CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 154 produtos de "CXCR"
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VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Fórmula:C31H39FN2O8Pureza:97.98%Cor e Forma:SolidPeso molecular:586.65Ref: TM-T13324
1mg43,00€2mg55,00€5mg88,00€10mg137,00€25mg273,00€50mg472,00€100mg680,00€200mg947,00€1mL*10mM (DMSO)97,00€LY2510924 acetate(1088715-84-7 free base)
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Fórmula:C64H91N13O13Pureza:97.32%Cor e Forma:SolidPeso molecular:1250.49Ref: TM-T15805L
1mg159,00€5mg306,00€10mg459,00€25mg750,00€50mg1.026,00€100mg1.415,00€1mL*10mM (DMSO)730,00€Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Fórmula:C99H145F4N33O21S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:2273.54Delmetacin
CAS:Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Fórmula:C18H15NO3Pureza:99.91%Cor e Forma:SolidPeso molecular:293.32Reparixin L-lysine salt
CAS:Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Fórmula:C20H35N3O5SPureza:99%Cor e Forma:SolidPeso molecular:429.57Quetmolimab
CAS:Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.Pureza:SDS-PAGE:95% SEC-HPLC:97.59%Cor e Forma:LiquidPeso molecular:150 kDaAMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Fórmula:C32H28F3N5O4Pureza:99.82% - 99.89%Cor e Forma:SolidPeso molecular:603.59Ref: TM-T10297L
1mg52,00€5mg103,00€10mg148,00€25mg235,00€50mg334,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)138,00€Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1CXCR4 antagonist 2
CAS:CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Fórmula:C25H36N6Cor e Forma:SolidPeso molecular:420.605CXCL-CXCR1/2-IN-1
CAS:CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Fórmula:C14H8Cl2N4O3SPureza:99.4%Cor e Forma:SoildPeso molecular:383.21ITIC-4F
CAS:ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Fórmula:C94H78F4N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1499.92Bam 12P
CAS:Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Fórmula:C62H97N21O16SPureza:98%Cor e Forma:SolidPeso molecular:1424.64Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42Vimnerixin
CAS:Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Fórmula:C19H25FN4O5S2Cor e Forma:SolidPeso molecular:472.55ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Fórmula:C94H82N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1427.96KRH-3955 hydrochloride
CAS:KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Fórmula:C28H48Cl3N7Cor e Forma:SolidPeso molecular:589.09VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Cor e Forma:Odour SolidCTCE-9908
CAS:CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Fórmula:C86H147N27O23Pureza:98%Cor e Forma:SolidPeso molecular:1927.27TC14012
CAS:CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Fórmula:C90H140N34O19S2Pureza:98%Cor e Forma:SolidPeso molecular:2066.43PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Cor e Forma:Odour Solid
