Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 154 produtos de "Ras"
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Ketoconazole
CAS:Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Fórmula:C26H28Cl2N4O4Pureza:99.53% - 99.95%Cor e Forma:Crystals From 4-Methylpentanone SolidPeso molecular:531.43K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Fórmula:C31H33ClN4O4Pureza:99.00%Cor e Forma:SolidPeso molecular:561.07Ref: TM-T11738
1mg71,00€5mg161,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€1mL*10mM (DMSO)192,00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Cor e Forma:SolidPeso molecular:430.84Ref: TM-T10376
1mg38,00€5mg86,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€1mL*10mM (DMSO)88,00€HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Fórmula:C19H21N3OSPureza:98.05%Cor e Forma:SolidPeso molecular:339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Cor e Forma:SolidPeso molecular:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€1mL*10mM (DMSO)166,00€BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 99.52%Cor e Forma:SolidPeso molecular:338.41Ref: TM-T16021
1mg34,00€2mg49,00€5mg74,00€10mg105,00€25mg197,00€50mg356,00€100mg537,00€1mL*10mM (DMSO)82,00€G12 TFA
G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.Fórmula:C54H96F3N15O17Peso molecular:1283.70607KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Fórmula:C51H65F4N9O9S2Cor e Forma:SolidPeso molecular:1088.24KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Fórmula:C18H26N6OPeso molecular:342.21681Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Fórmula:C74H117N19O23SPureza:98%Cor e Forma:SolidPeso molecular:1671.93KRAS inhibitor-42
KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.Fórmula:C34H47ClN8O4S2Cor e Forma:SolidPeso molecular:730.28502KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Fórmula:C109H183N43O25S2Cor e Forma:SolidPeso molecular:2560.02pan-KRAS-IN-10
Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.Fórmula:C45H57N7O5SPeso molecular:807.41419MC 976
CAS:MC 976 is a derivative of Vitamin D3.Fórmula:C27H42O3Pureza:98%Cor e Forma:SolidPeso molecular:414.63MRTF-A-IN-2
MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Cor e Forma:Odour SolidADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Fórmula:C26H24FNO5Pureza:97.75%Cor e Forma:SoildPeso molecular:449.47Ref: TM-T85316
1mg47,00€5mg96,00€10mg124,00€25mg200,00€50mg353,00€100mg602,00€200mg982,00€1mL*10mM (DMSO)104,00€MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Cor e Forma:Odour SolidRef: TM-L1400
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar6-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Fórmula:C10H12N5Na4O13P3SCor e Forma:SolidPeso molecular:626.89559SEPT9-IN-1
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.Fórmula:C26H30ClN3O3Cor e Forma:SolidPeso molecular:467.988
