MEK
MEK é uma quinase de dupla especificidade que desempenha um papel central na via de sinalização MAPK/ERK, ativando ERK por meio de fosforilação. A sinalização de MEK é crucial para a regulação do crescimento, sobrevivência e diferenciação celular. A atividade anômala de MEK tem sido implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um importante alvo terapêutico. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de MEK para apoiar sua pesquisa em oncologia, sinalização celular e desenvolvimento terapêutico.
Foram encontrados 74 produtos para "MEK".
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Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.82Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Fórmula:C14H23ClN2OPureza:99.83% - 99.92%Cor e Forma:SolidPeso molecular:270.798Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Fórmula:C14H22N2OPureza:99.88% - >99.99%Cor e Forma:White SolidPeso molecular:234.34PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:476.23Ref: TM-T21980
1mg60,00€5mg131,00€1mL*10mM (DMSO)152,00€10mg178,00€25mg314,00€50mg447,00€100mg622,00€500mg1.224,00€MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Cor e Forma:Odour SolidRef: TM-L1400
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarCobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Fórmula:C21H21F3IN3O2Pureza:98%Cor e Forma:SolidPeso molecular:531.318MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Fórmula:C28H23F3IN3O4Cor e Forma:SolidPeso molecular:649.4NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Fórmula:C22H18F2N4O5SPureza:98.62% - 98.86%Cor e Forma:White SolidPeso molecular:488.46DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Fórmula:C25H26ClN5O2Cor e Forma:SolidPeso molecular:463.96MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Fórmula:C50H65F3IN7O6SPureza:98%Cor e Forma:SolidPeso molecular:1076.06U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFórmula:C8H10N4S2Pureza:98%Cor e Forma:SolidPeso molecular:226.32MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Fórmula:C13H10FN3O2SCor e Forma:SolidPeso molecular:291.3FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Cor e Forma:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarMidkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asCor e Forma:Lyophilized PowderPeso molecular:16.46 kDa (predicted) same as Tris-Bis PAGE result.Ref: TM-TMPK-00024
5µg94,00€10µg138,00€20µg220,00€50µg434,00€100µg732,00€200µg1.324,00€500µg2.925,00€Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Cor e Forma:Odour LiquidMidkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPureza:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCCor e Forma:Transparent SolutionPeso molecular:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPureza:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGECor e Forma:White Lyophilized PowderPeso molecular:16.46 kDa (predicted) same as Tris-Bis PAGE result.Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Fórmula:C26H23FIN5O4Pureza:98% - 99.96%Cor e Forma:SolidPeso molecular:615.39CI-1040
CAS:CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).Fórmula:C17H14ClF2IN2O2Pureza:99.64%Cor e Forma:Off-White To Pale Beige SolidPeso molecular:478.66zapnometinib
CAS:Zapnometinib (ATR-002) is a MEK inhibitor.Fórmula:C13H7ClF2INO2Pureza:99.67%Cor e Forma:SolidPeso molecular:409.55Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Cor e Forma:White SolidPeso molecular:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)112,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFórmula:C45H74O18Pureza:99.06% - 99.11%Cor e Forma:SolidPeso molecular:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Fórmula:C27H28N4O2Pureza:97.84%Cor e Forma:SolidPeso molecular:440.54Ref: TM-T21295
2mg33,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg71,00€25mg119,00€50mg198,00€100mg296,00€200mg427,00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Fórmula:C16H13NO3Pureza:98.63% - >99.99%Cor e Forma:Green SolidPeso molecular:267.28Ref: TM-T2623
5mg38,00€10mg50,00€1mL*10mM (DMSO)55,00€25mg78,00€50mg101,00€100mg168,00€200mg250,00€500mg421,00€Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Cor e Forma:SolidPeso molecular:431.2Ref: TM-T6131
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg58,00€25mg96,00€50mg140,00€100mg207,00€200mg270,00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Fórmula:C19H20F3IN2O5SPureza:99.85% - >99.99%Cor e Forma:SolidPeso molecular:572.34Ref: TM-T6636
2mg43,00€5mg63,00€1mL*10mM (DMSO)79,00€10mg93,00€25mg147,00€50mg222,00€100mg326,00€200mg485,00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H15BrClFN4O3Pureza:98.1% - 99.90%Cor e Forma:White SolidPeso molecular:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Fórmula:C17H15F2IN4O4Pureza:98.31% - 99.2%Cor e Forma:SolidPeso molecular:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Fórmula:C23H21N3O3Cor e Forma:SolidPeso molecular:387.43Trametinib (DMSO solvate)
CAS:Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)Fórmula:C28H29FIN5O5SPureza:99.71% - 99.92%Cor e Forma:SolidPeso molecular:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Cor e Forma:SolidPeso molecular:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Fórmula:C23H21ClN2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:408.87Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Fórmula:C16H14F3IN2O4Pureza:99.11% - 99.63%Cor e Forma:White SolidPeso molecular:482.19Ref: TM-T6189
5mg49,00€1mL*10mM (DMSO)52,00€10mg71,00€25mg120,00€50mg172,00€100mg259,00€200mg385,00€500mg627,00€1g850,00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Fórmula:C16H14FIN4O3Pureza:98.95% - 99.02%Cor e Forma:SolidPeso molecular:456.21Ref: TM-T6843
1mg50,00€2mg70,00€5mg113,00€1mL*10mM (DMSO)113,00€10mg177,00€25mg265,00€50mg349,00€100mg580,00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Fórmula:C16H17FIN3O4Pureza:98.72% - 99.91%Cor e Forma:SolidPeso molecular:461.23Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Fórmula:C4H3AuNa2O4SPureza:99.19%Cor e Forma:SolidPeso molecular:390.07Ref: TM-T20168
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultarPimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Fórmula:C15H16ClFIN3O3Cor e Forma:SolidPeso molecular:467.66SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Cor e Forma:SolidPeso molecular:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Fórmula:C17H13BrClF2IN2O2Pureza:99.40%Cor e Forma:SolidPeso molecular:557.56Ref: TM-T21635
1mg35,00€2mg49,00€5mg74,00€10mg119,00€25mg259,00€50mg430,00€100mg620,00€200mg888,00€500mg1.333,00€BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Cor e Forma:Yellow SolidPeso molecular:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Fórmula:C18H16N6S2·C2H6OPureza:99.72% - 99.88%Cor e Forma:SolidPeso molecular:426.6trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFórmula:C10H13N5OPureza:97.13% - 98.96%Cor e Forma:White SolidPeso molecular:219.24Ref: TM-TMS2181
1mL*10mM (DMSO)33,00€10mg37,00€25mg52,00€50mg66,00€100mg96,00€200mg128,00€500mg205,00€Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C21H21F3IN3O2Pureza:98% - 99.96%Cor e Forma:White SolidPeso molecular:531.31Ref: TM-T3623
500mgA consultar1mg38,00€2mg49,00€5mg80,00€10mg90,00€1mL*10mM (DMSO)94,00€25mg170,00€50mg261,00€100mg429,00€U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Fórmula:C18H16N6S2Pureza:99.61%Cor e Forma:White SolidPeso molecular:380.49APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Cor e Forma:SolidPeso molecular:423.89Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Fórmula:C16H12O7Pureza:99.20% - >99.99%Cor e Forma:Yellow SolidPeso molecular:316.26Ref: TM-T2836
1mg38,00€2mg49,00€5mg78,00€1mL*10mM (DMSO)81,00€10mg113,00€25mg222,00€50mg371,00€100mg532,00€PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Fórmula:C16H13BrF3IN2O4Pureza:99.60%Cor e Forma:White SolidPeso molecular:561.09RO4987655
CAS:RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).Fórmula:C20H19F3IN3O5Pureza:98.21%Cor e Forma:White SolidPeso molecular:565.28GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.42
