MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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SB 204900
CAS:SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.Fórmula:C18H17NO2Cor e Forma:SolidPeso molecular:279.33HPK1-IN-29
CAS:"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Fórmula:C26H18F3N5O2Cor e Forma:SolidPeso molecular:489.45DDO3711
CAS:"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Fórmula:C42H41N9O6Cor e Forma:SolidPeso molecular:767.83KRAS G12C inhibitor 29
CAS:KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Fórmula:C23H21ClFN5O2Cor e Forma:SolidPeso molecular:453.9Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Cor e Forma:SolidPeso molecular:326.358-CPT-2Me-cAMP, sodium salt
CAS:8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.Fórmula:C17H16ClN5NaO6PSCor e Forma:SolidPeso molecular:507.82SCH-53870
CAS:SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.Fórmula:C18H18N2O4SCor e Forma:SolidPeso molecular:358.41KRAS inhibitor-16
CAS:KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.Fórmula:C20H16Cl2FN3O2SCor e Forma:SolidPeso molecular:452.33SOS1-IN-12
CAS:SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).Fórmula:C23H26F3N5Cor e Forma:SolidPeso molecular:429.48MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Fórmula:C14H11NO2S2Cor e Forma:SolidPeso molecular:289.37ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Fórmula:C28H31ClF2N6O2Cor e Forma:SolidPeso molecular:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Fórmula:C16H11Cl2FN4O2Cor e Forma:SolidPeso molecular:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Fórmula:C20H17Cl2FN4OSCor e Forma:SolidPeso molecular:451.34(S)-p38 MAPK Inhibitor III
CAS:(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.Fórmula:C23H21FN4SCor e Forma:SolidPeso molecular:404.5BMS-214662 hydrochloride
CAS:BMS-214662: a farnesyltransferase inhibitor, nonsedating benzodiazepine, blocks Ras-related tumorigenesis.Fórmula:C25H24ClN5O2S2Cor e Forma:SolidPeso molecular:526.07J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Fórmula:C17H9ClFN3O2SPureza:99.90%Cor e Forma:SolidPeso molecular:373.79(R)-PD 0325901CL
CAS:(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.Fórmula:C16H14ClF2IN2O4Cor e Forma:SolidPeso molecular:498.65RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46RAF-IN-1
CAS:RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.Fórmula:C26H22F3N3O4Cor e Forma:SolidPeso molecular:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Fórmula:C30H39ClN8OPureza:98%Cor e Forma:SolidPeso molecular:563.14
