MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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2-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.Fórmula:C17H16O5Pureza:98.68%Cor e Forma:SolidPeso molecular:300.31Ref: TM-T50064
1mg86,00€2mg114,00€5mg170,00€10mg255,00€25mg437,00€50mg640,00€100mg910,00€500mg1.833,00€1mL*10mM (DMSO)170,00€Cefotetan
CAS:Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.Fórmula:C17H17N7O8S4Pureza:95.72% - 99.38%Cor e Forma:SolidPeso molecular:575.62RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Cor e Forma:SolidPeso molecular:542.55Ref: TM-T3711
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg259,00€50mg424,00€100mg625,00€500mg1.311,00€1mL*10mM (DMSO)94,00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Fórmula:C16H17FIN3O4Pureza:98.72%Cor e Forma:SolidPeso molecular:461.23NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Fórmula:C29H30F3N5O2Pureza:98.32% - ≥95%Cor e Forma:SolidPeso molecular:537.58BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Ref: TM-T6789
1mg82,00€2mg114,00€5mg200,00€10mg284,00€25mg477,00€50mg692,00€100mg973,00€1mL*10mM (DMSO)200,00€XMD17-109
CAS:XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Cor e Forma:SolidPeso molecular:638.8Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Fórmula:C8H10NO6PPureza:97.52%Cor e Forma:SolidPeso molecular:247.14GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Cor e Forma:SolidPeso molecular:417.48ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.85CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Fórmula:C16H27N5O2Pureza:99.96%Cor e Forma:SolidPeso molecular:321.42IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Cor e Forma:SolidPeso molecular:560.594Ref: TM-T22258
2mg37,00€5mg52,00€10mg85,00€25mg156,00€50mg274,00€100mg426,00€500mg938,00€1mL*10mM (DMSO)77,00€L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Fórmula:C20H14ClN3OPureza:≥95%Cor e Forma:SolidPeso molecular:347.8ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Cor e Forma:SolidPeso molecular:405.41Ref: TM-T9697
1mg90,00€5mg215,00€10mg321,00€25mg582,00€50mg873,00€100mg1.216,00€1mL*10mM (DMSO)236,00€PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Cor e Forma:SolidPeso molecular:413.83Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Cor e Forma:SolidPeso molecular:453.56Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Fórmula:C14H15NO3Pureza:97.13%Cor e Forma:SolidPeso molecular:245.27K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58Ref: TM-T5418
1mg50,00€5mg105,00€10mg177,00€25mg321,00€50mg482,00€100mg710,00€200mg982,00€1mL*10mM (DMSO)116,00€
