MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 891 produtos de "MAPK"
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(aS)-PH-797804
CAS:(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].Fórmula:C22H19BrF2N2O3Cor e Forma:SolidPeso molecular:477.3KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Fórmula:C31H38N6O3Pureza:98%Cor e Forma:SolidPeso molecular:542.67TNIK&MAP4K4-IN-1
CAS:TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in humanFórmula:C25H23FN4O3Cor e Forma:SolidPeso molecular:446.47KRAS G12C inhibitor 34
CAS:KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.Fórmula:C32H32ClN5O3Cor e Forma:SolidPeso molecular:570.08KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Fórmula:C32H37N7O2Pureza:98%Cor e Forma:SolidPeso molecular:551.68pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Fórmula:C36H34F2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:636.69JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Fórmula:C26H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:467.52MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Fórmula:C18H22FN3O5SPureza:98%Cor e Forma:SolidPeso molecular:411.45MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFórmula:C18H20FN3O4SPureza:98%Cor e Forma:SolidPeso molecular:393.43SKF-86002 dihydrochloride
CAS:p38 MAP kinase inhibitorFórmula:C16H14Cl2FN3SPureza:98%Cor e Forma:SolidPeso molecular:370.27K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Fórmula:C22H23Cl2N3O3Cor e Forma:SolidPeso molecular:448.34pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:587.63SB 203580 sulfone
CAS:SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].Fórmula:C21H16FN3O2SCor e Forma:SolidPeso molecular:393.43AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Fórmula:C25H28FN7O2Cor e Forma:SolidPeso molecular:477.53HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Fórmula:C30H32N8O3SCor e Forma:SolidPeso molecular:584.69Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45BI-0474
CAS:BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.Fórmula:C30H37N9O2SPureza:99.96%Cor e Forma:SolidPeso molecular:587.74AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Fórmula:C29H29Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:534.48KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Fórmula:C32H39F6N7O5Pureza:98%Cor e Forma:SolidPeso molecular:715.69(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Fórmula:C24H20Cl2FN5O2Pureza:98.73%Cor e Forma:SolidPeso molecular:500.35
