STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Foram encontrados 102 produtos para "STAT".
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STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Cor e Forma:Odour SolidSTAT3-IN-39
CAS:STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Fórmula:C20H17F3N2O3SCor e Forma:SolidPeso molecular:422.42(R)-Lisofylline
CAS:(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Fórmula:C13H20N4O3Pureza:99.50% - 99.85%Cor e Forma:White SolidPeso molecular:280.32STAT3-IN-28
STAT3-IN-28 (compound 18) is an inhibitor of STAT3. It can suppress the activation of microglia and exhibits anti-neuroinflammatory effects. Additionally, STAT3-IN-28 is capable of crossing the blood-brain barrier.Fórmula:C20H23N3O2Cor e Forma:SolidPeso molecular:337.17903STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Fórmula:C25H27N5OCor e Forma:SolidPeso molecular:413.51Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Fórmula:C30H26N2O2Cor e Forma:SolidPeso molecular:446.54STAT3-IN-41
STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.Fórmula:C22H30F3NO7Cor e Forma:SolidPeso molecular:477.471MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Fórmula:C15H12N2O2Pureza:99.74%Cor e Forma:SolidPeso molecular:252.27STAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Fórmula:C36H61N8O12PCor e Forma:SolidPeso molecular:828.89Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Fórmula:C26H24N2O11P2Pureza:97.18%Cor e Forma:SolidPeso molecular:602.42Balsalazide
CAS:Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Fórmula:C17H15N3O6Pureza:99.31%Cor e Forma:Orange SolidPeso molecular:357.32Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Cor e Forma:White SolidPeso molecular:230.30Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Fórmula:C42H68O13Pureza:98.34% - 99.73%Cor e Forma:White SolidPeso molecular:780.981-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Fórmula:C21H13ClF3N3O2Pureza:97.56%Cor e Forma:SolidPeso molecular:431.8Ref: TM-T22424
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)94,00€10mg120,00€25mg250,00€50mg409,00€100mg590,00€200mg827,00€HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Fórmula:C15H14Cl3N3O4Pureza:99.01% - 99.06%Cor e Forma:SolidPeso molecular:406.64TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFórmula:C12H10FN3O2SPureza:95.03% - 97.86%Cor e Forma:SolidPeso molecular:279.29BP-1-102
CAS:BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Fórmula:C29H27F5N2O6SPureza:99.25% - 99.44%Cor e Forma:White SolidPeso molecular:626.59Ref: TM-T3708
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)99,00€10mg113,00€25mg200,00€50mg334,00€100mg495,00€AS1810722
CAS:AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Fórmula:C25H25F2N7OPureza:99.13%Cor e Forma:SolidPeso molecular:477.512-(1,8-naphthyridin-2-yl)phenol
CAS:2-NP is a STAT1 enhancer.Fórmula:C14H10N2OPureza:99.82% - 99.94%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T2168
5mg57,00€1mL*10mM (DMSO)63,00€10mg90,00€25mg177,00€50mg281,00€100mg444,00€200mg647,00€500mg982,00€Balsalazide disodium dihydrate
CAS:Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.Fórmula:C17H17N3Na2O8Pureza:98.95% - 99.49%Cor e Forma:SolidPeso molecular:437.31
