ERK
ERK é uma proteína chave na via de sinalização MAPK (Mitogen-Activated Protein Kinase), que está envolvida na transmissão de sinais dos receptores de superfície celular para o DNA no núcleo da célula. ERK desempenha um papel crucial na regulação de vários processos celulares, incluindo proliferação, diferenciação e sobrevivência. A desregulação da sinalização ERK está associada ao desenvolvimento de câncer e outras doenças, tornando-a um alvo importante para intervenções terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores e moduladores de ERK de alta qualidade para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 204 produtos de "ERK"
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ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Cor e Forma:SolidPeso molecular:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:469.79PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Fórmula:C22H16F2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:406.38CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Cor e Forma:SolidPeso molecular:459.3BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:282.29Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OPureza:98.31%Cor e Forma:SolidPeso molecular:454.53Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOCor e Forma:SolidPeso molecular:276.13ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Fórmula:C24H23Cl2FN4O2Cor e Forma:SolidPeso molecular:489.37ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Fórmula:C22H18Cl2N4O2S2Cor e Forma:SolidPeso molecular:505.44GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Fórmula:C26H21F3N4OCor e Forma:SolidPeso molecular:462.47Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Cor e Forma:SolidPeso molecular:326.35PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PCor e Forma:SolidPeso molecular:296.11mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Fórmula:C93H150N20O25Pureza:99.26%Cor e Forma:SolidPeso molecular:1948.312,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Fórmula:C12H10O2Pureza:99.66%Cor e Forma:White To Grey-Brownish PowderPeso molecular:186.21Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SCor e Forma:SolidPeso molecular:456.89D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.4ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Cor e Forma:SolidPeso molecular:550.05UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Cor e Forma:SolidPeso molecular:403.9ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Fórmula:C16H11Cl2FN4O2Cor e Forma:SolidPeso molecular:381.19Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Fórmula:C8H16O2S2Pureza:97.51%Cor e Forma:Yellow To Orange LiquidPeso molecular:208.34
