Raf
As quinases Raf são componentes-chave da via de sinalização MAPK/ERK, desempenhando um papel crítico na transmissão de sinais da membrana celular para o núcleo. A ativação de Raf leva à fosforilação de MEK, que subsequentemente ativa ERK, influenciando a divisão celular, diferenciação e sobrevivência. Mutações em Raf, particularmente em B-Raf, estão associadas a vários tipos de câncer, tornando Raf um alvo crucial na terapia contra o câncer. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de Raf para apoiar sua pesquisa em oncologia, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 82 produtos de "Raf"
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LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Cor e Forma:SolidPeso molecular:502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Cor e Forma:SolidPeso molecular:388.47Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 98.83%Cor e Forma:SolidPeso molecular:462.89LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Cor e Forma:SolidPeso molecular:528.49Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Fórmula:C21H16ClF3N4O3Pureza:98% - 99.89%Cor e Forma:SolidPeso molecular:464.82Sorafenib tosylate
CAS:Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).Fórmula:C21H16ClF3N4O3·C7H8O3SPureza:99.24% - 99.94%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:637.03Pepinh-TRIF TFA
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interactionFórmula:C180H279F3N58O40S2Pureza:98%Cor e Forma:SolidPeso molecular:4014.09741Regorafénib N-oxyde (M2)
CAS:<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Fórmula:C21H15ClF4N4O4Pureza:98.03% - 98.26%Cor e Forma:SolidPeso molecular:498.81B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Fórmula:C20H17F2N5O4SPureza:98.86%Cor e Forma:SolidPeso molecular:461.44Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFórmula:C63H68F5N7O9SPureza:98%Cor e Forma:SolidPeso molecular:1194.31R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Cor e Forma:SolidPeso molecular:2309.69Cyclorasin 9A5
CAS:<p>Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibition</p>Fórmula:C75H108FN25O13Pureza:98%Cor e Forma:SolidPeso molecular:1586.82Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Fórmula:C75H108FN25O13·xC2HF3O2Cor e Forma:SolidPeso molecular:1586.82 (free base)SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Cor e Forma:SolidPeso molecular:541.61MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Cor e Forma:Odour SolidRef: TM-L1400
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarVUBI1-octanoic acid
VUBI1-octanoic acid is a conjugate of both the SOS1 ligand and linker, and it is applied in the synthesis of (4S)-PROTAC SOS1 degrader-1.Cor e Forma:Odour SolidKG5
CAS:<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Fórmula:C20H16F3N7OSPureza:98.32%Cor e Forma:SolidPeso molecular:459.45SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Fórmula:C22H24F3N5OPureza:99.4%Cor e Forma:SolidPeso molecular:431.45Ref: TM-T60029
1mg75,00€5mg169,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€1mL*10mM (DMSO)180,00€Anti-Phospho-RAF1 (Ser259) Antibody (5X237)
<p>Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.</p>Cor e Forma:Odour LiquidAnti-Phospho-RAF1 (Ser621) Antibody (2K681)
Anti-Phospho-RAF1 (Ser621) Antibody (2K681) is an antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Antibody (2K681) can be used in ELISA, WB, IF.Cor e Forma:Odour LiquidAnti-Phospho-RAF1 (Ser43) Antibody (8R108)
Anti-Phospho-RAF1 (Ser43) Antibody (8R108) is an antibody targeting Phospho-RAF1 (Ser43). Anti-Phospho-RAF1 (Ser43) Antibody (8R108) can be used in ELISA, IF.Cor e Forma:Odour LiquidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Fórmula:C27H28ClF4N5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:565.99GW 5074
CAS:GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.Fórmula:C15H8Br2INO2Pureza:99.32%Cor e Forma:SolidPeso molecular:520.94Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Fórmula:C23H20F3N5O2S2Pureza:99.62% - >99.99%Cor e Forma:SolidPeso molecular:519.56PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Fórmula:C25H21F3N6O3SPureza:98.75% - >99.99%Cor e Forma:SolidPeso molecular:542.53Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Cor e Forma:SolidPeso molecular:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€1mL*10mM (DMSO)112,00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Cor e Forma:SolidPeso molecular:419.31Agerafenib
CAS:Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Fórmula:C24H22F3N5O5Pureza:95.78% - 99.23%Cor e Forma:SolidPeso molecular:517.46Ref: TM-T2070
1mg42,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg560,00€200mg800,00€1mL*10mM (DMSO)96,00€Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Cor e Forma:SolidPeso molecular:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€1mL*10mM (DMSO)243,00€AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Fórmula:C27H25N5O2Pureza:99.82%Cor e Forma:SolidPeso molecular:451.52TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Cor e Forma:SolidPeso molecular:554.52RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Fórmula:C24H16F6N6OPureza:99.56%Cor e Forma:SolidPeso molecular:518.41Ref: TM-T6296
1mg44,00€2mg59,00€5mg93,00€10mg140,00€25mg253,00€50mg413,00€100mg605,00€1mL*10mM (DMSO)94,00€AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Fórmula:C22H19F4N7OPureza:99.49% - 99.75%Cor e Forma:SolidPeso molecular:473.43Ref: TM-T4301
1mg47,00€5mg92,00€10mg145,00€25mg283,00€50mg464,00€100mg680,00€500mg1.406,00€1mL*10mM (DMSO)96,00€Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Fórmula:C15H8Br2ClNO2Pureza:98.53%Cor e Forma:SolidPeso molecular:429.49Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Cor e Forma:SolidPeso molecular:540.01B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Fórmula:C17H14BrF2N3O3SPureza:99.947%Cor e Forma:SolidPeso molecular:458.28BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:97.16%Cor e Forma:SolidPeso molecular:448.58Ref: TM-T5418
1mg52,00€5mg111,00€10mg187,00€25mg339,00€50mg510,00€100mg748,00€200mg1.035,00€1mL*10mM (DMSO)123,00€RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Cor e Forma:SolidPeso molecular:542.55Ref: TM-T3711
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg259,00€50mg424,00€100mg625,00€500mg1.311,00€1mL*10mM (DMSO)94,00€BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Fórmula:C28H33F2N7O2SPureza:97.33% - 99.07%Cor e Forma:SolidPeso molecular:569.67K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.78Ref: TM-T6556
1mg35,00€5mg82,00€10mg114,00€25mg226,00€50mg329,00€100mg449,00€200mg630,00€1mL*10mM (DMSO)114,00€SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Cor e Forma:SolidPeso molecular:453.54Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Fórmula:C23H18ClF2N3O3SPureza:98.53% - 99.36%Cor e Forma:SolidPeso molecular:489.92Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFórmula:C21H17ClF4N4O4Pureza:99.69%Cor e Forma:SolidPeso molecular:500.83Ref: TM-T1792L
5mg35,00€10mg48,00€25mg69,00€50mg88,00€100mg140,00€200mg207,00€500mg348,00€1mL*10mM (DMSO)58,00€ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Fórmula:C23H23N3O3Pureza:97.24% - 97.51%Cor e Forma:SolidPeso molecular:389.45L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Fórmula:C20H14ClN3OPureza:≥95%Cor e Forma:SolidPeso molecular:347.8PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Cor e Forma:SolidPeso molecular:413.83CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Fórmula:C27H24FN7O3Pureza:98.93% - 99.65%Cor e Forma:SolidPeso molecular:513.52Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Fórmula:C23H16ClFN6OSPureza:98% - 99.65%Cor e Forma:SolidPeso molecular:478.93I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Cor e Forma:SolidPeso molecular:482.92B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Cor e Forma:SolidPeso molecular:515.53Ref: TM-T1845
1mg92,00€2mg119,00€5mg187,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€1mL*10mM (DMSO)221,00€SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:359.41Vemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Fórmula:C23H18ClF2N3O3SPureza:98% - 99.65%Cor e Forma:SolidPeso molecular:489.92LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Fórmula:C23H29FN6OPureza:96.96% - ≥95%Cor e Forma:SolidPeso molecular:424.51PROTAC BRAF-V600E degrader-1
CAS:PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.Fórmula:C48H54F2N10O10SPureza:99.43%Cor e Forma:SolidPeso molecular:1001.07K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.34Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Cor e Forma:SolidPeso molecular:615.67Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Fórmula:C31H37N5O3Pureza:97.14% - 98.80%Cor e Forma:SolidPeso molecular:527.66Ref: TM-T6277
1g532,00€5mg34,00€10mg52,00€25mg74,00€50mg96,00€100mg120,00€200mg213,00€500mg359,00€1mL*10mM (DMSO)42,00€TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Fórmula:C17H12Cl2F3N7O2SPureza:99.25% - 99.77%Cor e Forma:SolidPeso molecular:506.29Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Fórmula:C21H16Cl2F4N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:519.28AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Fórmula:C27H25N5O2Pureza:99.50%Cor e Forma:SolidPeso molecular:451.52Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8HClPureza:98.19% - 99.54%Cor e Forma:SolidPeso molecular:551.86Ref: TM-T4167
1mg49,00€2mg64,00€5mg103,00€10mg180,00€25mg300,00€50mg445,00€100mg652,00€500mg1.378,00€1mL*10mM (DMSO)188,00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8Pureza:99.91%Cor e Forma:SolidPeso molecular:478.94TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.58%Cor e Forma:SolidPeso molecular:531.51Ref: TM-T9693
1mg48,00€5mg97,00€10mg156,00€25mg271,00€50mg408,00€100mg567,00€200mg748,00€1mL*10mM (DMSO)113,00€PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.53BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.47Ref: TM-T10599
1mg47,00€5mg93,00€10mg144,00€25mg250,00€50mg393,00€100mg560,00€200mg812,00€1mL*10mM (DMSO)104,00€MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Fórmula:C33H36N2O3Pureza:97.23%Cor e Forma:OilPeso molecular:508.65Ref: TM-T24437
1mg37,00€5mg97,00€10mg169,00€25mg291,00€50mg423,00€100mg562,00€500mg1.121,00€1mL*10mM (DMSO)108,00€B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Cor e Forma:SoildPeso molecular:439.89GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Fórmula:C19H18N4O2Pureza:99.62%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T6320
1mg38,00€2mg49,00€5mg79,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€200mg807,00€1mL*10mM (DMSO)87,00€GSK2008607
CAS:<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Fórmula:C31H28F3N7O3S2Pureza:99.36%Cor e Forma:SolidPeso molecular:667.72Ref: TM-T27454
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Fórmula:C28H27F3N6O2Pureza:98.32%Cor e Forma:SolidPeso molecular:536.548B-Raf IN 15
CAS:<p>B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.</p>Fórmula:C19H15N3OSPureza:98%Cor e Forma:SolidPeso molecular:333.41Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Cor e Forma:SolidPeso molecular:430.46Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFórmula:C25H17F3N4O3Pureza:97.99% - 98%Cor e Forma:SolidPeso molecular:478.42Ref: TM-T22272
1mg35,00€5mg69,00€10mg97,00€25mg190,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)89,00€Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Fórmula:C22H21F3N4O4SPureza:99.98%Cor e Forma:SolidPeso molecular:494.49Ref: TM-T63333
1mg95,00€5mg202,00€10mg298,00€25mg630,00€50mg948,00€100mg1.644,00€500mg3.307,00€1mL*10mM (DMSO)224,00€B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Fórmula:C20H19N5O3SPureza:99.31% - 99.78%Cor e Forma:SolidPeso molecular:409.46HG6-64-1
CAS:HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Fórmula:C32H34F3N5O2Pureza:99.89%Cor e Forma:SolidPeso molecular:577.64Ref: TM-T15480
1mg72,00€5mg156,00€10mg227,00€25mg393,00€50mg550,00€100mg747,00€1mL*10mM (DMSO)188,00€Brimarafenib
CAS:Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Fórmula:C24H17F3N4O4Pureza:98.32%Cor e Forma:SolidPeso molecular:482.41pan-Raf/RTK inhibitor 1
CAS:Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.Fórmula:C29H28F3N7O3Cor e Forma:SolidPeso molecular:579.573Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Fórmula:C26H27BrF3N5O2Pureza:99.73%Cor e Forma:SolidPeso molecular:578.42Ref: TM-T11224
1mg92,00€5mg178,00€10mg335,00€25mg568,00€50mg808,00€100mg1.093,00€1mL*10mM (DMSO)235,00€SKLB646
CAS:<p>SKLB646 is an orally active multitarget kinase inhibitor that exhibits potent suppression of several kinases. It demonstrates significant inhibitory effects on SRC and VEGFR2, with IC50 values of 0.002 μmol/L and 0.012 μmol/L, respectively. Additionally, SKLB646 shows notable inhibition of B-Raf and C-Raf, with IC50 values of 0.022 μmol/L and 0.019 μmol/L, respectively. The compound inhibits the activation of the SRC signaling pathway and blocks the MAPK signaling pathway by inhibiting Raf kinases. Furthermore, SKLB646 inhibits the proliferation, migration, and invasion of human umbilical vein endothelial cells (HUVEC), thereby suppressing tumor-induced angiogenesis. SKLB646 also displays significant anti-proliferative and anti-survival effects on triple-negative breast cancer (TNBC) cell lines.</p>Fórmula:C28H26F3N7OCor e Forma:SolidPeso molecular:533.55Ref: TM-T200104
Produto descontinuadoIHMT-RAF-128
CAS:<p>IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor models without causing significant toxicity.</p>Fórmula:C27H24F3N5O2Cor e Forma:SolidPeso molecular:507.51
