MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 922 produtos para "MAPK".
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AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Cor e Forma:SolidPeso molecular:648.776ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Cor e Forma:SolidPeso molecular:430.84ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Cor e Forma:SolidPeso molecular:408.4519SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Fórmula:C5H3N5O2S3Pureza:98.39%Cor e Forma:SolidPeso molecular:261.3MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Cor e Forma:SolidPeso molecular:388.4656Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 99.12%Cor e Forma:White SolidPeso molecular:462.89CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Cor e Forma:SolidPeso molecular:458.4363PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Cor e Forma:SolidPeso molecular:374.46BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.4648LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Cor e Forma:Yellow SolidPeso molecular:528.488BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Fórmula:C19H16N2O4Pureza:99.78%Cor e Forma:SolidPeso molecular:336.3413HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Fórmula:C23H26N6O3Pureza:97.06%Cor e Forma:Yellow SolidPeso molecular:434.4909ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Fórmula:C36H43N7O3Cor e Forma:SolidPeso molecular:621.34274JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Fórmula:C120H213F3N48O28Pureza:98%Cor e Forma:SolidPeso molecular:2833.28BChE/p38-α MAPK-IN-2
BChE/p38-α MAPK-IN-2 is a dual inhibitor of BChE and p38-α MAPK. It has an IC50 of 5.1 nM for hBChE and exhibits a 1000-fold selectivity over hAChE. Its IC50 for p38α MAPK is 8.12 μM. BChE/p38-α MAPK-IN-2 demonstrates neuroprotective properties, making it useful for research on neurological disorders such as Alzheimer's disease.Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Cor e Forma:SolidPeso molecular:319.38Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 Free Base is a highly potent RAS GTPase inhibitor with antitumor activity.Fórmula:C25H27ClFN5Cor e Forma:White SolidPeso molecular:451.97MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Cor e Forma:Odour SolidHRS 4642
CAS:HRS 4642 is a selective KRAS G12D inhibitor with a Kd value of 0.083 nM, antitumour, inhibits phosphorylation of downstream MEK and ERK proteins.Fórmula:C34H35F3N6O3Pureza:99.17%Peso molecular:632.68
