p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Foram encontrados 115 produtos para "p38 MAPK".
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p38-α MAPK-IN-1
CAS:p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Fórmula:C27H35N5O3Pureza:99.93%Cor e Forma:SolidPeso molecular:477.6Ref: TM-T12347
1mg84,00€5mg170,00€1mL*10mM (DMSO)178,00€10mg266,00€25mg492,00€50mg737,00€100mg1.108,00€200mg1.485,00€AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Fórmula:C29H29Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:534.48Exarafenib
CAS:Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.Fórmula:C26H34F3N5O3Pureza:98.36% - 99.84%Cor e Forma:SolidPeso molecular:521.58Ref: TM-T63644
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg71,00€5mg152,00€1mL*10mM (DMSO)168,00€p38 MAP Kinase-IN-1
CAS:p38 MAP Kinase-IN-1 (Compound 4) is an inhibitor of p38, suitable for studies related to inflammation and autoimmune responses.Fórmula:C20H19FN6OCor e Forma:SolidPeso molecular:378.403(R)-STU104-D6
CAS:(R)-STU104-D6 is a deuterium-labeled variant of (R)-STU104 (T60657). This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.Fórmula:C18H182D6O4Cor e Forma:SolidPeso molecular:304.37p38-α MAPK-IN-10
CAS:p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.Fórmula:C27H34Cl2N6Cor e Forma:SolidPeso molecular:513.505PS-166276
CAS:PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Fórmula:C20H30N8OCor e Forma:SolidPeso molecular:398.5110-Methoxy-canthin-6-one
CAS:10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.Fórmula:C15H10N2O2Cor e Forma:SolidPeso molecular:250.25PF-03715455
CAS:PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.Fórmula:C35H34ClN7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:700.27AMC-04
CAS:AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Fórmula:C26H28N2O3Cor e Forma:SolidPeso molecular:416.51p38 MAPK-IN-6
CAS:p38 MAPK-IN-6 (compound c47) is an inhibitor of p38 MAPK, exhibiting a 14% inhibition rate at a concentration of 10 μM.Fórmula:C16H14BrN3OS2Cor e Forma:SolidPeso molecular:408.336p38-α MAPK-IN-9
CAS:p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.Fórmula:C19H20N8O2Cor e Forma:SolidPeso molecular:392.414P2L-003
CAS:P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.Fórmula:C23H25ClN4O3SPeso molecular:472.99p38 Kinase inhibitor 7
CAS:p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Fórmula:C22H25FN6OCor e Forma:SolidPeso molecular:408.472Emprumapimod
CAS:Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.Fórmula:C24H29F2N5O3Pureza:99.10% - >99.99%Cor e Forma:SolidPeso molecular:473.52
