CFTR
CFTR é uma proteína de canal de cloreto que regula o transporte de íons cloreto e bicarbonato através das membranas das células epiteliais, desempenhando um papel crucial na manutenção do equilíbrio de fluidos nos tecidos. As mutações no gene CFTR levam à fibrose cística, uma desordem genética caracterizada pela produção de muco espesso que pode obstruir as vias aéreas e levar a graves problemas respiratórios e digestivos. Na CymitQuimica, oferecemos uma seleção de moduladores de CFTR para apoiar sua pesquisa em fibrose cística, transporte de íons e distúrbios genéticos.
Foram encontrados 66 produtos de "CFTR"
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CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Fórmula:C27H23FN4O4Pureza:99.66%Cor e Forma:SolidPeso molecular:486.49Ref: TM-T5312
2mg37,00€5mg55,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg147,00€50mg215,00€100mg318,00€200mg444,00€GlyH-101
CAS:GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Fórmula:C19H15Br2N3O3Pureza:98.71% - 98.78%Cor e Forma:SolidPeso molecular:493.15Ref: TM-T2451
1mg34,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg103,00€25mg210,00€50mg354,00€100mg530,00€200mg755,00€Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Fórmula:C24H28N2O3Pureza:99% - 99.98%Cor e Forma:SolidPeso molecular:392.49Ref: TM-T2588
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg120,00€25mg195,00€50mg288,00€100mg416,00€200mg600,00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Fórmula:C26H27F3N2O6Pureza:98.84% - >99.99%Cor e Forma:SolidPeso molecular:520.5Ref: TM-T2263
1mg38,00€2mg50,00€5mg78,00€1mL*10mM (DMSO)94,00€10mg116,00€25mg200,00€50mg324,00€100mg477,00€GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Fórmula:C16H20N4O3SPureza:99.64% - 99.91%Cor e Forma:SolidPeso molecular:348.42Glibenclamide potassium
CAS:Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.Fórmula:C23H27ClKN3O5SCor e Forma:SolidPeso molecular:532.09IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Fórmula:C22H15Br2N3O4Pureza:98.92% - ≥95%Cor e Forma:SolidPeso molecular:545.18KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFórmula:C19H17Cl2N3O2SPureza:98.86%Cor e Forma:SolidPeso molecular:422.33Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Fórmula:C12H13F6N3O3Pureza:99.76%Cor e Forma:SolidPeso molecular:361.24Ref: TM-T9499
1mg152,00€1mL*10mM (DMSO)248,00€5mg313,00€10mg469,00€25mg750,00€50mg1.054,00€100mg1.494,00€200mg2.025,00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Fórmula:C15H9FN2O3Pureza:99.16% - 99.84%Cor e Forma:SolidPeso molecular:284.24Ref: TM-T1805
5mg35,00€1mL*10mM (DMSO)46,00€10mg54,00€25mg88,00€50mg117,00€100mg178,00€200mg213,00€500mg359,00€SRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Fórmula:C22H19N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:357.41Ref: TM-T2S1837
1mg49,00€1mL*10mM (DMSO)73,00€5mg89,00€10mg154,00€25mg250,00€50mg371,00€100mg552,00€200mg785,00€(R)-Olacaftor
CAS:(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.Fórmula:C29H34FN3O4SCor e Forma:SolidPeso molecular:539.66SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Fórmula:C24H23N3O2Pureza:98.73%Cor e Forma:SolidPeso molecular:385.46Ivacaftor-D9
CAS:CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.Fórmula:C24H19D9N2O3Cor e Forma:SolidPeso molecular:401.55AF-2785
CAS:In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.Fórmula:C17H12Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:347.2CFTR corrector 9
CAS:CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Fórmula:C16H14N2O4Pureza:99.75%Cor e Forma:SolidPeso molecular:298.29Ref: TM-T60653
2mg39,00€1mL*10mM (DMSO)58,00€5mg60,00€10mg96,00€25mg170,00€50mg253,00€100mg363,00€200mg510,00€Corrector C4
CAS:Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants andFórmula:C21H17ClN4O2S2Pureza:99.98%Cor e Forma:SolidPeso molecular:456.97Galicaftor
CAS:ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).Fórmula:C28H21F4NO7Pureza:98.84%Cor e Forma:SolidPeso molecular:559.46Ref: TM-T22252
1mgA consultar10mgA consultar5mg192,00€1mL*10mM (DMSO)236,00€25mg625,00€50mg982,00€100mg1.639,00€Posenacaftor sodium
CAS:Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.Fórmula:C27H27NNaO5Cor e Forma:SolidPeso molecular:468.505
