MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 890 produtos de "MAPK"
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KRAS inhibitor-25
CAS:KRAS inhibitor-25 (compound 151a), a pyrido[2,3-d]pyrimidine derivative, effectively inhibits KRas G12V, KRas WT, and KRas G12R with IC50 values all below 100 nM.
Fórmula:C32H38ClF2N5O3Cor e Forma:SolidPeso molecular:614.13SIAIS562055
SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.Fórmula:C49H62F3N7O5SCor e Forma:SolidPeso molecular:918.12MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Fórmula:C13H10FN3O2SCor e Forma:SolidPeso molecular:291.3KRpep-2d TFA
KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset forFórmula:C110H183F3N44O27S2Cor e Forma:SolidPeso molecular:2675.03Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Cor e Forma:SolidPROTAC K-Ras Degrader-4
CAS:PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.Fórmula:C50H60N12O6S2Pureza:99.30%Cor e Forma:SoildPeso molecular:989.22KRAS G12D inhibitor 7
CAS:KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.Fórmula:C32H38N8O3Cor e Forma:SolidPeso molecular:582.709Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.
Fórmula:C55H95N19O13Pureza:96.63%Cor e Forma:SolidPeso molecular:1230.46Edaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Fórmula:C26H27N7O2Cor e Forma:SolidPeso molecular:469.549JIP-1(153-163)
CAS:Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Fórmula:C61H104N20O14Pureza:98%Cor e Forma:SolidPeso molecular:1341.6HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Cor e Forma:Odour SolidR 115777
CAS:R 115777 is an inhibitor of farnesyl transferase.
Fórmula:C27H22Cl2N4OPureza:98%Cor e Forma:SolidPeso molecular:489.40YARA peptide
YARA peptide is a cell-penetrating peptide that acts as an MK2 inhibitor. In vitro skin culture models demonstrate that nanoparticles loaded with YARA reduce levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α). YARA peptide holds potential for research in atopic dermatitis (AD).Fórmula:C99H172N38O27Cor e Forma:SolidPeso molecular:2326.66RP03707
CAS:RP03707 is a PROTAC degrader of KRASG12D.Fórmula:C55H58F3N11O4Cor e Forma:SolidPeso molecular:994.12NEK7-IN-2
NEK7-IN-2 (compound 23) is a potent inhibitor of the NLRP3-NEK7 interaction. It enhances the thermal stability of NEK7 and modulates the assembly of the NLRP3 inflammasome. Additionally, NEK7-IN-2 inhibits the release of IL-1β.Fórmula:C27H28F4N6O2Cor e Forma:SolidPeso molecular:544.54MRT-3486
MRT-3486 (Compound 5) is a cereblon-based molecular glue degrader for NEK7. It is suitable for research on autoinflammatory diseases.Cor e Forma:Odour SolidMLKL-IN-2
CAS:MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
Fórmula:C26H25N5OPureza:98.30%Cor e Forma:SolidPeso molecular:423.51JNK3 inhibitor-7
Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.Fórmula:C32H31N7O3Cor e Forma:SolidPeso molecular:561.63MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Cor e Forma:Odour SolidMHJ-627
MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leadingFórmula:C34H45BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:609.64
