Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 167 produtos para "Ras".
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CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:408.88Phellodendrine chloride
CAS:Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Fórmula:C20H24ClNO4Pureza:98.85% - 99.05%Cor e Forma:SolidPeso molecular:377.86Ref: TM-T5S0777
5mg50,00€1mL*10mM (DMSO)58,00€10mg71,00€25mg101,00€50mg150,00€100mg215,00€200mg318,00€APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Fórmula:C23H16F8N4O3Pureza:99.39%Cor e Forma:White SolidPeso molecular:548.39Ref: TM-T8843
2mg37,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg120,00€25mg236,00€50mg380,00€100mg583,00€200mg785,00€ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFórmula:C14H11BrO3Pureza:99.12%Cor e Forma:SolidPeso molecular:307.139Ref: TM-T21970
5mg62,00€1mL*10mM (DMSO)67,00€10mg90,00€25mg133,00€50mg192,00€100mg286,00€500mg687,00€CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Cor e Forma:White SolidPeso molecular:486.38Ref: TM-T8930
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg85,00€25mg159,00€50mg244,00€100mg359,00€200mg512,00€SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Fórmula:C24H28N2O9SPureza:95.65%Cor e Forma:SolidPeso molecular:520.55ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:White SolidPeso molecular:385.5KRAS inhibitor-9
CAS:KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.Fórmula:C13H9ClN2S2Pureza:99.66%Cor e Forma:White SolidPeso molecular:292.81Ref: TM-T8756
1mg57,00€2mg81,00€5mg113,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg334,00€50mg485,00€100mg622,00€CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Fórmula:C18H13ClF6N2O3Pureza:99.80%Cor e Forma:SolidPeso molecular:454.75Ref: TM-T2014
5mg35,00€1mL*10mM (DMSO)40,00€10mg54,00€25mg90,00€50mg154,00€100mg248,00€200mg385,00€500mg625,00€K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34Oncrasin-1
CAS:Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrationsFórmula:C16H12ClNOPureza:99.75%Cor e Forma:White SolidPeso molecular:269.73FTI-277 hydrochloride
CAS:FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Fórmula:C22H30ClN3O3S2Pureza:97.57% - 97.61%Cor e Forma:SolidPeso molecular:484.07Ref: TM-T2700
1mg50,00€2mg70,00€5mg90,00€1mL*10mM (DMSO)102,00€10mg158,00€25mg304,00€50mg497,00€100mg708,00€200mg964,00€RBC8
CAS:RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Fórmula:C25H20N4O3Pureza:98.44% - 99.81%Cor e Forma:White SolidPeso molecular:424.45Ref: TM-T6634
1mg46,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg147,00€25mg281,00€50mg447,00€100mg650,00€200mg888,00€Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Fórmula:C32H35ClFN7O2Pureza:99.10% - 99.9%Cor e Forma:SolidPeso molecular:604.12Lonafarnib
CAS:Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).Fórmula:C27H31Br2ClN4O2Pureza:98% - 99.94%Cor e Forma:White SolidPeso molecular:638.82(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Cor e Forma:SolidPeso molecular:560.594Ref: TM-T22258
2mg34,00€5mg50,00€1mL*10mM (DMSO)73,00€10mg80,00€25mg147,00€50mg259,00€100mg404,00€500mg888,00€K-Ras(G12C) inhibitor 12
CAS:K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C15H17ClIN3O3Pureza:97.16%Cor e Forma:SolidPeso molecular:449.67NSC 23766 trihydrochloride
CAS:NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Fórmula:C24H35N7·3HClPureza:96.48% - 99.54%Cor e Forma:SolidPeso molecular:530.96MLS000532223
CAS:MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Fórmula:C15H9NO3Pureza:98.6%Cor e Forma:SolidPeso molecular:251.24Ref: TM-T8473
1mg105,00€5mg250,00€1mL*10mM (DMSO)301,00€10mg401,00€25mg685,00€50mg982,00€100mg1.341,00€ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Fórmula:C19H19NO3Pureza:99.06% - 99.23%Cor e Forma:SolidPeso molecular:309.36Ref: TM-T4619
1mg37,00€2mg50,00€5mg66,00€1mL*10mM (DMSO)84,00€10mg94,00€25mg190,00€50mg268,00€100mg374,00€500mg884,00€Rhosin hydrochloride
CAS:Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases.Cost-effective and quality-assured.Fórmula:C20H20Cl2N6OPureza:97.51% - 98.92%Cor e Forma:SolidPeso molecular:431.318ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Fórmula:C22H25ClFN7O2Pureza:99.76% - 99.81%Cor e Forma:White SolidPeso molecular:473.93ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.856H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Cor e Forma:SolidPeso molecular:590.14Ref: TM-T7326
1mg65,00€2mg90,00€5mg127,00€1mL*10mM (DMSO)166,00€10mg217,00€25mg358,00€50mg538,00€100mg765,00€Sotorasib
CAS:Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:560.594Ref: TM-T8684
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)93,00€10mg119,00€25mg213,00€50mg354,00€100mg434,00€500mg973,00€1g1.288,00€BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Cor e Forma:SolidPeso molecular:334.3CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Cor e Forma:SolidPeso molecular:478.82Ref: TM-T22062
5mg35,00€1mL*10mM (DMSO)40,00€10mg54,00€25mg108,00€50mg178,00€100mg286,00€200mg425,00€BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58Ref: TM-T5418
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg177,00€25mg321,00€50mg482,00€100mg710,00€200mg982,00€ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Cor e Forma:SolidPeso molecular:584.89Ref: TM-T1855
5mg52,00€1mL*10mM (DMSO)63,00€10mg74,00€25mg129,00€50mg210,00€100mg294,00€200mg470,00€500mg763,00€Arglabin
CAS:Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Fórmula:C15H18O3Pureza:98.97% - 99.62%Cor e Forma:SolidPeso molecular:246.3Ref: TM-TQ0165
1mg84,00€2mg123,00€5mg227,00€1mL*10mM (DMSO)251,00€10mg341,00€25mg492,00€50mg655,00€100mg982,00€200mg1.314,00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Cor e Forma:SolidPeso molecular:419.31MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Cor e Forma:White SolidPeso molecular:377.46Ref: TM-T22106
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Fórmula:C22H30O2SPureza:99.45%Cor e Forma:SolidPeso molecular:358.54Ref: TM-T6163
5mg34,00€1mL*10mM (DMSO)39,00€10mg50,00€25mg90,00€50mg150,00€100mg210,00€200mg344,00€500mg567,00€EHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Fórmula:C25H30N6OPureza:98.99% - >99.99%Cor e Forma:SolidPeso molecular:430.55Ref: TM-T2427
5mg46,00€1mL*10mM (DMSO)49,00€10mg70,00€25mg120,00€50mg202,00€100mg316,00€200mg467,00€500mg747,00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Cor e Forma:SolidPeso molecular:182.24Ref: TM-T8870
1mg49,00€1mL*10mM (DMSO)96,00€5mg144,00€10mg195,00€25mg273,00€50mg383,00€100mg532,00€200mg718,00€CID-1067700
CAS:CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).Fórmula:C18H18N2O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:390.48Ref: TM-T7558
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg105,00€25mg178,00€50mg234,00€100mg303,00€ARS-853
CAS:ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFórmula:C22H29ClN4O3Pureza:97.43% - 98.4%Cor e Forma:SolidPeso molecular:432.94Ref: TM-T7414
1mg142,00€1mL*10mM (DMSO)338,00€5mg353,00€10mg525,00€25mg843,00€50mg1.144,00€100mg1.549,00€500mg3.087,00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Cor e Forma:SolidPeso molecular:444.86Ref: TM-T7764
2mg39,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg94,00€25mg172,00€50mg260,00€100mg371,00€200mg530,00€(Rac)-Antineoplaston A10
CAS:Antineoplaston A10 is the first identified human antineoplaston, naturally occurring with anti-proliferative properties.Fórmula:C13H14N2O3Pureza:98.41%Cor e Forma:White SolidPeso molecular:246.26Ref: TM-T5379
1mg38,00€5mg84,00€1mL*10mM (DMSO)90,00€10mg122,00€25mg198,00€50mg295,00€100mg424,00€200mg593,00€Y16
CAS:Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.Fórmula:C24H20N2O3Pureza:98.26% - 99.85%Cor e Forma:SolidPeso molecular:384.43Ref: TM-T3553
1mg34,00€2mg48,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg109,00€25mg177,00€50mg263,00€100mg389,00€ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Fórmula:C21H17ClF2N4O2Pureza:98.86%Cor e Forma:White SolidPeso molecular:430.84Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T9407
1mg38,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg193,00€50mg323,00€100mg460,00€200mg620,00€Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Fórmula:C19H18O8Pureza:98.76% - 99.57%Cor e Forma:White SolidPeso molecular:374.34CASIN
CAS:CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Fórmula:C20H22N2OPureza:98.18% - >99.99%Cor e Forma:SolidPeso molecular:306.4Ref: TM-T3971
1mg35,00€2mg50,00€5mg71,00€1mL*10mM (DMSO)71,00€10mg114,00€25mg178,00€50mg268,00€100mg413,00€500mg888,00€EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Cor e Forma:SolidPeso molecular:581.47ML141
CAS:ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Fórmula:C22H21N3O3SPureza:99.36% - 99.56%Cor e Forma:SolidPeso molecular:407.49Ref: TM-T2463
1mg37,00€2mg52,00€5mg69,00€1mL*10mM (DMSO)71,00€10mg101,00€25mg200,00€50mg321,00€100mg515,00€Antineoplaston A10
CAS:Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.Fórmula:C13H14N2O3Pureza:99.42%Cor e Forma:White SolidPeso molecular:246.26Ref: TM-T7131
2mg44,00€5mg67,00€1mL*10mM (DMSO)73,00€10mg103,00€25mg193,00€50mg295,00€100mg425,00€200mg595,00€1A-116
CAS:1A-116 is a specific Rac1 inhibitor.Fórmula:C16H16F3N3Pureza:99.71%Cor e Forma:SolidPeso molecular:307.31Ref: TM-T14004
1mg52,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg158,00€25mg268,00€50mg421,00€100mg620,00€200mg875,00€Kobe0065
CAS:Kobe0065: novel small-molecule, inhibits Ras–Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Fórmula:C15H11ClF3N5O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:449.79K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.78Ref: TM-T6556
1mg34,00€5mg78,00€10mg108,00€1mL*10mM (DMSO)108,00€25mg215,00€50mg311,00€100mg425,00€200mg597,00€
