MEK
MEK é uma quinase de dupla especificidade que desempenha um papel central na via de sinalização MAPK/ERK, ativando ERK por meio de fosforilação. A sinalização de MEK é crucial para a regulação do crescimento, sobrevivência e diferenciação celular. A atividade anômala de MEK tem sido implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um importante alvo terapêutico. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de MEK para apoiar sua pesquisa em oncologia, sinalização celular e desenvolvimento terapêutico.
Foram encontrados 73 produtos de "MEK"
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Trametinib
CAS:<p>Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.</p>Fórmula:C26H23FIN5O4Pureza:98% - 99.96%Cor e Forma:SolidPeso molecular:615.39RO4987655
CAS:<p>RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).</p>Fórmula:C20H19F3IN3O5Pureza:98.21%Cor e Forma:SolidPeso molecular:565.28GW284543
CAS:<p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>Fórmula:C23H20N2O3Pureza:99.75%Cor e Forma:SolidPeso molecular:372.42Trametiglue
CAS:<p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>Fórmula:C25H24FIN6O5SCor e Forma:SolidPeso molecular:666.46PD 334581
CAS:<p>MEK1 inhibitor</p>Fórmula:C20H19F3IN5O2Pureza:98%Cor e Forma:SolidPeso molecular:545.3Avutometinib potassium
CAS:<p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>Fórmula:C21H17FKN5O5SCor e Forma:SolidPeso molecular:509.55(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Fórmula:C16H14ClF2IN2O4Cor e Forma:SolidPeso molecular:498.65MEK inhibitor
CAS:<p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>Fórmula:C26H26N4O2Pureza:97.48%Cor e Forma:SolidPeso molecular:426.51JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Fórmula:C24H21BrFN5O5SCor e Forma:SolidPeso molecular:590.42MEK-IN-1
CAS:<p>MEK-IN-1 is a MEK inhibitor.</p>Fórmula:C24H20N4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.44MEK-IN-4
CAS:<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Fórmula:C21H18N4OSPureza:98.35% - 99.16%Cor e Forma:SolidPeso molecular:374.46(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Cor e Forma:SolidPeso molecular:380.49MS934
CAS:<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Fórmula:C52H69F3IN7O6SPureza:98%Cor e Forma:SolidPeso molecular:1104.11Cobimetinib racemate
CAS:<p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>Fórmula:C21H21F3IN3O2Pureza:98.00% - 99.71%Cor e Forma:SolidPeso molecular:531.31MEK-IN-6 hydrate
CAS:<p>MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].</p>Fórmula:C18H22FN3O5SPureza:98%Cor e Forma:SolidPeso molecular:411.45GSK1790627
CAS:<p>GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].</p>Fórmula:C24H21FIN5O3Cor e Forma:SolidPeso molecular:573.36Nedometinib
CAS:<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Fórmula:C17H16FIN4O3Pureza:99.18%Cor e Forma:SolidPeso molecular:470.24Luvometinib
CAS:<p>Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.</p>Fórmula:C26H22F2IN5O4SCor e Forma:SolidPeso molecular:665.45Refametinib R enantiomer
CAS:<p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>Fórmula:C19H20F3IN2O5SPureza:99.86%Cor e Forma:SolidPeso molecular:572.34MEK4 inhibitor-2
CAS:<p>MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.</p>Fórmula:C20H15FN4O3SCor e Forma:SolidPeso molecular:410.42EBI-1051
CAS:<p>EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).</p>Fórmula:C18H15F2IN2O5Pureza:98%Cor e Forma:SolidPeso molecular:504.22G-479
CAS:<p>G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.</p>Fórmula:C16H15FIN5O4Cor e Forma:SolidPeso molecular:487.22MEK1/2-IN-2
<p>MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.</p>Fórmula:C28H22ClFN6OCor e Forma:SolidPeso molecular:512.97
