MEK
MEK é uma quinase de dupla especificidade que desempenha um papel central na via de sinalização MAPK/ERK, ativando ERK por meio de fosforilação. A sinalização de MEK é crucial para a regulação do crescimento, sobrevivência e diferenciação celular. A atividade anômala de MEK tem sido implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um importante alvo terapêutico. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de MEK para apoiar sua pesquisa em oncologia, sinalização celular e desenvolvimento terapêutico.
Foram encontrados 73 produtos de "MEK"
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Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
<p>Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as</p>Cor e Forma:Lyophilized PowderPeso molecular:16.46 kDa (predicted) same as Tris-Bis PAGE result.Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Cor e Forma:SolidPeso molecular:431.2zapnometinib
CAS:<p>Zapnometinib (ATR-002) is a MEK inhibitor.</p>Fórmula:C13H7ClF2INO2Pureza:99.67%Cor e Forma:SolidPeso molecular:409.55Ro 5126766
CAS:<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Cor e Forma:SolidPeso molecular:471.46anemarsaponin B
CAS:<p>Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity</p>Fórmula:C45H74O18Pureza:99.06% - 99.81%Cor e Forma:SolidPeso molecular:903.06BIX02189
CAS:<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Fórmula:C27H28N4O2Pureza:97.84%Cor e Forma:SolidPeso molecular:440.54PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Cor e Forma:Yellow SolidPeso molecular:267.28CI-1040
CAS:<p>CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).</p>Fórmula:C17H14ClF2IN2O2Pureza:99.64%Cor e Forma:Off-White To Pale Beige SolidPeso molecular:478.66Refametinib
CAS:<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Fórmula:C19H20F3IN2O5SPureza:99.53% - >99.99%Cor e Forma:SolidPeso molecular:572.34RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63Selumetinib
CAS:<p>Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C17H15BrClFN4O3Pureza:98.1% - 99.90%Cor e Forma:White Or Pale White SolidPeso molecular:457.68TAK-733
CAS:<p>TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C17H15F2IN4O4Pureza:98.31% - 99.53%Cor e Forma:SolidPeso molecular:504.23APS-2-79
CAS:<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Fórmula:C23H21N3O3Cor e Forma:SolidPeso molecular:387.43Trametinib (DMSO solvate)
CAS:<p>Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)</p>Fórmula:C28H29FIN5O5SPureza:98.82% - 99.92%Cor e Forma:SolidPeso molecular:693.53Binimetinib
CAS:<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Cor e Forma:SolidPeso molecular:441.23GW 284543 hydrochloride
CAS:<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Fórmula:C23H21ClN2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:408.87Mirdametinib
CAS:<p>Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.</p>Fórmula:C16H14F3IN2O4Pureza:99.11% - 99.63%Cor e Forma:White PowderPeso molecular:482.19GDC-0623
CAS:<p>GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.</p>Fórmula:C16H14FIN4O3Pureza:98.95% - 99.02%Cor e Forma:SolidPeso molecular:456.21AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Fórmula:C16H17FIN3O4Pureza:98.72%Cor e Forma:SolidPeso molecular:461.23Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Fórmula:C4H3AuNa2O4SPureza:99.66%Cor e Forma:SoildPeso molecular:390.07
