Receptor IL

Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia …

Sugiol (10-Deoxoxanthoperol) has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, …

Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, …

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to …

Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct …

YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of …

Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid …

Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally …

BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and …

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 …

2-Benzothiazolamine (2-ABT) is a nitrogen-containing heterocyclic compound used as a reaction intermediate in the synthesis …

Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic …

Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.

Bornyl acetate (Isobornyl acetate) has an anti-inflammatory effect. It is the volatile ingredient in some …

IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent …

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory …

Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory …

Diacerein (Fisiodar) is a prodrug which is metabolized to rhein. It is currently approved in …

Sarilumab (anti-IL-6Rα) is a useful organic compound for research related to life sciences and the …

Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via …

Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic …

Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) is isolated from the roots of Cayaponia tayuya with anti-cancer activity.

Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity …

Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced …

MyD88-IN-1 is a potent MyD88 inhibitor MyD88-IN-1 has anti-inflammatory activity and inhibits downstream inflammatory signaling …

Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly …

Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. …

(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with …

Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Luteolin-4'-O-glucoside (Luteolin-4-o-glucoside) is an inhibitor of IL-5 (IC50 = 3.7 μM) with anti-complementary, antioxidant and …

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …

Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly …

Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation …

Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological …

Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody …

EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain …

Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of …

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen …

NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the …

JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical …

Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food …

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen …

Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can …

Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the …

Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 …

Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and …

Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of …

Nosantine racemate is the racemate of Nosantine which is a IL-2 inducer or enhancer of …

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it …

Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial …

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects …

1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic …

Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in …

Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and …

Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced …

Abrezekimab (VR 942) is composed of CDP7766, leucine, and trehalose. Abrezekimab is a humanized antibody …

Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab …

Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic …

3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.

Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated …

(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated …

Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.

Hydrangenol 8-O-glucoside may have anti-inflammary activity.

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and …

Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.