MAPK
As MAPKs são uma família de proteínas quinases envolvidas em uma variedade de processos celulares, incluindo crescimento, proliferação, diferenciação e respostas ao estresse. A via de sinalização MAPK consiste em várias camadas, incluindo ERK, JNK e p38 MAPKs, cada uma desempenhando papéis distintos na função celular. A desregulação da sinalização MAPK está ligada ao câncer, doenças inflamatórias e distúrbios metabólicos. Na CymitQuimica, oferecemos uma ampla gama de inibidores e ativadores de MAPK para apoiar sua pesquisa em biologia celular, transdução de sinais e mecanismos de doenças.
Foram encontrados 890 produtos de "MAPK"
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RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Fórmula:C27H28N4O6SCor e Forma:SolidPeso molecular:536.6p38 Kinase inhibitor 4
CAS:Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].Fórmula:C12H9Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:282.13GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Fórmula:C24H21FIN5O3Cor e Forma:SolidPeso molecular:573.36B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Fórmula:C20H19N5O3SPureza:99.31% - 99.78%Cor e Forma:SolidPeso molecular:409.46ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFórmula:C31H32ClN7O3Pureza:98%Cor e Forma:SolidPeso molecular:586.08RAF mutant-IN-1
CAS:RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).Fórmula:C23H18Cl3FN6O2SPureza:98%Cor e Forma:SolidPeso molecular:567.85ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Fórmula:C18H12N6OCor e Forma:SolidPeso molecular:328.33SOS1 agonist-1
CAS:SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].Fórmula:C26H29BrClFN4O2Cor e Forma:SolidPeso molecular:563.89RGB-1
CAS:RGB-1 is a small molecule that stabilizes the RNA G-quadruplex structure and enhances G-quadruplex-mediated RNA translation inhibition.Fórmula:C22H12N4O4S2Pureza:98.07%Cor e Forma:SolidPeso molecular:460.49AZD4747
CAS:AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.Fórmula:C24H22ClFN2O3Pureza:99.36%Cor e Forma:SolidPeso molecular:440.89Ref: TM-T79213
1mg205,00€5mg537,00€10mg858,00€25mg1.251,00€50mg1.639,00€100mg2.277,00€1mL*10mM (DMSO)520,00€KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Fórmula:C24H19ClF2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:484.88Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Cor e Forma:SolidPeso molecular:430.46KRAS G12C inhibitor 13
CAS:KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Fórmula:C40H46F3N7O4Pureza:98%Cor e Forma:SolidPeso molecular:745.83RPR203494
CAS:RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.Fórmula:C26H29FN6O4Cor e Forma:SolidPeso molecular:508.54HPK1-IN-37
CAS:HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.Fórmula:C27H35N7O4Cor e Forma:SolidPeso molecular:521.61PROTAC KRAS G12C degrader-3
CAS:PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].Fórmula:C63H75ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1159.81ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Fórmula:C23H20ClN7O2SCor e Forma:SolidPeso molecular:493.97Deltasonamide 1
CAS:Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.Fórmula:C30H39ClN6O4S2Cor e Forma:SolidPeso molecular:647.25(aS)-PH-797804
CAS:(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].Fórmula:C22H19BrF2N2O3Cor e Forma:SolidPeso molecular:477.3KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Fórmula:C31H38N6O3Pureza:98%Cor e Forma:SolidPeso molecular:542.67
