p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Foram encontrados 115 produtos para "p38 MAPK".
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Skatole
CAS:Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.Fórmula:C9H9NPureza:99.74% - 99.96%Cor e Forma:White SolidPeso molecular:131.17MW-150
CAS:MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.Fórmula:C24H23N5Pureza:97.35% - 99.27%Cor e Forma:White SolidPeso molecular:381.47Ref: TM-T5494
1mg37,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg144,00€25mg289,00€50mg430,00€100mg620,00€500mg1.333,00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Fórmula:C26H30O13Pureza:98.84% - 99.27%Cor e Forma:SolidPeso molecular:550.51Esculin
CAS:Esculin (Aesculin) is a glucoside found in horse chestnuts.Fórmula:C15H16O9Pureza:97.93% - 99.83%Cor e Forma:White SolidPeso molecular:340.28Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFórmula:C27H30O15Pureza:96.96% - 98.17%Cor e Forma:SolidPeso molecular:594.5Ref: TM-T5S0089
1mg48,00€5mg92,00€1mL*10mM (DMSO)122,00€10mg136,00€25mg215,00€50mg323,00€100mg469,00€200mg647,00€Bakuchiol
CAS:Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.Fórmula:C18H24OPureza:98.04% - 99.44%Cor e Forma:Transparent OilPeso molecular:256.38PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Fórmula:C22H19BrF2N2O3Pureza:97.90% - 98.27%Cor e Forma:SolidPeso molecular:477.3Ref: TM-T1974
1mg43,00€5mg88,00€1mL*10mM (DMSO)92,00€10mg137,00€25mg241,00€50mg385,00€100mg595,00€500mg1.251,00€Ref: TM-T5S2358
1mg49,00€2mg69,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg137,00€25mg197,00€50mg295,00€100mg447,00€Bisabolangelone
CAS:Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.Fórmula:C15H20O3Pureza:98.91% - 99.65%Cor e Forma:White SolidPeso molecular:248.32SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64%Cor e Forma:SolidPeso molecular:328.69SD-169
CAS:SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.Fórmula:C9H8N2OPureza:98.6%Cor e Forma:White SolidPeso molecular:160.17Afatinib
CAS:Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.90%Cor e Forma:White SolidPeso molecular:485.94Ref: TM-T21312
5mg34,00€1mL*10mM (DMSO)35,00€10mg49,00€25mg81,00€50mg109,00€100mg137,00€200mg168,00€500mg284,00€N-Feruloyloctopamine
CAS:N-Feruloyloctopamine is a natural product.Fórmula:C18H19NO5Pureza:99.70%Cor e Forma:SolidPeso molecular:329.35Ref: TM-TN1968
1mg80,00€1mL*10mM (DMSO)159,00€5mg185,00€10mg273,00€25mg460,00€50mg657,00€100mg898,00€Sesamolin
CAS:Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Fórmula:C20H18O7Pureza:98.77% - 99.04%Cor e Forma:White SolidPeso molecular:370.35Ref: TM-T5S2283
1mg35,00€2mg50,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg120,00€25mg197,00€50mg294,00€100mg437,00€200mg622,00€Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Fórmula:C19H20F2N4O4Pureza:99.52% - 99.99%Cor e Forma:SolidPeso molecular:406.38Losmapimod
CAS:Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).Fórmula:C22H26FN3O2Pureza:98.35% - 99.89%Cor e Forma:SolidPeso molecular:383.46Ref: TM-T2277
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg73,00€25mg132,00€50mg213,00€100mg385,00€500mg873,00€RWJ-67657
CAS:RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.Fórmula:C27H24FN3OPureza:99.66%Cor e Forma:SolidPeso molecular:425.5Ref: TM-T16812
2mg44,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg90,00€25mg205,00€50mg331,00€100mg533,00€500mg1.125,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.57% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Cor e Forma:White SolidPeso molecular:513Ref: TM-T12871
1mg50,00€2mg73,00€5mg109,00€1mL*10mM (DMSO)124,00€10mg168,00€25mg358,00€50mg530,00€100mg758,00€BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Cor e Forma:SolidPeso molecular:406.48Ref: TM-T6789
1mg82,00€2mg114,00€5mg200,00€1mL*10mM (DMSO)200,00€10mg284,00€25mg477,00€50mg692,00€100mg973,00€
