p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Foram encontrados 117 produtos de "p38 MAPK"
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Dihydrocaffeic acid
CAS:<p>Dihydrocaffeic acid, a chlorogenic acid metabolite, has antioxidant, anti-Alzheimer's, neuroprotective, and lipid-lowering properties.</p>Fórmula:C9H10O4Pureza:98.63%Cor e Forma:SolidPeso molecular:182.17Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:White Solid CrystallinePeso molecular:180.16PF-3644022
CAS:<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Fórmula:C21H18N4OSPureza:98.13%Cor e Forma:SolidPeso molecular:374.46Hesperetin
CAS:<p>Hesperetin belongs to the flavanone class of flavonoids.</p>Fórmula:C16H14O6Pureza:98.45% - 99.27%Cor e Forma:SolidPeso molecular:302.28Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Cor e Forma:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64LXH254
CAS:<p>LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.</p>Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Cor e Forma:SolidPeso molecular:502.49Carbimazole
CAS:<p>Carbimazole, an imidazolium-based thyroid blocker, turns to MMI in the body. Used in Graves' disease research.</p>Fórmula:C7H10N2O2SPureza:99.98%Cor e Forma:SolidPeso molecular:186.23AZD7624
CAS:<p>AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.</p>Fórmula:C27H30FN5O3Pureza:98.82%Cor e Forma:SolidPeso molecular:491.56Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Fórmula:C8H12BrNO3Pureza:98.22% - 99.88%Cor e Forma:Beige To Brown Fine Crystalline PowderPeso molecular:250.09Dilmapimod
CAS:<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Fórmula:C23H19F3N4O3Pureza:97.53%Cor e Forma:SolidPeso molecular:456.42Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Fórmula:C22H24ClNO4Pureza:99.53%Cor e Forma:SolidPeso molecular:401.88BI-3406
CAS:<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.46SB220025
CAS:<p>SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.</p>Fórmula:C18H19FN6Pureza:99.44%Cor e Forma:SolidPeso molecular:338.38p38α inhibitor 3
CAS:<p>p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.</p>Fórmula:C19H20FNOPureza:99.94%Cor e Forma:SoildPeso molecular:297.37p38 MAP Kinase Inhibitor Ⅵ
CAS:<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Fórmula:C16H13FN2OS2Pureza:98.53%Cor e Forma:SolidPeso molecular:332.42p38α inhibitor 5
CAS:<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Fórmula:C26H23BrF2N2O3Cor e Forma:SolidPeso molecular:529.37WYE-687
CAS:<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Fórmula:C28H32N8O3Pureza:99.93%Cor e Forma:SolidPeso molecular:528.61Z16078526
CAS:<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Fórmula:C18H17N3O4SPureza:98.93%Cor e Forma:SolidPeso molecular:371.41Talmapimod hydrochloride
CAS:<p>Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.</p>Fórmula:C27H31Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46PDE4-IN-26
<p>PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.</p>Fórmula:C22H18F2N4O3SCor e Forma:SolidPeso molecular:456.47Ro-3201195
CAS:<p>Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.</p>Fórmula:C19H18FN3O4Pureza:99.15%Cor e Forma:SolidPeso molecular:371.36Cyclotraxin B
CAS:<p>TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.</p>Fórmula:C48H73N13O17S3Pureza:98%Cor e Forma:SolidPeso molecular:1200.36Esculin sesquihydrate
CAS:<p>Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimental</p>Fórmula:C15H16O9H2OPureza:98%Cor e Forma:SolidPeso molecular:367.31MAP3K5-IN-1
CAS:<p>Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].</p>Fórmula:C28H24N4O4Cor e Forma:SolidPeso molecular:480.51DB-10
<p>DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.</p>Cor e Forma:Odour SolidOVA-E1 peptide TFA
CAS:<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Fórmula:C49H77F3N10O16Pureza:98%Cor e Forma:SolidPeso molecular:1119.19R1487 Hydrochloride
CAS:<p>R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.</p>Fórmula:C19H19ClF2N4O3Pureza:99.42%Cor e Forma:SolidPeso molecular:424.83Kaempferol-3-O-glucorhamnoside
CAS:<p>Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK</p>Fórmula:C27H30O15Pureza:96.96% - 98.17%Cor e Forma:SolidPeso molecular:594.5Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Cor e Forma:SolidPeso molecular:436.26Sertaconazole nitrate
CAS:<p>Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.</p>Fórmula:C20H15Cl3N2OS·HNO3Pureza:98.66% - 99.65%Cor e Forma:SolidPeso molecular:500.78ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Fórmula:C19H19N9O2Pureza:99.92%Cor e Forma:SolidPeso molecular:405.41SB 202190
CAS:<p>SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.</p>Fórmula:C20H14FN3OPureza:98% - 99.84%Cor e Forma:Pale YellowPeso molecular:331.34CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Fórmula:C42H72O14Pureza:99.42% - 99.65%Cor e Forma:SolidPeso molecular:801.01UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Cor e Forma:SolidPeso molecular:640.68Adezmapimod
CAS:<p>Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.</p>Fórmula:C21H16FN3OSPureza:99.42% - 99.93%Cor e Forma:White SolidPeso molecular:377.435,6,7-TRIMETHOXYFLAVONE
CAS:<p>5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.</p>Fórmula:C18H16O5Pureza:99.05% - 99.49%Cor e Forma:SolidPeso molecular:312.32SD 0006
CAS:<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Fórmula:C20H20ClN5O2Pureza:98.32%Cor e Forma:SolidPeso molecular:397.86Nitidine chloride
CAS:<p>1.</p>Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Cor e Forma:SolidPeso molecular:383.82SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Cor e Forma:SolidPeso molecular:368.4Rotundic acid
CAS:<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Fórmula:C30H48O5Pureza:96.91% - 99.97%Cor e Forma:SolidPeso molecular:488.7Cornuside
CAS:<p>Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.</p>Fórmula:C24H30O14Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:542.49Andrograpanin
CAS:<p>Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.</p>Fórmula:C20H30O3Pureza:99.03% - 99.457%Cor e Forma:SolidPeso molecular:318.45FERULIC ACID METHYL ESTER
CAS:<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Fórmula:C11H12O4Pureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:208.21BMS-582949 hydrochloride
CAS:<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Cor e Forma:SolidPeso molecular:442.95R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Fórmula:C19H18F2N4O3Pureza:99.77%Cor e Forma:SolidPeso molecular:388.37SR-318
CAS:<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Fórmula:C27H33N5O2Pureza:99.74%Cor e Forma:SolidPeso molecular:459.58Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Cor e Forma:SolidPeso molecular:718.08TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Fórmula:C20H13F2N3Pureza:99.35% - 99.79%Cor e Forma:SolidPeso molecular:333.33TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32Ralimetinib dimesylate
CAS:<p>Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.</p>Fórmula:C24H29FN6·2CH4O3SPureza:98% - 99.38%Cor e Forma:SolidPeso molecular:612.74Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Fórmula:C24H21F2NO4Pureza:99.56% - >99.99%Cor e Forma:SolidPeso molecular:425.42SKF-86002
CAS:<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Fórmula:C16H12FN3SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:297.35SB 242235
CAS:<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Fórmula:C19H20FN5OPureza:99.13% - 99.68%Cor e Forma:SolidPeso molecular:353.39Rhoifolin
CAS:<p>Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.</p>Fórmula:C27H30O14Pureza:98.11% - 98.58%Cor e Forma:SolidPeso molecular:578.52TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Fórmula:C24H21N3OSPureza:99.83%Cor e Forma:SolidPeso molecular:399.51PD 169316
CAS:<p>PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.</p>Fórmula:C20H13FN4O2Pureza:98.65%Cor e Forma:SolidPeso molecular:360.34AMG-47a
CAS:<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Fórmula:C29H28F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:535.56Acumapimod
CAS:<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Fórmula:C22H19N5O2Pureza:≥95%Cor e Forma:SolidPeso molecular:385.42Skatole
CAS:<p>Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.</p>Fórmula:C9H9NPureza:99.74%Cor e Forma:Leaves From Petroleum Ether; White-Brown Scales SolidPeso molecular:131.17MW-150
CAS:<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Fórmula:C24H23N5Pureza:97.35% - 99.27%Cor e Forma:SolidPeso molecular:381.47Isoliquiritin apioside
CAS:<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Fórmula:C26H30O13Pureza:98.84% - 99.27%Cor e Forma:SolidPeso molecular:550.51Esculin
CAS:<p>Esculin (Aesculin) is a glucoside found in horse chestnuts.</p>Fórmula:C15H16O9Pureza:97.93% - 99.83%Cor e Forma:Cream PowderPeso molecular:340.28Doramapimod
CAS:<p>Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.</p>Fórmula:C31H37N5O3Pureza:97.14% - 98.80%Cor e Forma:SolidPeso molecular:527.66Bakuchiol
CAS:<p>Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.</p>Fórmula:C18H24OPureza:98.04% - 99.05%Cor e Forma:Brownish Yellow Liquid ViscousPeso molecular:256.38PH-797804
CAS:<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Fórmula:C22H19BrF2N2O3Pureza:97.90% - 98.27%Cor e Forma:SolidPeso molecular:477.3Bisabolangelone
CAS:<p>Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.</p>Fórmula:C15H20O3Pureza:98.91%Cor e Forma:SolidPeso molecular:248.32SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Fórmula:C10H5ClN4O5SPureza:99.64%Cor e Forma:SolidPeso molecular:328.69AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Cor e Forma:SolidPeso molecular:503.58SD-169
CAS:<p>SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.</p>Fórmula:C9H8N2OPureza:98.6%Cor e Forma:SolidPeso molecular:160.17Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94N-Feruloyloctopamine
CAS:<p>N-Feruloyloctopamine is a natural product.</p>Fórmula:C18H19NO5Pureza:99.70%Cor e Forma:SolidPeso molecular:329.35Sesamolin
CAS:<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Fórmula:C20H18O7Pureza:98.77% - 99.04%Cor e Forma:SolidPeso molecular:370.35Pamapimod
CAS:<p>Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.</p>Fórmula:C19H20F2N4O4Pureza:99.52% - 99.99%Cor e Forma:SolidPeso molecular:406.38Losmapimod
CAS:<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Fórmula:C22H26FN3O2Pureza:98.35% - 99.89%Cor e Forma:SolidPeso molecular:383.46RWJ-67657
CAS:<p>RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.</p>Fórmula:C27H24FN3OPureza:99.66%Cor e Forma:SolidPeso molecular:425.5Sertaconazole
CAS:<p>Sertaconazole is a broad-spectrum antifungal.</p>Fórmula:C20H15Cl3N2OSPureza:99.483%Cor e Forma:SolidPeso molecular:437.77Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Talmapimod
CAS:<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:513BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C31H33FN6O3Pureza:99.07% - 99.66%Cor e Forma:SolidPeso molecular:556.63Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:428.44VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Cor e Forma:SolidPeso molecular:404.32TLC1566-0618
CAS:<p>TLC1566-0618 shows antitumor activity and targets stat.</p>Fórmula:C20H15NO3S3Pureza:98%Cor e Forma:SolidPeso molecular:413.53LY 294002 Hydrochloride
CAS:Produto Controlado<p>Applications LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>Fórmula:C19H17NO3·(HCl)Cor e Forma:NeatPeso molecular:343.8SB 706504
CAS:<p>SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in COPD.</p>Fórmula:C24H19F3N8OPureza:98.686%Cor e Forma:SolidPeso molecular:492.46AL 8697
CAS:<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Fórmula:C21H21F3N4OPureza:99.55% - 99.89%Cor e Forma:SolidPeso molecular:402.41PF-05381941
CAS:<p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>Fórmula:C27H26N6O2Pureza:98.04%Cor e Forma:SolidPeso molecular:466.53EO-1606
CAS:<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Fórmula:C21H17ClFNOPureza:98.28% - 98.84%Cor e Forma:SolidPeso molecular:353.82p38α inhibitor 4
CAS:<p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>Fórmula:C14H7F6N3OPureza:99.69%Cor e Forma:SolidPeso molecular:347.215UR13870
CAS:<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Fórmula:C24H16F2N4Pureza:99.18% - >99.99%Cor e Forma:SolidPeso molecular:398.41AKP-001
CAS:<p>AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.</p>Fórmula:C21H13ClF2N4O2Pureza:99.50% - 99.92%Cor e Forma:SolidPeso molecular:426.8p38 MAPK Inhibitor
CAS:<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Fórmula:C20H13ClFN3OPureza:99.91%Cor e Forma:SolidPeso molecular:365.79SB-747651A Dihydrochloride
CAS:<p>SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.</p>Fórmula:C16H24Cl2N8OPureza:98.05%Cor e Forma:SolidPeso molecular:415.32Org OD 02-0
CAS:<p>10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activate</p>Fórmula:C22H30O2Pureza:98%Cor e Forma:SolidPeso molecular:326.47p38-α MAPK-IN-1
CAS:<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Fórmula:C27H35N5O3Pureza:99.93%Cor e Forma:SolidPeso molecular:477.6PLK1/p38γ-IN-1
CAS:<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Fórmula:C21H26ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.9AMG-548 dihydrochloride (864249-60-5 free base)
<p>AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.</p>Fórmula:C29H29Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:534.48p38 Kinase inhibitor 4
CAS:<p>Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].</p>Fórmula:C12H9Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:282.13AMG-548 hydrochloride (864249-60-5 free base)
<p>AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective</p>Fórmula:C29H28ClN5OPureza:98%Cor e Forma:SolidPeso molecular:498.02p38-α MAPK-IN-9
CAS:<p>p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.</p>Fórmula:C19H20N8O2Cor e Forma:SolidPeso molecular:392.414PS-166276
CAS:<p>PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.</p>Fórmula:C20H30N8OCor e Forma:SolidPeso molecular:398.51Anti-osteoporosis agent-11
CAS:<p>Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.</p>Fórmula:C23H17NO2Se2Cor e Forma:SolidPeso molecular:497.31p38-α MAPK-IN-10
CAS:<p>p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.</p>Fórmula:C27H34Cl2N6Cor e Forma:SolidPeso molecular:513.50510-Methoxy-canthin-6-one
CAS:<p>10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.</p>Fórmula:C15H10N2O2Cor e Forma:SolidPeso molecular:250.25AMC-04
CAS:<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Fórmula:C26H28N2O3Cor e Forma:SolidPeso molecular:416.51p38 MAPK-IN-6
CAS:<p>p38 MAPK-IN-6 (compound c47) is an inhibitor of p38 MAPK, exhibiting a 14% inhibition rate at a concentration of 10 μM.</p>Fórmula:C16H14BrN3OS2Cor e Forma:SolidPeso molecular:408.336RIPK2-IN-6
CAS:<p>RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.</p>Fórmula:C26H21NO3Cor e Forma:SolidPeso molecular:395.45Lambertellin
CAS:<p>Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.</p>Fórmula:C14H8O5Cor e Forma:SolidPeso molecular:256.21PF-03715455
CAS:<p>PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.</p>Fórmula:C35H34ClN7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:700.27(R)-STU104-d6
CAS:<p>(R)-STU104-d6 is a deuterium-labeled variant of (R)-STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.</p>Fórmula:C18H182D6O4Cor e Forma:SolidPeso molecular:304.37p38 Kinase inhibitor 7
CAS:<p>p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.</p>Fórmula:C22H25FN6OCor e Forma:SolidPeso molecular:408.472p38 MAP Kinase-IN-1
CAS:<p>p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.</p>Fórmula:C20H19FN6OCor e Forma:SolidPeso molecular:378.403Emprumapimod
CAS:<p>Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.</p>Fórmula:C24H29F2N5O3Pureza:99.21% - >99.99%Cor e Forma:SolidPeso molecular:473.52
