CXCR
Os CXCRs são uma subclasse de GPCRs que se ligam a quimiocinas, pequenas proteínas sinalizadoras que guiam o movimento de células imunológicas em direção a locais de inflamação, infecção ou lesão. Os CXCRs desempenham papéis cruciais nas respostas imunológicas, metástase do câncer e doenças inflamatórias. Moduladores de CXCRs estão sendo investigados por seu potencial no tratamento de doenças autoimunes, câncer e condições inflamatórias crônicas. Na CymitQuimica, oferecemos uma gama de moduladores de CXCRs de alta qualidade para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 188 produtos para "CXCR".
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Delmetacin
CAS:Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Fórmula:C18H15NO3Pureza:99.91%Cor e Forma:SolidPeso molecular:293.3166Motixafortide TFA
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Fórmula:C99H145F4N33O21S2Pureza:>99.99%Cor e Forma:White SolidPeso molecular:2273.54VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Fórmula:C31H39FN2O8Pureza:97.98%Cor e Forma:SolidPeso molecular:586.65Reparixin L-lysine salt
CAS:Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Fórmula:C20H35N3O5SPureza:99%Cor e Forma:White SolidPeso molecular:429.574Quetmolimab
CAS:Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.Pureza:SDS-PAGE:95% SEC-HPLC:97.59%Cor e Forma:Transparent LiquidPeso molecular:~150 kDaEldelumab
CAS:Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.Pureza:95%Cor e Forma:Transparent LiquidPeso molecular:146.64 kDa (Predicted)AMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Fórmula:C32H28F3N5O4Pureza:99.82% - 99.89%Cor e Forma:SolidPeso molecular:603.59LY2510924 acetate
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Fórmula:C64H91N13O13Pureza:97.32%Cor e Forma:SolidPeso molecular:1250.49Vimnerixin
CAS:Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Fórmula:C19H25FN4O5S2Pureza:99.52%Cor e Forma:White SolidPeso molecular:472.554ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Fórmula:C94H82N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1427.942Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Fórmula:C62H88N14O10Cor e Forma:SolidPeso molecular:1189.45Plerixafor-D4
CAS:Plerixafor-D4 is the deuterated form of Plerixafor. Plerixafor (T1776) (AMD 3100) acts as a selective CXCR4 antagonist with an IC50 of 44 nM. It serves as an immunostimulant and a hematopoietic stem cell mobilizer, and it also functions as an allosteric agonist of CXCR7. Plerixafor (T1776) inhibits the replication of HIV-1 and HIV-2 with an EC50 of 1-10 nM.Fórmula:C28H54N8Peso molecular:506.81VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Cor e Forma:Odour SolidCXCR4 antagonist 2
CAS:CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Fórmula:C25H36N6Cor e Forma:SolidPeso molecular:420.605ITIC-4F
CAS:ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Fórmula:C94H78F4N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1499.90KRH-3955 hydrochloride
CAS:KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Fórmula:C28H48Cl3N7Cor e Forma:SolidPeso molecular:589.09LN6023 hydrochloride
LN6023 (hydrochloride) (Compound 27) acts as a CXCR7 agonist. It can stimulate the recruitment of β-arrestin in HEK293T cells expressing human CXCR7, with an EC50 of 3.5 µM. Additionally, LN6023 (hydrochloride) reduces surface levels of P-selectin in isolated and washed human platelets and is applicable in studies of platelet-mediated thrombosis.CTCE-9908
CAS:CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Fórmula:C86H147N27O23Pureza:98%Cor e Forma:SolidPeso molecular:1927.27CXCR7 modulator 1
CAS:CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Fórmula:C48H57F2N7O7SPureza:98%Cor e Forma:SolidPeso molecular:914.071
