Raf
As quinases Raf são componentes-chave da via de sinalização MAPK/ERK, desempenhando um papel crítico na transmissão de sinais da membrana celular para o núcleo. A ativação de Raf leva à fosforilação de MEK, que subsequentemente ativa ERK, influenciando a divisão celular, diferenciação e sobrevivência. Mutações em Raf, particularmente em B-Raf, estão associadas a vários tipos de câncer, tornando Raf um alvo crucial na terapia contra o câncer. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de Raf para apoiar sua pesquisa em oncologia, transdução de sinais e desenvolvimento terapêutico.
Foram encontrados 86 produtos para "Raf".
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AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Fórmula:C27H25N5O2Pureza:99.50%Cor e Forma:SolidPeso molecular:451.52Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Fórmula:C26H21Cl3N8Pureza:98.75% - 99.54%Cor e Forma:SolidPeso molecular:551.858Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8Pureza:99.91%Cor e Forma:SolidPeso molecular:478.936TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Fórmula:C27H23F2N7O3Pureza:99.28% - 99.58%Cor e Forma:Yellow SolidPeso molecular:531.5134PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Fórmula:C24H22F2N6O3SPureza:99.51% - 99.66%Cor e Forma:SolidPeso molecular:512.532Kobe2601
CAS:Kobe2601 is a water-soluble structural analog of Kobe0065. Kobe2601 inhibits Ras-Raf binding.Fórmula:C13H10FN5O4SPureza:99.24%Cor e Forma:SolidPeso molecular:351.31PLX7683
CAS:PLX7683 is a RAF pathway paradox breaker used in MAPK signaling and resistance mutation research.Fórmula:C23H19ClF2N4O3SPureza:97.60%Cor e Forma:SolidPeso molecular:504.94MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Fórmula:C33H36N2O3Pureza:97.23%Cor e Forma:OilPeso molecular:508.6505RAF-IN-1
CAS:RAF-IN-1 inhibits cRAF, BRAF and BRAFV600E, with GI50 3.4 and 2.9 nM in mutant cell lines.Fórmula:C26H22F3N3O4Pureza:99.62%Cor e Forma:White SolidPeso molecular:497.47GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Fórmula:C19H18N4O2Pureza:99.62%Cor e Forma:SolidPeso molecular:334.37BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Cor e Forma:SolidPeso molecular:456.465K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3 covalently binds G12C mutant cysteine, locking K-Ras in an inactive GDP-bound state and blocking MAPK/ERK signaling.Fórmula:C21H19Cl3N2O3Cor e Forma:SolidPeso molecular:453.746B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Cor e Forma:SolidPeso molecular:439.89SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Fórmula:C28H27F3N6O2Pureza:98.32%Cor e Forma:SolidPeso molecular:536.548GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Fórmula:C31H28F3N7O3S2Pureza:99.99%Cor e Forma:SolidPeso molecular:667.724B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Fórmula:C19H15N3OSPureza:98%Cor e Forma:SolidPeso molecular:333.41B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Fórmula:C20H19N5O3SPureza:99.78% - 99.85%Cor e Forma:SolidPeso molecular:409.46Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFórmula:C25H17F3N4O3Pureza:97.99% - 98%Cor e Forma:SolidPeso molecular:478.4227Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Cor e Forma:SolidPeso molecular:430.46Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Fórmula:C22H21F3N4O4SPureza:99.98%Cor e Forma:SolidPeso molecular:494.487
