MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Fórmula:C14H15NO3Pureza:97.13%Cor e Forma:SolidPeso molecular:245.27K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58Ref: TM-T5418
1mg50,00€5mg105,00€10mg177,00€25mg321,00€50mg482,00€100mg710,00€200mg982,00€1mL*10mM (DMSO)116,00€Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Fórmula:C15H8Br2ClNO2Pureza:98.53%Cor e Forma:SolidPeso molecular:429.49Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Fórmula:C23H20F3N5O2S2Pureza:99.62% - >99.99%Cor e Forma:SolidPeso molecular:519.56ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Cor e Forma:SolidPeso molecular:473.93Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Fórmula:C8H10NO6PPureza:97.52%Cor e Forma:SolidPeso molecular:247.14GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Cor e Forma:SolidPeso molecular:417.48CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Cor e Forma:SolidPeso molecular:424.93BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Cor e Forma:SolidPeso molecular:379.37Sotorasib
CAS:Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:560.594Ref: TM-T8684
1g1.359,00€1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg225,00€50mg374,00€100mg459,00€500mg1.026,00€1mL*10mM (DMSO)87,00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Fórmula:C16H27N5O2Pureza:99.96%Cor e Forma:SolidPeso molecular:321.42Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Cor e Forma:SolidPeso molecular:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€1mL*10mM (DMSO)112,00€PF-06260933 HCl
CAS:PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.Fórmula:C16H15Cl3N4Cor e Forma:SolidPeso molecular:369.68SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Fórmula:C24H28N2O9SPureza:95.65%Cor e Forma:SolidPeso molecular:520.55CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39Ref: TM-T5393
1mg47,00€2mg62,00€5mg92,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€1mL*10mM (DMSO)101,00€Compound 3344 hydrochloride
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H27ClN2O3Pureza:99.23%Cor e Forma:SolidPeso molecular:426.94Ref: TM-T9184L
1mg136,00€5mg269,00€10mg404,00€25mg665,00€50mg888,00€100mg1.243,00€1mL*10mM (DMSO)318,00€p-Cresyl sulfate potassium
CAS:p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanineFórmula:C7H7KO4SPureza:99.38% - 99.90%Cor e Forma:SolidPeso molecular:226.29BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Ref: TM-T6789
1mg82,00€2mg114,00€5mg200,00€10mg284,00€25mg477,00€50mg692,00€100mg973,00€1mL*10mM (DMSO)200,00€
