Raf
As quinases Raf são componentes-chave da via de sinalização MAPK/ERK, desempenhando um papel crítico na transmissão de sinais da membrana celular para o núcleo. A ativação de Raf leva à fosforilação de MEK, que subsequentemente ativa ERK, influenciando a divisão celular, diferenciação e sobrevivência. Mutações em Raf, particularmente em B-Raf, estão associadas a vários tipos de câncer, tornando Raf um alvo crucial na terapia contra o câncer. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de Raf para apoiar sua pesquisa em oncologia, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 86 produtos para "Raf".
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K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Cor e Forma:SolidPeso molecular:513.778SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Cor e Forma:SolidPeso molecular:453.5356Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:482.815Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFórmula:C21H17ClF4N4O4Pureza:99.69%Cor e Forma:SolidPeso molecular:500.83ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Fórmula:C23H23N3O3Pureza:97.24% - 97.51%Cor e Forma:SolidPeso molecular:389.45GW 5074
CAS:GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.Fórmula:C15H8Br2INO2Pureza:99.32%Cor e Forma:Yellow SolidPeso molecular:520.94L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Fórmula:C20H14ClN3OPureza:98.48%Cor e Forma:SolidPeso molecular:347.798PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.96%Cor e Forma:White SolidPeso molecular:413.826CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Fórmula:C27H24FN7O3Pureza:98.93% - 99.65%Cor e Forma:SolidPeso molecular:513.523Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Fórmula:C23H16ClFN6OSPureza:98% - 99.65%Cor e Forma:Yellow SolidPeso molecular:478.929I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Cor e Forma:Yellow SolidPeso molecular:482.92B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Cor e Forma:SolidPeso molecular:515.529Vemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Fórmula:C23H18ClF2N3O3SPureza:98% - 99.94%Cor e Forma:SolidPeso molecular:489.92LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Fórmula:C23H29FN6OPureza:96.96% - ≥95%Cor e Forma:Yellow SolidPeso molecular:424.5144PROTAC BRAF-V600E degrader-1
CAS:PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.Fórmula:C48H54F2N10O10SPureza:99.43%Cor e Forma:SolidPeso molecular:1001.07Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Fórmula:C23H20F3N5O2S2Pureza:99.62% - >99.99%Cor e Forma:SolidPeso molecular:519.562Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Cor e Forma:SolidPeso molecular:615.668KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Fórmula:C110H186N44O27S2Pureza:99.34%Cor e Forma:SolidPeso molecular:2621.06TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Fórmula:C17H12Cl2F3N7O2SPureza:99.60% - 99.77%Cor e Forma:White SolidPeso molecular:506.289Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Fórmula:C21H16Cl2F4N4O3Pureza:99.56%Cor e Forma:SolidPeso molecular:519.276
