STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Foram encontrados 109 produtos para "STAT".
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HO-3867
CAS:HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.Fórmula:C28H30F2N2O2Pureza:91.18% - 99.21%Cor e Forma:SolidPeso molecular:464.5468S3I-201
CAS:S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Fórmula:C16H15NO7SPureza:97.83%Cor e Forma:SolidPeso molecular:365.36Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Fórmula:C25H24O6Pureza:98.68% - 99.8%Cor e Forma:Yellow SolidPeso molecular:420.4545STAT5-IN-1
CAS:STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Fórmula:C16H11N3O3Pureza:99.92% - ≥95%Cor e Forma:White SolidPeso molecular:293.2768Balsalazide disodium dihydrate
CAS:Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.Fórmula:C17H17N3Na2O8Pureza:98.95% - 99.71%Cor e Forma:SolidPeso molecular:437.31Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Fórmula:C14H8O4Pureza:98.43% - 99.85%Cor e Forma:SolidPeso molecular:240.21Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Cor e Forma:White SolidPeso molecular:332.3909RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Fórmula:C14H5F6N5OPureza:98.15% - 98.85%Cor e Forma:Yellow SolidPeso molecular:373.2128Garcinone D
CAS:Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).Fórmula:C24H28O7Pureza:99.94% - 99.96%Cor e Forma:White SolidPeso molecular:428.4749Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.Fórmula:C20H18O6Pureza:99.81%Cor e Forma:Off White PowderPeso molecular:354.3533ZDZ-553
ZDZ-553 is an orally active STAT1 inhibitor with an IC50 value of 0.87 μM. It modulates the STAT1 signaling pathway, influencing downstream lipid metabolism and inflammatory pathways. In mouse models of non-alcoholic steatohepatitis (NASH), ZDZ-553 reduces liver steatosis and decreases inflammatory responses. ZDZ-553 also has distinct safety features and is suitable for research related to NASH.NTZ-24
CAS:NTZ-24 is a selective STAT3 inhibitor for cervical cancer and oncogenic signaling pathway research.Fórmula:C10H5Cl2N3O3SPureza:99.50%Cor e Forma:SolidPeso molecular:318.14STAT3-IN-39
CAS:STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Fórmula:C20H17F3N2O3SCor e Forma:SolidPeso molecular:422.42inS3-54-A26
CAS:inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Fórmula:C25H19ClN2O2Pureza:99.57%Cor e Forma:SolidPeso molecular:414.884MMPP
CAS:MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.Fórmula:C17H18O3Pureza:98.87% - 99.83%Cor e Forma:White SolidPeso molecular:270.32SBT-100
SBT-100 is a human monoclonal antibody (mAb) that targets STAT3. It inhibits IL-6-mediated nuclear translocation of P-STAT3 in HEp-2 and PANC-1 cells and demonstrates tumor growth inhibition in MDA-MB-231.Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Fórmula:C28H26N2O12P2Pureza:98.48%Cor e Forma:White SolidPeso molecular:644.46STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFórmula:C30H27F4N7SPureza:98%Cor e Forma:SolidPeso molecular:593.64STAT3-IN-B9
CAS:STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Fórmula:C20H13NO5SPureza:98.19%Cor e Forma:Yellow SolidPeso molecular:379.386inS3-54A18
CAS:inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Fórmula:C23H16ClNO2Pureza:99.68%Cor e Forma:SolidPeso molecular:373.832
