p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Foram encontrados 112 produtos de "p38 MAPK"
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Oxidopamine hydrobromide
CAS:Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.Fórmula:C8H12BrNO3Pureza:98.22% - 99.88%Cor e Forma:Beige To Brown Fine Crystalline PowderPeso molecular:250.09BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Cor e Forma:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€SB220025
CAS:SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.Fórmula:C18H19FN6Pureza:99.44%Cor e Forma:SolidPeso molecular:338.38LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Cor e Forma:SolidPeso molecular:502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€Carbimazole
CAS:Carbimazole, an imidazolium-based thyroid blocker, turns to MMI in the body. Used in Graves' disease research.Fórmula:C7H10N2O2SPureza:99.98%Cor e Forma:SolidPeso molecular:186.23Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Fórmula:C23H19F3N4O3Pureza:97.53%Cor e Forma:SolidPeso molecular:456.42PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Cor e Forma:SolidPeso molecular:374.46Ref: TM-T16501
1mg37,00€5mg111,00€10mg202,00€25mg416,00€50mg620,00€100mg832,00€500mg1.663,00€1mL*10mM (DMSO)187,00€Hesperetin
CAS:Hesperetin belongs to the flavanone class of flavonoids.Fórmula:C16H14O6Pureza:98.45% - 99.27%Cor e Forma:SolidPeso molecular:302.28Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Cor e Forma:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64AZD7624
CAS:AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.Fórmula:C27H30FN5O3Pureza:98.82%Cor e Forma:SolidPeso molecular:491.56Ref: TM-T14381
1mg70,00€5mg152,00€10mg236,00€25mg432,00€50mg647,00€100mg964,00€1mL*10mM (DMSO)166,00€Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Fórmula:C22H24ClNO4Pureza:99.53%Cor e Forma:SolidPeso molecular:401.88Ref: TM-T10990
1mg55,00€5mg105,00€10mg152,00€25mg250,00€50mg375,00€100mg533,00€1mL*10mM (DMSO)117,00€Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:White Solid CrystallinePeso molecular:180.16Dihydrocaffeic acid
CAS:Dihydrocaffeic acid, a chlorogenic acid metabolite, has antioxidant, anti-Alzheimer's, neuroprotective, and lipid-lowering properties.Fórmula:C9H10O4Pureza:98.63%Cor e Forma:SolidPeso molecular:182.17PDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Fórmula:C22H18F2N4O3SCor e Forma:SolidPeso molecular:456.47p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:98.53%Cor e Forma:SolidPeso molecular:332.42OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Fórmula:C49H77F3N10O16Pureza:98%Cor e Forma:SolidPeso molecular:1119.19NR-11c
NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research.Fórmula:C59H71BrF2N10O8SPeso molecular:1198.22MAP3K5-IN-1
CAS:Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].Fórmula:C28H24N4O4Cor e Forma:SolidPeso molecular:480.51Esculin sesquihydrate
CAS:Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimentalFórmula:C15H16O9H2OPureza:98%Cor e Forma:SolidPeso molecular:367.31p38α inhibitor 5
CAS:The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Fórmula:C26H23BrF2N2O3Cor e Forma:SolidPeso molecular:529.37Talmapimod hydrochloride
CAS:Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.Fórmula:C27H31Cl2FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46p38α inhibitor 3
CAS:p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.Fórmula:C19H20FNOPureza:99.94%Cor e Forma:SoildPeso molecular:297.37Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.
Fórmula:C19H18FN3O4Pureza:99.15%Cor e Forma:SolidPeso molecular:371.36DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Cor e Forma:Odour SolidCyclotraxin B
CAS:TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.
Fórmula:C48H73N13O17S3Pureza:98%Cor e Forma:SolidPeso molecular:1200.36Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Cor e Forma:Odour SolidR1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Fórmula:C19H19ClF2N4O3Pureza:99.42%Cor e Forma:SolidPeso molecular:424.83FERULIC ACID METHYL ESTER
CAS:FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.Fórmula:C11H12O4Pureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:208.215,6,7-TRIMETHOXYFLAVONE
CAS:5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.Fórmula:C18H16O5Pureza:99.05% - 99.49%Cor e Forma:SolidPeso molecular:312.32BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Cor e Forma:SolidPeso molecular:442.95Ref: TM-T3462
1mg34,00€5mg67,00€10mg96,00€25mg161,00€50mg250,00€100mg371,00€200mg523,00€1mL*10mM (DMSO)73,00€Adezmapimod
CAS:Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.Fórmula:C21H16FN3OSPureza:99.42% - 99.93%Cor e Forma:White SolidPeso molecular:377.43SB 202190
CAS:SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.Fórmula:C20H14FN3OPureza:98% - 99.84%Cor e Forma:Pale YellowPeso molecular:331.34R1487
CAS:R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.Fórmula:C19H18F2N4O3Pureza:99.77%Cor e Forma:SolidPeso molecular:388.37UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Cor e Forma:SolidPeso molecular:640.68Ralimetinib dimesylate
CAS:Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.Fórmula:C24H29FN6·2CH4O3SPureza:98% - 99.38%Cor e Forma:SolidPeso molecular:612.74ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Cor e Forma:SolidPeso molecular:405.41Ref: TM-T9697
1mg90,00€5mg215,00€10mg321,00€25mg582,00€50mg873,00€100mg1.216,00€1mL*10mM (DMSO)236,00€Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:513Ref: TM-T12871
1mg50,00€2mg73,00€5mg109,00€10mg168,00€25mg358,00€50mg530,00€100mg758,00€1mL*10mM (DMSO)124,00€TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32Ref: TM-T4645
2mg34,00€5mg50,00€10mg80,00€25mg147,00€50mg224,00€100mg313,00€200mg439,00€1mL*10mM (DMSO)67,00€Skepinone-L
CAS:Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.Fórmula:C24H21F2NO4Pureza:99.56% - >99.99%Cor e Forma:SolidPeso molecular:425.42Ref: TM-T6130
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg208,00€50mg313,00€100mg465,00€1mL*10mM (DMSO)87,00€Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Fórmula:C27H30O14Pureza:98.11% - 98.58%Cor e Forma:SolidPeso molecular:578.52Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Fórmula:C51H82O21Pureza:99.51% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Fórmula:C24H30O14Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:542.49Ref: TM-T4S2326
1mg96,00€5mg264,00€10mg415,00€25mg677,00€50mg935,00€100mg1.254,00€500mg2.527,00€1mL*10mM (DMSO)315,00€Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Fórmula:C20H15Cl3N2OS·HNO3Pureza:98.66% - 99.65%Cor e Forma:SolidPeso molecular:500.78Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Fórmula:C30H48O5Pureza:96.91% - 99.97%Cor e Forma:SolidPeso molecular:488.70Ref: TM-T5S0506
2mg34,00€5mg49,00€10mg75,00€25mg137,00€50mg215,00€100mg319,00€200mg474,00€1mL*10mM (DMSO)49,00€Andrograpanin
CAS:Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.Fórmula:C20H30O3Pureza:99.03% - 99.457%Cor e Forma:SolidPeso molecular:318.45Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Fórmula:C20H15Cl3N2OSPureza:99.483%Cor e Forma:SolidPeso molecular:437.77Ref: TM-T50005
5mg55,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€200mg388,00€1mL*10mM (DMSO)79,00€Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Cor e Forma:SolidPeso molecular:801.01BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Ref: TM-T6789
1mg82,00€2mg114,00€5mg200,00€10mg284,00€25mg477,00€50mg692,00€100mg973,00€1mL*10mM (DMSO)200,00€Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Fórmula:C31H33FN6O3Pureza:99.07% - 99.66%Cor e Forma:SolidPeso molecular:556.63SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Fórmula:C16H12FN3SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:297.35
