TGF-beta/Smad
Os inibidores da via TGF-beta/Smad são compostos que interferem na via de sinalização do TGF-beta (Transforming Growth Factor-beta), mediada por proteínas Smad. Esta via está envolvida na regulação do crescimento celular, diferenciação, apoptose e função das células-tronco. A desregulação da sinalização TGF-beta/Smad está associada ao câncer, fibrose e outras doenças. Os inibidores desta via são ferramentas importantes para estudar estas condições e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores de TGF-beta/Smad para apoiar sua pesquisa em sinalização celular, oncologia e reparação de tecidos.
Foram encontrados 70 produtos para "TGF-beta/Smad".
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Livmoniplimab
CAS:Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32Pureza:95%Cor e Forma:Transparent LiquidPeso molecular:~150 kDaGinisortamab
CAS:Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Pureza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:147.55 kDaNisevokitug
CAS:Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.Pureza:95%Cor e Forma:LiquidPeso molecular:143.51 kDaMetelimumab
CAS:Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Pureza:95%Cor e Forma:Transparent LiquidPeso molecular:~150 kDaAnti-Mouse/Human/Rat/Monkey/Hamster/Canine TGFβ Antibody (1D11.16.8)
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) is an IgG antibody inhibitor targeting TGF-β in multiple species including mouse, human, rabbit, monkey, hamster, dog, and cow. For information on the isotype control, refer to Mouse IgG1 kappa, Isotype Control.Cor e Forma:Odour LiquidTrevogrumab
CAS:Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.02 kDaRilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:SoildEmugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidHalofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Fórmula:C16H17BrClN3O3Pureza:99.53%Cor e Forma:Yellow SolidPeso molecular:414.68Ref: TM-T6856
1mg34,00€5mg82,00€1mL*10mM (DMSO)92,00€10mg116,00€25mg227,00€50mg344,00€100mg517,00€500mg1.134,00€Chromenone 1
CAS:Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Fórmula:C18H10F3N3O2Pureza:99.81% - 99.83%Cor e Forma:SolidPeso molecular:357.29Ref: TM-T61301
1mg50,00€5mg105,00€1mL*10mM (DMSO)107,00€10mg154,00€25mg224,00€50mg314,00€100mg427,00€200mg575,00€(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Fórmula:C28H27N3O3Pureza:98%Cor e Forma:SolidPeso molecular:453.53TGFβRI-IN-1
CAS:TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Fórmula:C20H14D3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:362.4DMH2
CAS:DMH2 is a selective BMP type I receptor (ALK2/ALK3) inhibitor. DMH2 inhibits the proliferation of lung cancer cell lines and induces cell death.Fórmula:C27H25N5O2Pureza:99.85%Cor e Forma:SolidPeso molecular:451.52PF-06952229
CAS:PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Fórmula:C23H24ClFN4O3Pureza:99.73% - 99.73%Cor e Forma:SolidPeso molecular:458.91Ref: TM-T12433
1mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mL*10mM (DMSO)A consultar200mgA consultarHalofuginone hydrobromide
CAS:Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Cor e Forma:SolidPeso molecular:495.59Ref: TM-T3524
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)84,00€10mg106,00€25mg207,00€50mg310,00€100mg469,00€500mg897,00€CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Fórmula:C30H33N3Pureza:99.51%Cor e Forma:SolidPeso molecular:435.6Ref: TM-T62483
2mg34,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg156,00€50mg245,00€100mg371,00€200mg523,00€LY2382770
LY2382770 is a human monoclonal antibody (mAb) that specifically targets TGFB1. It is utilized in the study of diabetic nephropathy.SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Fórmula:C14H14ClFN2O2Pureza:99.94%Cor e Forma:White SolidPeso molecular:296.72Ref: TM-T60644
1mg49,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg141,00€25mg268,00€50mg520,00€100mg750,00€500mg1.521,00€TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582TGFβ-IN-5
CAS:TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Fórmula:C20H16N4Pureza:99.55% - 99.62%Cor e Forma:SolidPeso molecular:312.37
