C31H37ClFN5O5Cor e Forma:SolidPeso molecular:614.11Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Fórmula:C23H30N4O6SCor e Forma:SolidPeso molecular:490.57CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Cor e Forma:SolidPeso molecular:344.8KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Fórmula:C28H30N4O6SPureza:99.74%Cor e Forma:SolidPeso molecular:550.63NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Fórmula:C22H26Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:421.36
