MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 887 produtos de "MAPK"
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JNK3 inhibitor-2
CAS:JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Fórmula:C20H14N2O2Cor e Forma:SolidPeso molecular:314.34p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Fórmula:C27H33N5O3Cor e Forma:SolidPeso molecular:475.58pan-KRAS-IN-16
CAS:3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H26N2O3Pureza:98%Cor e Forma:SolidPeso molecular:390.47Tpl2 Kinase Inhibitor 1
CAS:Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Fórmula:C21H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:404.83ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Fórmula:C20H16N4O2Pureza:99.71% - 99.95%Cor e Forma:SolidPeso molecular:344.37Ref: TM-T61122
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€UR13870
CAS:UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Fórmula:C24H16F2N4Pureza:99.18% - >99.99%Cor e Forma:SolidPeso molecular:398.41(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Fórmula:C18H24O4Pureza:98.09%Cor e Forma:SolidPeso molecular:304.38Ref: TM-T11137
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)153,00€NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Fórmula:C11H19BrCl2N2Pureza:99.75%Cor e Forma:SolidPeso molecular:330.092Cot inhibitor-1
CAS:Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.Fórmula:C27H27Cl2FN8Pureza:98.87%Cor e Forma:SolidPeso molecular:553.46Ref: TM-T10865
1mg77,00€5mg160,00€10mg235,00€25mg424,00€50mg635,00€100mg935,00€200mg1.283,00€1mL*10mM (DMSO)187,00€BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Fórmula:C31H28N6O2Pureza:97.77%Cor e Forma:SolidPeso molecular:516.59Ref: TM-T10533
1mg110,00€5mg261,00€10mg389,00€25mg643,00€50mg888,00€100mg1.224,00€1mL*10mM (DMSO)298,00€JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Fórmula:C12H11NO3S2Pureza:98.82%Cor e Forma:SolidPeso molecular:281.35GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
Fórmula:C31H28F3N7O3S2Pureza:99.36%Cor e Forma:SolidPeso molecular:667.72Ref: TM-T27454
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Fórmula:C16H19N3OSPureza:99.85%Cor e Forma:SolidPeso molecular:301.41AKP-001
CAS:AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.Fórmula:C21H13ClF2N4O2Pureza:99.50% - 99.92%Cor e Forma:SolidPeso molecular:426.8EO-1606
CAS:EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.Fórmula:C21H17ClFNOPureza:98.28% - 98.84%Cor e Forma:SolidPeso molecular:353.82SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Fórmula:C28H27F3N6O2Pureza:98.32%Cor e Forma:SolidPeso molecular:536.548p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Fórmula:C14H7F6N3OPureza:99.69%Cor e Forma:SolidPeso molecular:347.215p38 MAPK Inhibitor
CAS:p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Fórmula:C20H13ClFN3OPureza:99.91%Cor e Forma:SolidPeso molecular:365.79Ref: TM-T36010
1mg92,00€5mg279,00€10mg434,00€25mg642,00€50mg880,00€100mg1.170,00€200mg1.594,00€500µg56,00€MKK7-COV-9
CAS:MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.Fórmula:C18H16N4O2Pureza:99.73% - 99.83%Cor e Forma:SolidPeso molecular:320.35Ref: TM-T60857
2mg145,00€5mg235,00€10mg376,00€25mg747,00€50mg1.121,00€100mg1.768,00€1mL*10mM (DMSO)259,00€
