Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 277 produtos de "Canal de Potássio"
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4-Aminopyridine
CAS:<p>4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.</p>Fórmula:C5H6N2Pureza:91.61%Cor e Forma:SolidPeso molecular:94.11Ropivacaine hydrochloride
CAS:<p>Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity</p>Fórmula:C17H26N2O·HClPureza:99.85% - 99.95%Cor e Forma:SolidPeso molecular:310.86VU6036720
<p>VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit</p>Fórmula:C20H22ClFN4O2SPureza:98.1%Cor e Forma:SoildPeso molecular:436.93Oxybutynin
CAS:<p>Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.</p>Fórmula:C22H31NO3Pureza:97.81% - 99.57%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:357.49Miconazole
CAS:<p>Miconazole (R18134) is an imidazole antifungal agent that is used topically and by intravenous infusion.</p>Fórmula:C18H14Cl4N2OPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:416.13Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Fórmula:C22H22FN3O3Pureza:99.19% - 99.73%Cor e Forma:SolidPeso molecular:395.43Halothane
CAS:<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>Fórmula:C2HBrClF3Pureza:98.50% - >99.99%Cor e Forma:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustiblePeso molecular:197.38Linoleoyl glycine
CAS:<p>Linoleoyl glycine activates hKCNQ1/hKCNE1 channels, has analgesic properties, and is found in skin, spinal cord, and brain.</p>Fórmula:C20H35NO3Pureza:98.96%Cor e Forma:SolidPeso molecular:337.5Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Cor e Forma:SolidPeso molecular:494.00Clofilium tosylate
CAS:<p>Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.</p>Fórmula:C28H44ClNO3SPureza:99.68%Cor e Forma:SolidPeso molecular:510.17Quinine
CAS:<p>Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria.</p>Fórmula:C20H24N2O2Pureza:99.93% - 99.97%Cor e Forma:White Solid PowderPeso molecular:324.42Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Fórmula:C12H21NO8SPureza:99.79% - 99.92%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:339.36Proflavine Hemisulfate
CAS:<p>Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.</p>Fórmula:C13H12N3O2S0Pureza:99.55%Cor e Forma:Orange To Red PowderPeso molecular:258.29Flindokalner
CAS:<p>Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.</p>Fórmula:C16H10ClF4NO2Pureza:99.96%Cor e Forma:SolidPeso molecular:359.7NS19504
CAS:<p>NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM.</p>Fórmula:C10H9BrN2SPureza:99.87%Cor e Forma:SolidPeso molecular:269.16Nicorandil
CAS:<p>Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.</p>Fórmula:C8H9N3O4Pureza:98.14% - >99.99%Cor e Forma:White Or Off-White PowderPeso molecular:211.17Rosuvastatin calcium
CAS:<p>Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic</p>Fórmula:(C22H27FN3O6S)CaPureza:98.21% - 99.68%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:1001.14NS3623
CAS:<p>NS3623 is an activator of human ether-a-go-go-related gene potassium channels.</p>Fórmula:C15H10BrF3N6OPureza:97.06%Cor e Forma:SolidPeso molecular:427.18DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Fórmula:C22H28Cl2O4Pureza:99.79% - 99.87%Cor e Forma:SolidPeso molecular:427.36Tannic acid
CAS:<p>Tannic acid (Gallotannic acid) is a novel hERG channel blocker.</p>Fórmula:C76H52O46Pureza:AR - ARCor e Forma:Light Yellow To Light Brown Solid Solid Particulate/PowderPeso molecular:1701.2Gliclazide
CAS:<p>Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the</p>Fórmula:C15H21N3O3SPureza:99.58%Cor e Forma:SolidPeso molecular:323.41Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Fórmula:C32H41NO2Pureza:98.76% - 99.75%Cor e Forma:SolidPeso molecular:471.67Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Fórmula:C17H16F6N2OPureza:99.89%Cor e Forma:SolidPeso molecular:378.31ICA-27243
CAS:<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Fórmula:C12H7ClF2N2OPureza:99.54%Cor e Forma:SolidPeso molecular:268.65Amiodarone hydrochloride
CAS:<p>Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.</p>Fórmula:C25H29I2NO3·HClPureza:99.82% - ≥95%Cor e Forma:White To Cream Crystalline PowderPeso molecular:681.78Diazoxide
CAS:<p>Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.</p>Fórmula:C8H7ClN2O2SPureza:99% - 99.83%Cor e Forma:SolidPeso molecular:230.67Oxybutynin chloride
CAS:<p>Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties.</p>Fórmula:C22H32ClNO3Pureza:99.27% - >99.99%Cor e Forma:White PowderPeso molecular:393.96DCEBIO
CAS:<p>DCEBIO, a 1-EBIO derivative, enhances Cl- secretion via hIK1 K+ channel and apical conductance in T84 cells.</p>Fórmula:C9H8Cl2N2OPureza:99.89%Cor e Forma:SolidPeso molecular:231.08Ropivacaine
CAS:Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.Fórmula:C17H26N2OPureza:97.75% - >99.99%Cor e Forma:SolidPeso molecular:274.40BMS-191095
CAS:<p>BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.</p>Fórmula:C22H21ClN4O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:408.88Repaglinide
CAS:<p>Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.</p>Fórmula:C27H36N2O4Pureza:99.73% - >99.99%Cor e Forma:White To Off-White SolidPeso molecular:452.59N-Acetylprocainamide
CAS:<p>N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic</p>Fórmula:C15H23N3O2Pureza:99.65% - 99.74%Cor e Forma:SolidPeso molecular:277.36Cloperastine hydrochloride
CAS:<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>Fórmula:C20H25Cl2NOPureza:97.74% - 99.42%Cor e Forma:SolidPeso molecular:366.33VU591
CAS:VU591 is a selective extra-renal potassium channel inhibitor with an IC₅₀ of 0.24 μM.Fórmula:C16H12N6O5Pureza:99.29% - 99.53%Cor e Forma:SolidPeso molecular:368.3BMS-394136
CAS:<p>BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.</p>Fórmula:C24H21Cl2FN4OPureza:98.19% - 98.67%Cor e Forma:SolidPeso molecular:471.35Dequalinium chloride
CAS:<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>Fórmula:C30H40Cl2N4Pureza:99.79% - 99.9%Cor e Forma:SolidPeso molecular:527.59AZD 7009
CAS:<p>AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.</p>Fórmula:C23H34N4O5Pureza:98.42% - 98.51%Cor e Forma:SoildPeso molecular:446.54Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Fórmula:C21H27NO3Pureza:99.02%Cor e Forma:SolidPeso molecular:341.44Ifenprodil Tartrate
CAS:<p>Ifenprodil is a selective NMDA receptor (glutamate) antagonist.</p>Fórmula:C21H27NO2C4H6O6Pureza:99.02% - 99.55%Cor e Forma:SolidPeso molecular:400.49Minoxidil
CAS:<p>Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.</p>Fórmula:C9H15N5OPureza:99.885% - >99.99%Cor e Forma:Crystals From Methanol-Acetonitrile SolidPeso molecular:209.251-EBIO
CAS:<p>1-EBIO (1-EBIO) is a calium channel agonist.</p>Fórmula:C9H10N2OPureza:98.75%Cor e Forma:SolidPeso molecular:162.19Astemizole
CAS:<p>Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.</p>Fórmula:C28H31FN4OPureza:98.24% - 99.67%Cor e Forma:White Crystals SolidPeso molecular:458.57Linopirdine
CAS:<p>Linopirdine (DuP 996) is a TRPV1 agonist.</p>Fórmula:C26H21N3OPureza:99.45% - 99.78%Cor e Forma:SolidPeso molecular:391.46Minocycline hydrochloride
CAS:<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Fórmula:C23H28ClN3O7Pureza:99.28% - >99.99%Cor e Forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94VU591 hydrochloride
CAS:<p>VU591 hydrochloride is a selective Kir1.1 (ROMK) blocker with IC50 of 0.24 μM, not affecting Kir7.1, Kir2.1, Kir2.3, or Kir4.1, similar to VU 590.</p>Fórmula:C16H13ClN6O5Pureza:98.93% - 99.22%Cor e Forma:SolidPeso molecular:404.76Tipepidine hydrochloride
CAS:Tipepidine hydrochloride: reversible DA D2 receptor inhibitor, IC50 7.0 μM, with antidepressant effects.Fórmula:C15H18ClNS2Pureza:99.97%Cor e Forma:SolidPeso molecular:311.89NS8593 hydrochloride
CAS:<p>NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .</p>Fórmula:C17H18ClN3Pureza:99.77%Cor e Forma:SolidPeso molecular:299.8Butamben
CAS:Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.Fórmula:C11H15NO2Pureza:99.43%Cor e Forma:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Peso molecular:193.24Bupivacaine hydrochloride
CAS:Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.Fórmula:C18H28N2O·HClPureza:99.89% - 99.9%Cor e Forma:SolidPeso molecular:324.89Quinidine hydrochloride monohydrate
CAS:<p>Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.</p>Fórmula:C20H27ClN2O3Pureza:94.4% - 99.68%Cor e Forma:SolidPeso molecular:378.89Glipizide
CAS:<p>Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.</p>Fórmula:C21H27N5O4SPureza:99.67% - 99.75%Cor e Forma:SolidPeso molecular:445.54Phenformin hydrochloride
CAS:<p>Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.</p>Fórmula:C10H16ClN5Pureza:97.11% - 99.80%Cor e Forma:Lactic AcidosisPeso molecular:241.72Disopyramide
CAS:<p>Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.</p>Fórmula:C21H29N3OPureza:99.62%Cor e Forma:SolidPeso molecular:339.47NS13001
CAS:<p>NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).</p>Fórmula:C17H16ClN7Pureza:99.55%Cor e Forma:SolidPeso molecular:353.81Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Fórmula:C17H17ClF6N2OPureza:99% - 99.99%Cor e Forma:Off-White To Yellow SolidPeso molecular:414.77Brompheniramine maleate
CAS:<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>Fórmula:C16H19BrN2·C4H4O4Pureza:99.80%Cor e Forma:Crystal PowderPeso molecular:435.31Dronedarone hydrochloride
CAS:<p>Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.</p>Fórmula:C31H44N2O5S·HClPureza:99.61%Cor e Forma:SolidPeso molecular:593.22Hydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Fórmula:C7H8ClN3O4S2Pureza:99.43% - 99.50%Cor e Forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecular:297.74Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Fórmula:C14H10F3NO2Pureza:98.68%Cor e Forma:White To Light Yellow Crystalline PowderPeso molecular:281.23NS5806
CAS:<p>NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).</p>Fórmula:C16H8Br2F6N6OPureza:97.95%Cor e Forma:SolidPeso molecular:574.07VU0134992 hydrochloride
CAS:VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).Fórmula:C20H32BrClN2O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:447.84Tolbutamide
CAS:<p>Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.</p>Fórmula:C12H18N2O3SPureza:99.80% - 99.93%Cor e Forma:White Crystalline PowderPeso molecular:270.35IK1 inhibitor PA-6
CAS:<p>IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse</p>Fórmula:C31H32N4O2Pureza:98.9%Cor e Forma:SolidPeso molecular:492.61ML418
CAS:<p>ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.</p>Fórmula:C19H24ClN3O3Pureza:99.3%Cor e Forma:SolidPeso molecular:377.87Eleclazine hydrochloride
CAS:<p>Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).</p>Fórmula:C21H17ClF3N3O3Pureza:99.86%Cor e Forma:SolidPeso molecular:451.83Doxapram hydrochloride hydrate
CAS:<p>Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.</p>Fórmula:C24H33ClN2O3C24H30N2O2·ClH·H2OPureza:99.64% - >99.99%Cor e Forma:SolidPeso molecular:432.99Hydroxyhexamide
CAS:<p>Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.</p>Fórmula:C15H22N2O4SPureza:98.91%Cor e Forma:SolidPeso molecular:326.41Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C179H274N50O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4230ADWX 1 TFA
<p>ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.</p>Fórmula:C169H281N57O46S7·xC2HF3O2Cor e Forma:SolidPeso molecular:4071.85 (free base)CHET3
CAS:<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Fórmula:C21H21N5O3SPureza:99.64% - >99.99%Cor e Forma:SoildPeso molecular:423.49Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Fórmula:C106H179N33O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2428.03Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Cor e Forma:Odour SolidPotassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Cor e Forma:Odour SolidCesium chloride
CAS:<p>Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.</p>Fórmula:ClCsPureza:98%Cor e Forma:White Solid CrystallinePeso molecular:168.36Myomodulin
CAS:<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Fórmula:C36H67N11O8S2Pureza:98%Cor e Forma:SolidPeso molecular:846.12Aekatperone
<p>Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).</p>Fórmula:C20H25N5O2SCor e Forma:SolidPeso molecular:399.51Phe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Fórmula:C33H44F6N8O8SPureza:98%Cor e Forma:SolidPeso molecular:826.81Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Pureza:96.97%Cor e Forma:SolidDalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Cor e Forma:SolidPeso molecular:4317.53 (Free base)Pinacidil monohydrate
CAS:<p>Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.</p>Fórmula:C13H21N5OPureza:99.94% - 99.98%Cor e Forma:PowderPeso molecular:263.34Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Fórmula:C29H42N8O4SPureza:98%Cor e Forma:SolidPeso molecular:598.76BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Fórmula:C174H261N51O52S6Pureza:98%Cor e Forma:SolidPeso molecular:4091.65Dendrotoxin K
CAS:<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Fórmula:C294H462N84O75S6Cor e Forma:SolidPeso molecular:6559.66Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Fórmula:C17H19F2N3O2Cor e Forma:SolidPeso molecular:335.349Guangxitoxin 1E
CAS:<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Fórmula:C178H248N44O45S7Pureza:98%Cor e Forma:SolidPeso molecular:3948.61ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Fórmula:C166H268N54O48S7Pureza:98%Cor e Forma:SolidPeso molecular:4012.7Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Fórmula:C141H236N46O39S6Pureza:98%Cor e Forma:SolidPeso molecular:3392.06GsAF-II
<p>GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium</p>Fórmula:C176H261N47O45S7Pureza:98%Cor e Forma:SolidPeso molecular:3979.7MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Fórmula:C22H21N7O3SCor e Forma:SolidPeso molecular:463.512Heteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Fórmula:C168H238N46O51S6Pureza:98%Cor e Forma:SolidPeso molecular:3910.35Guanfu base A
CAS:<p>Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.</p>Fórmula:C24H31NO6Pureza:99.71% - 99.85%Cor e Forma:SolidPeso molecular:429.5AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Fórmula:C158H262N50O48S6Pureza:98%Cor e Forma:SolidPeso molecular:3822.47GsAF-I
<p>GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28</p>Fórmula:C160H244N46O42S7Pureza:98%Cor e Forma:SolidPeso molecular:3708.39HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Fórmula:C337H503N103O97S6Peso molecular:7736.59176Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Fórmula:C19H23F2N3O2Cor e Forma:SolidPeso molecular:363.4BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Cor e Forma:SolidPeso molecular:496.418RU-TRAAK-2
CAS:<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Fórmula:C19H17N3OSPureza:99.81%Cor e Forma:SolidPeso molecular:335.42Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Fórmula:C169H278N54O48S8Pureza:98%Cor e Forma:SolidPeso molecular:4090.87Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2027.34ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Fórmula:C169H281N57O46S7Pureza:98%Cor e Forma:SolidPeso molecular:4071.86
