Pim
As quinases Pim são uma família de quinases serina/treonina que desempenham um papel fundamental na sobrevivência celular, proliferação e apoptose. Estas quinases são efetores a jusante na via de sinalização JAK/STAT e estão envolvidas em vários processos fisiológicos, incluindo respostas imunológicas e hematopoiese. A superexpressão das quinases Pim tem sido associada ao desenvolvimento de câncer, tornando-as alvos importantes para a intervenção terapêutica. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de quinases Pim de alta qualidade para apoiar sua pesquisa em oncologia, biologia celular e transdução de sinal.
Foram encontrados 32 produtos de "Pim"
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Uzansertib phosphate
CAS:<p>Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.</p>Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Cor e Forma:SolidPeso molecular:611.51Pim-1 kinase inhibitor 8
CAS:<p>Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.</p>Fórmula:C14H17N3O3Pureza:99.81%Cor e Forma:SoildPeso molecular:275.3R8-T198wt
CAS:<p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>Fórmula:C111H211N59O26SPureza:98%Cor e Forma:SolidPeso molecular:2820.33Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Cor e Forma:Odour SolidVB1080
<p>VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.</p>Fórmula:C27H27N3O3Cor e Forma:SolidPeso molecular:441.522Pim-1/2 kinase inhibitor 1
CAS:<p>Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.</p>Fórmula:C11H9NO3SPureza:99.78%Cor e Forma:SolidPeso molecular:235.26HJ-PI01
CAS:<p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>Fórmula:C14H11NO2Pureza:98.92%Cor e Forma:SolidPeso molecular:225.24AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Cor e Forma:SolidPeso molecular:379.48(Z)-SMI-4a
CAS:<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Cor e Forma:SolidPeso molecular:273.23TCS-PIM-1-4a
CAS:<p>SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).</p>Fórmula:C11H6F3NO2SPureza:99.89%Cor e Forma:SolidPeso molecular:273.23SMI-16a
CAS:<p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:SolidPeso molecular:263.31Quercetagetin
CAS:<p>Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.</p>Fórmula:C15H10O8Pureza:99.65% - 99.91%Cor e Forma:SolidPeso molecular:318.24Hispidulin
CAS:<p>Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).</p>Fórmula:C16H12O6Pureza:98.53% - 99.87%Cor e Forma:SolidPeso molecular:300.26SGI-1776
CAS:<p>SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.</p>Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Cor e Forma:SolidPeso molecular:405.42Pim1/AKK1-IN-1
CAS:<p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>Fórmula:C20H13N5OPureza:97.03% - 98.69%Cor e Forma:SolidPeso molecular:339.35TCS PIM-1 1
CAS:<p>TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.</p>Fórmula:C18H11BrN2O2Pureza:97% - 97.98%Cor e Forma:SolidPeso molecular:367.2TP-3654
CAS:<p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>Fórmula:C22H25F3N4OPureza:99.8% - 99.95%Cor e Forma:SolidPeso molecular:418.46CX-6258 hydrochloride
CAS:<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Fórmula:C26H24ClN3O3·HClPureza:96.03% - 98.60%Cor e Forma:SolidPeso molecular:498.4K00135
CAS:<p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>Fórmula:C18H18N4OPureza:98.16%Cor e Forma:SolidPeso molecular:306.36CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Fórmula:C26H24ClN3O3Pureza:97.46%Cor e Forma:SolidPeso molecular:461.94AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46M-110
CAS:<p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>Fórmula:C22H28ClN5O3Pureza:99.55%Cor e Forma:SolidPeso molecular:445.94PIM-1 Inhibitor 2
CAS:<p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75FD1024
CAS:<p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>Fórmula:C21H20F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:430.47GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Fórmula:C22H24N8OPureza:98%Cor e Forma:SolidPeso molecular:416.48PIM1-IN-4
CAS:<p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>Fórmula:C27H25BrCl2CuN6OPureza:98%Cor e Forma:SolidPeso molecular:663.88Pim-1 kinase inhibitor 5
CAS:<p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26PIM1-IN-1
CAS:<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Fórmula:C25H30N8O2Pureza:98%Cor e Forma:SolidPeso molecular:474.56PIM-IN-2
CAS:<p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>Fórmula:C19H22N4O2Pureza:98%Cor e Forma:SolidPeso molecular:338.4HS94
CAS:<p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>Fórmula:C15H15N5O2SPureza:95.04%Cor e Forma:SolidPeso molecular:329.38GDC-0339
CAS:<p>GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.</p>Fórmula:C20H22F3N7OSCor e Forma:SolidPeso molecular:465.5Pim-1 kinase inhibitor 6
CAS:<p>Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].</p>Fórmula:C21H10BrCl2N3Cor e Forma:SolidPeso molecular:455.13
