TGF-beta/Smad
Os inibidores da via TGF-beta/Smad são compostos que interferem na via de sinalização do TGF-beta (Transforming Growth Factor-beta), mediada por proteínas Smad. Esta via está envolvida na regulação do crescimento celular, diferenciação, apoptose e função das células-tronco. A desregulação da sinalização TGF-beta/Smad está associada ao câncer, fibrose e outras doenças. Os inibidores desta via são ferramentas importantes para estudar estas condições e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores de TGF-beta/Smad para apoiar sua pesquisa em sinalização celular, oncologia e reparação de tecidos.
Foram encontrados 70 produtos para "TGF-beta/Smad".
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Sotatercept
CAS:Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Pureza:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:38.94 kDaBintrafusp alfa
CAS:Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.Pureza:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:177.25 kDaSRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Cor e Forma:SolidPeso molecular:329.48SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Cor e Forma:SolidPeso molecular:365.94Ref: TM-T5129
1mg34,00€2mg44,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg105,00€25mg215,00€50mg334,00€100mg497,00€200mg755,00€Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Fórmula:C48H78O19Pureza:98% - 99.96%Cor e Forma:Red SolidPeso molecular:959.12Chebulinic acid
CAS:Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Fórmula:C41H32O27Pureza:98.91% - 99.71%Cor e Forma:SolidPeso molecular:956.68Ref: TM-TQ0184
1mg66,00€5mg145,00€10mg203,00€1mL*10mM (DMSO)215,00€25mg409,00€50mg595,00€100mg833,00€(E)-SIS3
CAS:(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Fórmula:C28H27N3O3·HClPureza:95.64% - 98%Cor e Forma:Yellow SolidPeso molecular:489.99Ref: TM-T3636
1mg40,00€2mg54,00€5mg105,00€1mL*10mM (DMSO)114,00€10mg164,00€25mg326,00€50mg485,00€100mg692,00€500mg1.395,00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Cor e Forma:SolidPeso molecular:363.39Ref: TM-T16708
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Fórmula:C16H15FN2O4Pureza:99.66%Cor e Forma:SolidPeso molecular:318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€1mL*10mM (DMSO)71,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Cor e Forma:SolidPeso molecular:686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€1mL*10mM (DMSO)93,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 98.85%Cor e Forma:White SolidPeso molecular:317.34ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Cor e Forma:Yellow SolidPeso molecular:415.52Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Cor e Forma:White SolidPeso molecular:369.42Ref: TM-T2510
5mg46,00€10mg52,00€1mL*10mM (DMSO)52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1g657,00€Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Fórmula:C15H20O2Pureza:99.02% - 99.66%Cor e Forma:SolidPeso molecular:232.32BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Fórmula:C14H10BrNOSPureza:99.48% - 99.80%Cor e Forma:SolidPeso molecular:320.2Ref: TM-T7799
5mg44,00€1mL*10mM (DMSO)48,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Fórmula:C18H12ClFN6OPureza:97.67%Cor e Forma:SolidPeso molecular:382.78BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Cor e Forma:SolidPeso molecular:287.32Ref: TM-T8330
1mg48,00€5mg96,00€1mL*10mM (DMSO)131,00€10mg133,00€25mg259,00€50mg371,00€100mg527,00€200mg713,00€Trimethylamine N-oxide dihydrate
CAS:TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.Fórmula:C3H13NO3Pureza:98.75% - 99.97%Cor e Forma:White CrystalPeso molecular:111.14LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Cor e Forma:SolidPeso molecular:435.52SD-208
CAS:SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Cor e Forma:SolidPeso molecular:352.75
