MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Fórmula:C22H25ClF3N5O3Pureza:97.84%Cor e Forma:SolidPeso molecular:499.91Ref: TM-T38170
1mg87,00€5mg212,00€10mg379,00€25mg780,00€50mg1.206,00€100mg1.795,00€200mg2.422,00€1mL*10mM (DMSO)226,00€SB-682330A
CAS:SB-682330A is a Raf kinase inhibitor.Fórmula:C28H27N3O3Cor e Forma:SolidPeso molecular:453.53pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFórmula:C34H34F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:584.66(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Fórmula:C24H20Cl2FN5O2Pureza:98.73%Cor e Forma:SolidPeso molecular:500.35KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFórmula:C30H36FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:549.64KRAS G12C inhibitor 58
CAS:KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Fórmula:C51H64ClF4N9O8SPureza:98%Cor e Forma:SolidPeso molecular:1074.62KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Fórmula:C24H21ClFN3O3Pureza:97.84%Cor e Forma:SolidPeso molecular:453.89DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Fórmula:C25H23F3N2O5SPureza:98%Cor e Forma:SolidPeso molecular:520.52GNE 220 hydrochloride
CAS:GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Fórmula:C25H27ClN8Cor e Forma:SolidPeso molecular:474.99KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Fórmula:C32H39F6N7O5Pureza:98%Cor e Forma:SolidPeso molecular:715.69B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Fórmula:C19H15N3OSPureza:98%Cor e Forma:SolidPeso molecular:333.41SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Fórmula:C24H26F3N5OPureza:98%Cor e Forma:SolidPeso molecular:457.49BI-0474
CAS:BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.Fórmula:C30H37N9O2SPureza:99.96%Cor e Forma:SolidPeso molecular:587.74Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Fórmula:C30H32N8O3SCor e Forma:SolidPeso molecular:584.69AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Fórmula:C25H28FN7O2Cor e Forma:SolidPeso molecular:477.53SB 203580 sulfone
CAS:SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].Fórmula:C21H16FN3O2SCor e Forma:SolidPeso molecular:393.43pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:587.63HPK1-IN-10
CAS:HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.Fórmula:C31H34N6O2Cor e Forma:SolidPeso molecular:522.64KRAS inhibitor-11
KRAS inhibitor-11 is a KRAS inhibitor .Fórmula:C29H47N9O6Cor e Forma:SolidPeso molecular:617.74
